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Castelo-Branco C.,Clinic Institute of Gynecology | Castelo-Branco C.,University of Barcelona | Castelo-Branco C.,Institute dinvestigacions Biomediques August Pi i Sunyer IDIBAPS | Parera N.,Institute Universitari Dexeus | And 3 more authors.
Gynecological Endocrinology | Year: 2014

Objective: To assess alcohol abuse as a predictor of risky sexual behavior among adolescents and young adult women, a high-risk population for unintended pregnancies. Subjects: Totally 3163 adolescent and young adult women, 18-29 years, were assessed on sociodemographics, alcohol and drug use and risky sexual behaviors. Interventions: Participants answered a structured questionnaire on their leisure habits, drug and alcohol consumption, contraception and sexual behaviors. Results: Most of the young adult women perceive that sexuality is an important part of their life but not a main concern (77.6%) and that alcohol removes the barriers to have sex (62.3%). Additionally, 77.0% claimed that contraception had "a lot" (53.4%) and "quite" (23.6%) influence on the quality of their sexuality. However, up to a 38.4% of the interviewed women had had sex without using any contraception and 29.6% of them acknowledged that had taken alcohol and of these, 40.7% said that alcohol was responsible for not using contraception. Alcohol abuse predicted an increase in risky sexual behaviours (4.45 CI: 2.01-9.75, p<0.0001). The effect of alcohol was independent of age. Conclusions: These findings suggest that contraception-related behavioural interventions for young adult women should discuss the link between alcohol and sexual risk behavior. © 2014 Informa UK Ltd. All rights reserved: reproduction in whole or part not permitted.

Diaz I.,University of Oviedo | Montanes E.,University of Oviedo | Combarro E.F.,University of Oviedo | Espuna-Pons M.,Clinic Institute of Gynecology
International Journal of Computer Mathematics | Year: 2011

This work develops a decision-supported system based on machine learning and scoring measures to discover the kind of female urinary incontinence (FUI) of a given patient. This system has two main branches. Each patient is characterized by a set of features (age, weight, number of childbirths, etc.). The first task consists of selecting the feature set which best defines each FUI class. This feature set is computed according to a some scoring measures. The patients characterized by the optimum feature set are then classified according to a Support Vector Machine classifier. The results are evaluated in terms of macroaccuracy, i.e. the mean of the percentages of correctly classified stress, mixed and sensory urge incontinence. © 2011 Taylor & Francis.

Amaral A.,Human Genetics Research Group | Amaral A.,University of Coimbra | Castillo J.,Human Genetics Research Group | Estanyol J.M.,University of Barcelona | And 3 more authors.
Molecular and Cellular Proteomics | Year: 2013

Proteomic studies are contributing greatly to our understanding of the sperm cell, and more detailed descriptions are expected to clarify additional cellular and molecular sperm attributes. The aim of this study was to characterize the subcellular proteome of the human sperm tail and, hopefully, identify less concentrated proteins (not found in whole cell proteome studies). Specifically, we were interested in characterizing the sperm metabolic proteome and gaining new insights into the sperm metabolism issue. Sperm were isolated from normozoospermic semen samples and depleted of any contaminating leukocytes. Tail fractions were obtained by means of sonication followed by sucrose-gradient ultracentrifugation, and their purity was confirmed via various techniques. Liquid chromatography and tandem mass spectrometry of isolated sperm tail peptides resulted in the identification of 1049 proteins, more than half of which had not been previously described in human sperm. The categorization of proteins according to their function revealed two main groups: proteins related to metabolism and energy production (26%), and proteins related to sperm tail structure and motility (11%). Interestingly, a great proportion of the metabolic proteome (24%) comprised enzymes involved in lipid metabolism, including enzymes for mitochondrial beta-oxidation. Unexpectedly, we also identified various peroxisomal proteins, some of which are known to be involved in the oxidation of very long chain fatty acids. Analysis of our data using Reactome suggests that both mitochondrial and peroxisomal pathways might indeed be active in sperm, and that the use of fatty acids as fuel might be more preponderant than previously thought. In addition, incubation of sperm with the fatty acid oxidation inhibitor etomoxir resulted in a significant decrease in sperm motility. Contradicting a common concept in the literature, we suggest that the male gamete might have the capacity to obtain energy from endogenous pools, and thus to adapt to putative exogenous fluctuations. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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