São Paulo, Brazil
São Paulo, Brazil

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Felix G.E.S.,Federal University of Bahia | Abe-Sandes K.,Bahia State University | Bonfim T.M.,Federal University of Bahia | Bendicho M.T.,Federal University of Bahia | And 8 more authors.
Revista Brasileira de Hematologia e Hemoterapia | Year: 2010

A complete blood count is very useful in clinical diagnoses when reference ranges are well established for the population. Complete blood counts and allele frequencies of Ancestry Informative Markers (AIMs) were analyzed in Brazilians with the aim of characterizing the hematological values of an admixed population. Positive associations were observed between gender and neutrophils, monocytes, eosinophils, erythrocytes, hemoglobin, hematocrit, MCV, MCHC and platelet counts. No significant differences were found for age, alcohol consumption, educational status, ethnicity, smoking in respect to the complete blood count values. In general, men had higher red blood cell values, while women had higher values for white blood cells and platelets. The study of the population was highly heterogeneous with mean proportions (± SE) of African, European and Amerindian ancestry being 49.0 ± 3.0%, 44.0 ± 9.0% and 7.0 ± 9.0%, respectively. Amerindian ancestry showed limited contribution to the makeup of the population, but estimated ancestral proportions were statistically significant (r = 0.9838; P<0.001). These hematologic values are similar to Afro-Americans, another admixed population.


Camargo C.A.,University of Campinas | da Silva M.E.F.,Institute Ciencias da Saude | da Silva R.A.,University of Campinas | Justo G.Z.,University of Sao Paulo | And 2 more authors.
Biochemical and Biophysical Research Communications | Year: 2011

Quercetin, a flavonoid abundantly present in fruit, vegetables, wine and tea, has revealed several properties such as antioxidant, antiproliferative and anticancer. Cachexia is a poorly understood syndrome present in already compromised cancer patients, decreasing the quality of life and increasing mortality. Many studies have been performed in an attempt to discover an effective treatment for cachexia, but none of the tested therapies has fulfilled expectations. The objective of the present study was to analyze the effect of quercetin in the therapeutic treatment of cachexia and reversion of tumor growth in rats bearing Walker 256 carcinosarcoma (W256). Rats bearing W256 were treated daily with I.P. quercetin injections, at different doses (10, 15, 25 and 35mg/kg). The results show that 10mg/kg quercetin inhibited tumor growth by about 50% (ED 50) when compared with controls (CTR). Moreover, two animals of this group presented complete tumor regression. Matrix metalloproteinase-2 (MMP-2) activity and vascular endothelial growth factor (VEGF) expression decreased in rats bearing W256 treated with 10mg/kg quercetin when compared with CTR. Thus, the inhibition of tumor growth, survival increase, decrease of MMP-2 and VEGF levels and reduction of cachexia in animals treated with quercetin strongly support the anticancer function of this flavonoid. © 2011 Elsevier Inc.


Martins-Junior J.L.,Paulista University | Bernardi M.M.,Paulista University | Bernardi M.M.,Institute Ciencias da Saude | Bondan E.F.,Paulista University
Life Sciences | Year: 2016

Propentofylline (PPF) is a xanthine derivative with pharmacological effects that are distinct from those of classic methylxanthines. It depresses the activation of microglial cells and astrocytes, which is associated with neuronal damage during neural inflammation and hypoxia. Our previous studies showed that PPF improved remyelination following gliotoxic lesions that were induced by ethidium bromide (EB). In the present study, the long-term effects of PPF on open field behavior in rats with EB-induced focal demyelination were examined. The effects of PPF were first evaluated in naive rats that were not subjected to EB lesions. Behavior in the beam walking test was also evaluated during chronic PPF treatment because impairments in motor coordination can interfere with behavior in the open field. The results showed that PPF treatment in unlesioned rats decreased general activity and caused motor impairment in the beam walking test. Gliotoxic EB injections increased general activity in rats that were treated with PPF compared with rats that received saline solution. Motor incoordination was also attenuated in PPF-treated rats. These results indicate that PPF reversed the effects of EB lesions on behavior in the open field and beam walking test. © 2016 Elsevier Inc. All rights reserved.


Fernandes P.M.,Federal University of Pará | da Silva K.C.S.,Federal University of Pará | de Souza R.C.,Federal University of Pará | da Costa A.F.M.,Secretaria Municipal de Saude de Ananindeua | And 2 more authors.
Acta Scientiarum - Health Sciences | Year: 2014

Oral health and healthy eating habits are related to socioeconomic and cultural conditions of the population and imply the biopsychosocial health of the individual. This study investigated the oral health and feeding frequency of children attending a daycare in the municipality of Ananindeua, Pará State, northern Brazil. This was a cross-sectional study, quantitative and qualitative, descriptive, involving the examination of the oral cavity of children and questionnaires to parents, caregivers and those responsible for the daycare. Forty-seven children aged one to six years participated in this study; most were girls (57.5%). The daycare had no specific place for tooth brushing that was performed only once daily, without flossing. It was reported by parents that 48.94% of children have never visited a dentist. On examination of the oral cavity we observed carious lesion (51.10%), dental calculus (42.55%), fluorosis (10.64%) and gingivitis (2.13%). It was found that the children had 3 or more meals and had the habit of consuming cariogenic foods such as soft drinks, candy and/or gum, even not being provided by the daycare. Most of the children had at least one decayed tooth, and the daycare offered a healthy diet, but the children had the habit of eating cariogenic foods.


De Melo M.D.F.C.,Federal University of Pará | De Melo M.D.F.C.,Institute Ciencias da Saude | Dos Santos E.G.N.,Federal University of Pará | Dos Santos E.G.N.,Instituto Oswaldo Cruz | And 3 more authors.
Parasitology Research | Year: 2012

Satanoperca jurupari (Osteichthyes: Cichlidae) is reported for the first time to be parasitized by the nematodes Procamallanus (Spirocamallanus) rarus Travassos, Artigas and Pereira, 1928, Procamallanus (Spirocamallanus) sp., larvae of Raphidascaroides sp. and Anisakidae gen. sp., and by the acanthocephalan Neoechinorhynchus (Neoechinorhynchus) paraguayensis Machado Filho (Rev Bras Biol 19:379-381, 1959). © Springer-Verlag 2011.


Mendes A.P.S.,Institute Ciencias da Saude | Schalcher T.R.,Institute Ciencias da Saude | Barros T.G.,Institute Ciencias da Saude | Almeida E.D.,Institute Ciencias da Saude | And 4 more authors.
Journal of Computational and Theoretical Nanoscience | Year: 2011

Quantum mechanical calculations at the B3LYP theory level, together with the 6-31G* basis set, were employed to obtain the energy, HOMO, LUMO, MEPs, and charge of dapsone is compared with others derivatives. Conformational analysis using density functional calculations show that symmetric conformational isomer has low energy than asymmetric conformational isomer. The symmetry level was observed by molecular charge analysis. Its redox properties by electrons transfer are dependent of amine and sulphone moieties. Our results explain the oxidation mechanism of dapsone by electron transfer. Copyright © 2011 American Scientific Publishers.


Scalercio S.R.R.A.,Institute Ciencias da Saude | Pereira G.A.N.,Institute Ciencias Exatas e Naturais | Correa I.D.M.,Institute Ciencias da Saude | Oliveira D.J.,Centro Universitario Do Para | And 3 more authors.
Journal of Computational and Theoretical Nanoscience | Year: 2011

A theoretical study about the chloroquine was executed using DFT method (B3LYP/6-31G*) to clarify anti-malarial influence of 4-amine-quinoline (AQ) tautomerism. Stability and reactivity were determined by geometric and energetic parameters in gas phase for AQ as simplified model of chloroquine (CQ) and compared with water and chloroform solvents using PCM methods. The results have shown that AQ is more stable than 4-imine-quinoline (IQ) on the gas phase and these relative energy differences of the tautomers were increased by solvent effect influence. Copyright © 2011 American Scientific Publishers.


Silva V.R.S.,Federal University of Triângulo Mineiro | Soardi F.C.,Federal University of Triângulo Mineiro | Soardi F.C.,University of Campinas | Tanaka S.C.S.V.,Federal University of Triângulo Mineiro | And 3 more authors.
Archives of Gynecology and Obstetrics | Year: 2015

Introduction: Pre-eclampsia (PE) is a pregnancy-specific multisystemic syndrome characterized by high blood pressure and presence of protein in the urine. The pathogenesis of pre-eclampsia is poorly understood and many factors such as environment, genetic, and immunology may be involved in PE pathophysiology. Among the genetic factors, there is an association between pre-eclampsia and polymorphisms in some genes of different population samples, as vascular endothelial growth factor and interleukin 1 alpha. The vascular endothelial growth factor gene is highly polymorphic and acts as a regulator in endothelial cell proliferation and vascular permeability. The secretion of interleukin 1 alpha leads to a pro-inflammatory cascade, which leads to high levels of circulating cytokines. This high amount of cytokines corroborates to structural and functional alterations in endothelial cells. The aim of this study was to investigate the vascular endothelial growth factor (VEGF) G-634C and interleukin 1 alpha (IL1A) rs3783550 polymorphism in a specific Brazilian pre-eclampsia group.Material and Methods: The evaluation of the vascular endothelial growth factor polymorphism was performed by PCR–RFLP restriction enzyme BsmFI and the IL1A polymorphism by allele-specific PCR. Molecular investigation was carried out by fragment size analysis on agarose and/or polyacrylamide gels.Results: However, no relation between polymorphism VEGF G-634C and pre-eclampsia was observed, indicating that further investigations with a larger sampling and other polymorphisms are still required. On the other hand, the rs3783550 polymorphism in the interleukin 1 alpha gene is correlated to pre-eclampsia, indicating that women with the allele A have a higher probability of developing the disease.Conclusion: Thus, the interleukin 1 alpha gene could be used as a therapeutic tool for the diagnosis, as well as for monitoring the patients. © 2014, Springer-Verlag Berlin Heidelberg.


The plant Salvia divinorum Epling & Játiva (SDI), of the Lamiaceae family, has been used for centuries by the Mazateca culture and has gained popularity as a recreational drug in the last years. Its active principle, Salvinorin A (SA), is a potentially psychotropic agonist of the kappa opioid receptors. The use of SDI has increased in Europe and North America, although there are no concrete proofs about abuse. The present review discusses current evidence on potential SDI abuse, as well as its increasing recreational use, although it is considered a legalized hallucinogen easily acquired in many countries.


PubMed | Institute Ciencias da Saude, Federal University of Minas Gerais, Faculdades Unidas do Norte. Montes Claros MG Brazil, State University of Montes Claros and University of Campinas
Type: Journal Article | Journal: Ciencia & saude coletiva | Year: 2016

The scope of this study was to evaluate the association between the presence of common mental disorders and the impairment of subjective health conditions among the elderly. It involved a cross-sectional analytical survey conducted among all the elderly residents in the urban area of a Brazilian municipality with low population density. Mental disorders were evaluated using the short version of the Goldberg General Health questionnaire. Subjective and normative health conditions were evaluated and logistic regression was applied (OR/CI95%) with a 5% significance level. The survey included 419 elderly residents and the prevalence of mental disorders was 44.6%. The presence of mental disorders was greater among seniors who reported dissatisfaction with life, impairment in the mental and physical control of quality of life and with self-perception of the appearance of teeth and gums as negative. The prevalence of disorders was less identified between men and among those for whom oral health did not affect their relationships with other people The common mental disorder was identified in a significant number of the elderly investigated and the presence of this disorder has been mainly associated with oral health conditions.

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