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Magallanes-Perdomo M.,Institute Ceramica Y Vidrio Icv Csic C Kelsen 5 | Luklinska Z.B.,Queen Mary, University of London | De Aza A.H.,Institute Ceramica Y Vidrio Icv Csic C Kelsen 5 | Carrodeguas R.G.,Institute Ceramica Y Vidrio Icv Csic C Kelsen 5 | And 2 more authors.
Journal of the European Ceramic Society | Year: 2011

This research describes the preparation, characterisation and in vitro behavior of a bioactive glass ceramic containing 44.8wt% apatite, 28.0wt% wollastonite-2M and 27.2wt% of amorphous phase. The biomaterial was obtained by a specific thermal cycle process that caused the devitrification of the Ca 3(PO 4) 2-CaSiO 3 binary system's stoichiometric eutectic composition. Overall, the material combines the properties of a resorbable Si-Ca-rich glass, in addition to bioactive properties of wollastonite and apatite phases. The bioactivity of this material was studied by soaking the samples in a simulated body fluid (SFB) for 3, 7, 14 and 21 days at 36.5°C. During the soaking, the amorphous phase and also wollastonite-2M phase underwent steady dissolution by releasing Si and Ca ions into the SBF medium. After 7 days, a porous hydroxy-carbonate apatite (HCA) layer was formed at the SBF-glass ceramic interface. The micro-nanostructured apatite-wollastonite-2M glass ceramics with improved mechanical properties, in comparison with the parent glass, could serve as a promising platform for hard tissue regeneration. © 2011 Elsevier Ltd.

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