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Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: NMP-29-2015 | Award Amount: 6.33M | Year: 2016

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.


Grant
Agency: Cordis | Branch: H2020 | Program: SGA-RIA | Phase: FETFLAGSHIP | Award Amount: 89.00M | Year: 2016

This project is the second in the series of EC-financed parts of the Graphene Flagship. The Graphene Flagship is a 10 year research and innovation endeavour with a total project cost of 1,000,000,000 euros, funded jointly by the European Commission and member states and associated countries. The first part of the Flagship was a 30-month Collaborative Project, Coordination and Support Action (CP-CSA) under the 7th framework program (2013-2016), while this and the following parts are implemented as Core Projects under the Horizon 2020 framework. The mission of the Graphene Flagship is to take graphene and related layered materials from a state of raw potential to a point where they can revolutionise multiple industries. This will bring a new dimension to future technology a faster, thinner, stronger, flexible, and broadband revolution. Our program will put Europe firmly at the heart of the process, with a manifold return on the EU investment, both in terms of technological innovation and economic growth. To realise this vision, we have brought together a larger European consortium with about 150 partners in 23 countries. The partners represent academia, research institutes and industries, which work closely together in 15 technical work packages and five supporting work packages covering the entire value chain from materials to components and systems. As time progresses, the centre of gravity of the Flagship moves towards applications, which is reflected in the increasing importance of the higher - system - levels of the value chain. In this first core project the main focus is on components and initial system level tasks. The first core project is divided into 4 divisions, which in turn comprise 3 to 5 work packages on related topics. A fifth, external division acts as a link to the parts of the Flagship that are funded by the member states and associated countries, or by other funding sources. This creates a collaborative framework for the entire Flagship.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-ITN-ETN | Phase: MSCA-ITN-2015-ETN | Award Amount: 2.81M | Year: 2016

PANDORA (Probing safety of nano-objects by defining immune responses of environmental organisms) shall assess the global impact of engineered nanoparticles (NP) on the immune responses of representative organisms covering all evolutionary stages and hierarchical levels from plants to invertebrates and vertebrates. Immunity is a major determinant of the survival and fitness of all living organisms, therefore immunosafety of engineered NP is a key element of environmental nanosafety. PANDORA will tackle the issue of global immunological nanosafety by comparing the impact of widely-used NP (e.g., iron, titanium and cerium oxide) on the human immune response with their effects in representative terrestrial and marine organisms. This comparison will focus on the conserved system of innate immunity/stress response/inflammation, aiming to identify common mechanisms and markers across immune defence evolution shared by plants (Arabidopsis), invertebrate (bivalves, echinoderms, earthworms), and vertebrate (human) species. PANDORAs objectives are: 1. To identify immunological mechanisms triggered by nano-objects, and predictive markers of risk vs. safety; 2. To do so by a collaborative cross-species comparison, from plants to human, of innate immune defence capacity, using selected, industrially-relevant NP; 3. To design predictive in vitro assays to measure the immuno-risk of NP to the environment and human health, as new approaches to industrial and environmental nanosafety testing. PANDORA will train 11 PhD students in an overarching training programme involving training-by-research, joint courses of technical, scientific and transferrable skills, participation to public scientific events, and an intense intersectoral networking exchange plan. The PANDORA consortium encompasses academic institutions, research centres, and SMEs, all with proven experience in higher education and training, and state-of-the art scientific and technical expertise and infrastructures.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: WATER-1b-2015 | Award Amount: 8.77M | Year: 2016

INTCATCH will instigate a paradigm shift in the monitoring and management of surface water quality that is fit for global waters in the period 2020-2050. INTCATCH will do this by developing efficient, user-friendly water monitoring strategies and systems based on innovative technologies that will provide real time data for important parameters, moving towards SMART Rivers. The business model will transform water governance by facilitating sustainable water quality management by community groups and NGOs using a clouds data linked to a decision support system and eco-innovative technologies. The INTCATCH project will use demonstration activities to showcase eco-innovative autonomous and radio controlled boats, sensors, DNA test kits and run-off treatment technologies. Actions which develop and evaluate these in a range of catchments will address the important innovation barriers to uptake, notably, a lack of knowledge of new technologies and their capabilities, identified by the European Innovation Plan (EIP) on water. By conceptually moving the laboratory to the field, the monitoring techniques that will be developed aim to supersede the inefficient, time dependent, costly and labour-intensive routine sampling and analysis procedures currently deployed to understand the quality of receiving waters. It will compliment routine monitoring that is required for baseline datasets, but also enable cost-effective impact and management investigations. INTCATCH will incentivise stakeholder innovation in monitoring and will facilitate new financing for innovation through its innovative franchise business model and empowerment of community groups and NGOs. The market ambition is that the INTCATCH business will facilitate an eco-innovative approach to deliver good quality water bodies across Europe and beyond. This will support green growth, increase resilience to climate change and capture greater market-share for Europes innovative industries.


Grant
Agency: Cordis | Branch: H2020 | Program: MSCA-RISE | Phase: MSCA-RISE-2016 | Award Amount: 1.10M | Year: 2017

We are proposing a 4-year program of knowledge transfer and networking between Aston University, UK (Aston), Cork Institute of Technology, Ireland (CIT), Institute of Nanoscience and Nanotechnology, Spain (ICN2), University of Birmingham, UK (UoB), Zhejiang University of Technology, China (ZJUT), Nanotechplamsa Ltd, Bulgaria (NPL), B&T composites, Greece (B&T), National Institute for Research and Development in Electrical Engineering, Romania (ICPESA), and Teer Coatings Ltd, UK (TCL). The objective of the proposed joint exchange programme is to establish long-term stable research cooperation between the partners with complimentary expertise and knowledge. The project objectives and challenges present a balanced mix between industrial application focused knowledge transfer and development and more far-looking studies for potentially ground-breaking applications of using diamond-based nanomaterials and nanostructures for advanced electronic and photonic applications (D-SPA), including fabrication of diamond nanostructures using 3D printing technology, development of diamond-plasmon hybrid photonic devices and development of biophotonic imaging technology for sensing applications. No one group in Europe can accomplish each work package alone. We have to collaborate with each other in order to gain their skills and expertise in these specific areas.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: INFRAIA-1-2014-2015 | Award Amount: 11.76M | Year: 2015

NFFA-EUROPE will implement the first open-access research infrastructure as a platform supporting comprehensive projects for multidisciplinary research at the nanoscale extending form synthesis to nanocharacterization to theory and numerical simulation. The integration and the extension of scope of existing specialized infrastructures within an excellence network of knowledge and know-how will enable a large number of researchers from diverse disciplines to carry out advanced proposals impacting science and innovation. The full suite of key infrastructures for nanoscience will become, through the NFFA-EUROPE project, accessible to a broader community extended to research actors operating at different levels of the value chain, including SMEs and applied research, that are currently missing the benefits of these enabling technologies. NFFA-EUROPE sets out to offer an integrated, distributed infrastructure to perform comprehensive nanoscience and nanotechnology projects from synthesis and nanolithography (with nanofoundry installations) to advanced characterization and theoretical modellization/numerical simulation (with experimental installations including analytical large scale facilities and a distributed theoretical installation including high-performance computing). Coordinated access will be given to complementary facilities co-located in nine well distributed main sites in Europe, ensuring the optimal match between user proposal and technical offer. The research activity of the Consortium will realize innovative solutions on key bottlenecks of nanoscience research, therefore upgrading the facility quality and uniqueness.


Grant
Agency: Cordis | Branch: H2020 | Program: IA | Phase: PILOTS-02-2016 | Award Amount: 5.68M | Year: 2017

FLEXPOL aims to develop a pilot line for the production of a cost effective antimicrobial (AM) adhesive film for its use in hospitals. The obtained adhesive film will inhibit growth of a wide range of microbes and will be suitable for high-touch surfaces, providing a durable protection with good resistance. It will assure the highest level of hygiene and patient safety, reducing the use of disinfectants. These objectives will be achieved, using a multi-functional approach combining prevention of adhesion with killing of microorganisms, by means of essential oil (EO) emulsions embedded in a micro and nanopatterned polypropylene matrix. FLEXPOL covers the following key aspects: -It addresses the development, upscaling and demonstration in a relevant industrial environment of the production of films with AM, biocompatible and anti-adhesive properties. Existing extrusion and nanoimprinting pilot lines will act as the starting point in which new additives based on blends of EO will be incorporated. -Previously validated technologies constitute the basis of the approach. These technologies will be extended to large scale production and demonstrated in a real operational environment. The pilot line will include real time characterization for inspection of the film at the nanoscale. -Robustness and repeatability of film fabrication and its behavior in a real environment will be studied. The effectiveness of the solution will be compared with standard protocols. -Materials are chosen according to their cost for large-scale application. Productivity and cost of the fabrication process will be analyzed attending to energetic optimization of the product fabrication and the raw material cost. -Access to the pilot line for AM films in this or a different application will be ensured to European Industries at a cost that promotes technology transfer. -Non-technological aspects key for the marketing of the product (such as regulatory issues, HSE aspects, LCA...) are considered.


Grant
Agency: Cordis | Branch: H2020 | Program: CSA | Phase: FETOPEN-02-2016 | Award Amount: 670.00K | Year: 2017

This FET-open Coordination and Support Action is called Nanoarchitectronics (NTX) to denote a new interdisciplinary research area at the crossroad of Electromagnetics and Nanoelectronics. NTX It is a new technology aimed at conceiving, designing and developing reconfigurable, adaptive and cognitive structures, sensorial surfaces and functional skins with unique physical properties, and engineering applications in the whole electromagnetic spectrum; through assembling building blocks at nanoscale in hierarchical architectures. The conception of this new area responds to the need of unifying concepts, methodologies and technologies in Communications, Environment Sensing Systems, Safety and Security, Bio-Sensing Systems and Imaging Nanosystems, within a wide frequency range. This FET project proposal gathers thirteen universities, research centers and high-tech industries, belonging to eight European countries. According to the FET work-program, the major objective of Nanoarchitectronics is to boost the future application-driven research through the establishment of an accepted language among physicists and engineers, a shared way of thinking, a common theoretical foundation and a common strategy for the future. Therefore, the project aims at laying the foundation for an ever-increasing synergy and progress of Nanoarchitectronics. To achieve these objectives, Nanoarchitectronics is structured in four main activities. The Concept activity is devoted to establish and define the concepts of Nanoarchitectronics and its boundaries with respect to other disciplines and to the activity carried out by other consortia. The Strategy activity identifies the policy dialogue and the strategic view of the consortium in terms of position, impact and vision. The Virtual Networking serves to internal web communication (private), and for dissemination (public). The Dissemination and Exploitation activity is carried out mainly by the industrial partners of the consortium


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: FETPROACT-01-2016 | Award Amount: 8.65M | Year: 2016

The goal of BrainCom is to develop a new generation of neuroprosthetic devices for large-scale and high density recording and stimulation of the human cortex, suitable to explore and repair high-level cognitive functions. Since one of the most invalidating neurospychological conditions is arguably the impossibility to communicate with others, BrainCom primarily focuses on the restoration of speech and communication in aphasic patients suffering from upper spinal cord, brainstem or brain damage. To target broadly distributed neural systems as the language network, BrainCom proposes to use novel electronic technologies based on nanomaterials to design ultra-flexible cortical and intracortical implants adapted to large-scale high-density recording and stimulation. The main challenge of the project is to achieve flexible contact of broad cortical areas for stimulation and neural activity decoding with unprecedented spatial and temporal resolution. Critically, the development of such novel neuroprosthetic devices will permit significant advances to the basic understanding of the dynamics and neural information processing in cortical speech networks and the development of speech rehabilitation solutions using innovative brain-computer interfaces. Beyond this application, BrainCom innovations will enable the study and repair of other high-level cognitive functions such as learning and memory as well as other clinical applications such as epilepsy monitoring using closed-loop paradigms. BrainCom will be carried out by a consortium assembled to foster the emergence of a new community in Europe acting towards the development of neural speech prostheses. Thanks to its high interdisciplinarity involving technology, engineering, biology, clinical sciences, and ethics, BrainCom will contribute advances to all levels of the value chain: from technology and engineering to basic and language neuroscience, and from preclinical research in animals to clinical studies in humans.

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