Institute Cardiologia Of Cruz Alta Icca

Cruz Alta, Brazil

Institute Cardiologia Of Cruz Alta Icca

Cruz Alta, Brazil
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Hirsch G.E.,University of Cruz Alta | Hirsch G.E.,Institute Cardiologia Of Cruz Alta Icca | Viecili P.R.N.,University of Cruz Alta | Viecili P.R.N.,Institute Cardiologia Of Cruz Alta Icca | And 16 more authors.
Current Pharmaceutical Design | Year: 2017

Background: Complex hemostatic mechanisms are involved in the pathophysiology of various diseases, including cardiovascular diseases. Among them, dysregulation of platelet activity is linked to the progression of atherosclerosis and mainly involves platelet aggregation and a decrease in blood flow in the vascular endothelium. The major platelet activation pathways mediated by agonists involve the arachidonic acid pathway, adenosine diphosphate pathway, serotonin pathway, nitric oxide pathway, and action of free radicals on molecules involved in platelet aggregation. These mechanisms have been widely studied and discussed because they are inhibited by the use of medicinal plants in complementary and alternative medicine, thus reducing platelet aggregation. Results: Of the main plants discussed in this review, which have antiplatelet activity, some include saffron, garlic, green tea, St. John’s wort, ginger, ginkgo biloba, ginseng, and guavirova. These herbal medicines have phytochemical components, which are directly related to the antiplatelet activity of the plant, such as flavonoids, curcumins, catechins, terpenoids, polyphenols, and saponins. While the majority of the medicinal plants mentioned here were native to the Asian continents, some are distributed worldwide, and found to a smaller extent throughout the American continent, European continent, Mediterranean, African continent, and the Middle East. Conclusion: This review showed that several plants and/or compounds exhibit anti-platelet activity, and are therefore potential research targets for developing drugs to treat diseases related to aggregation disorders. © 2017 Bentham Science Publishers.


Otero J.S.,University of Cruz Alta | Otero J.S.,Institute Cardiologia Of Cruz Alta Icca | Hirsch G.E.,University of Cruz Alta | Hirsch G.E.,Institute Cardiologia Of Cruz Alta Icca | And 23 more authors.
Thrombosis Research | Year: 2017

Background and aims Cardiovascular diseases of thrombotic origin are related to high mortality and standard therapeutic agent used in this case is acetylsalicylic acid (ASA), but serious adverse events may occur. However, recent data has suggested the plant Campomanesia xanthocarpa has antiplatelet activity and could be a viable alternative. In this study we investigated the effects of the encapsulated powder of this plant in human platelet aggregation. Methods 23 healthy subjects were randomly divided into three groups: (1) ASA (100 mg), (2) C. xanthocarpa (1000 mg) or (3) synergism (500 mg of C. xanthocarpa plush 50 mg of ASA); daily for five days. Antiplatelet activity was determined by turbidimetric method using ADP or arachidonic acid (AA) agonists before, 5 and 8 days after treatments. Results Treatment with C. xanthocarpa and synergism caused a reduction of 8 ± 13.5% and 12.5 ± 5% in platelet aggregation induced by ADP after 5 days of treatment, respectively, returning to basal levels after 8 days. For AA agonist, 5 days of treatment with C. xanthocarpa, ASA or synergism caused a reduction of 46 ± 15%, 36 ± 12% and 69.3 ± 6% in platelet aggregation, respectively, and first two groups returned to baseline values 8 days after treatment ended. Synergism group prolonged antiplatelet effect maintaining aggregation reduction after 8 days the end of treatment. Conclusion C. xanthocarpa showed antiplatelet action when stimulated by agonist AA, and contributed to the antiplatelet effect when associated with ASA for both agonists, allowing dose reduction to 50 mg. © 2017 Elsevier Ltd


Klafke J.Z.,University of Cruz Alta | Klafke J.Z.,Institute Cardiologia Of Cruz Alta Icca | Pereira R.L.D.,University of Cruz Alta | Pereira R.L.D.,Institute Cardiologia Of Cruz Alta Icca | And 24 more authors.
Phytomedicine | Year: 2015

Background:: Atherosclerosis is an inflammatory disease that affects the arterial wall leading to myocardial, cerebral, and peripheral ischemic syndromes. The use of low doses of aspirin inhibits platelet aggregation and inflammation and prevents cardiovascular mortality. However, ASA may produce hemorrhagic events. Thus, several studies have sought new natural compounds to suppress platelet aggregation without causing serious adverse effects. Purpose:: In this sense, this study aims to compare the effects of Campomanesia xanthocarpa plant extract with those of acetylsalicylic acid (ASA) on inflammatory parameters observed in homozygous mice knockout for the low-density lipoprotein receptor (LDLr-KO) treated with a hypercholesterolemic diet. Material and Methods:: In this study, 28 male LDLr-KO mice were divided into three groups and fed a hypercholesterolemic diet for 4 weeks. Thereafter, the animals that received the hypercholesterolemic diet were treated for 5 days with (1) distilled water, (2) C. xanthocarpa extract, or (3) acetylsalicylic acid. The levels of inflammatory markers were assessed in the blood samples. The gastric tolerability of the animals after oral administration of the treatments was assessed through quantification of the lesions in the gastric mucosa. Results:: The levels of proinflammatory cytokines IL-1, IL-6, TNF-α, and INF-γ were reduced to 19.2 ± 3%, 20.4 + 1.3%, 24.7 ± 1.2%, and 20.8 ± 1.7%, respectively, in the group treated with C. xanthocarpa, when compared to control group. Furthermore, treatment with plant extract significantly increased the levels of the anti-inflammatory cytokine IL-10 by 27.3 ± 5.9%, but ASA showed no significant effect on the same cytokines when compared to the control group, with the exception of IL-10, which presented an increase of 8.6 ± 3.5%. Treatments with C. xanthocarpa and ASA also caused significant reductions of 26.4 ± 3% and 38.4± 6% in the serum levels of oxLDL, respectively. However, only treatment with C. xanthocarpa reduced the levels of anti-oxLDL antibodies when compared with the control (25.8 ± 6%). In addition, the analyzed extract did not induce ulcerogenic activity, while ASA induced the formation of lesions. Conclusion:: In conclusion, treatment with C. xanthocarpa causes anti-inflammatory activity in hypercholesterolemic animals, with results superior to those obtained with the use of ASA. © 2015.


Bundchen D.C.,Institute Cardiologia Of Cruz Alta Icca | Panigas C.F.,Institute Cardiologia Of Cruz Alta Icca | Dipp T.,Institute Cardiologia Of Cruz Alta Icca | Panigas T.F.,Institute Cardiologia Of Cruz Alta Icca | And 4 more authors.
Arquivos Brasileiros de Cardiologia | Year: 2010

Background: Hypertension (H) is associated with a large number of co-morbidities, including obesity. The correlation between two variables has been investigated. Objective: To analyze the correlation between the loss of body mass and blood pressure reduction in hypertensive patients undergoing exercising programs (EP). Methods: One hundred eleven hypertensive patients with overweight or obesity were randomly divided into an experimental group (EG). Out of these, 57 (58 ± 8.9 years old) participated in a three-month EP conducted three times a week in aerobic exercise sessions from 50% to 70% of VO2 peak for 30 to 60 minutes and resistance exercises; and a control group (CG) with 54 (60 ± 7.7 years old) who did not participate in the EP. In the EG, blood pressure (BP) was measured before each session and the measurement of anthropometric variables (AV) at the beginning of the program and after three months. In the CG the BP and the VA were evaluated in the doctor's office at the beginning and at the end of the study. Data were expressed as mean ± standard deviation (SD). Pearson correlation and t test were used. A value of p < 0.05 was considered significant. Results: In the CG there was no significant difference in AV and BP at the beginning and at the end of the study. In the EG, there was no significant alteration in the AV, however, there was blood pressure reduction of 12% in systolic BP (-17.5 mmHg, p = 0.001) and 9% in Diastolic BP (-8.1 mmHg, p = 0. 01) at the end of the study. There was no correlation between the AV and decrease in BP (r = 0.1). Conclusion: The blood pressure reduction was not correlated with reduction of anthropometric measures after the exercising period.

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