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Anschau F.,Institute Cardiologia Do Rio Grande Do sul | Guimaraes Goncalves M.A.,Grande Rio University
Acta Cytologica | Year: 2011

Objective: Since cytology is the examination utilized for the screening of cervical cancer, it is important to determine its correlation with histologic examination, the gold standard in the diagnosis of cervical disease. Study Design: A retrospective evaluation was made of 431 patients who presented with colposcopic indication for cervical biopsy between 2003 and 2007. Results: In 90.8% (289/318) of the patients, cytology showing cervical intraepithelial neoplasia (CIN) was confirmed as CIN in the histology of the cervix, while 62.8% (71/113) of patients with normal cytology had a confirmation of a normal histology (κ = 0.558). Conclusion: Cytology demonstrated a sensitivity and specificity of 87.3 and 71.0%, respectively. The agreement between cervical cytology and histology, considering the presence of CIN, was moderate. Correlations between accuracy and errors of cytology are discussed with therapeutic emphasis. Copyright © 2011 S. Karger AG, Basel. Source

Passos-Silva D.G.,Federal University of Minas Gerais | Brandan E.,University of Santiago de Chile | Santos R.A.S.,Federal University of Minas Gerais | Santos R.A.S.,Institute Cardiologia Do Rio Grande Do sul
Trends in Pharmacological Sciences | Year: 2015

The renin-angiotensin system (RAS) plays a pivotal role in cardiovascular and hydro-electrolyte homeostasis. Blockade of the RAS as a therapeutic strategy for treating hypertension and related cardiovascular diseases is well established. However, actions of the RAS go far beyond the targets initially described. In this regard, the recent identification of novel components of the RAS, including angiotensin-(1-7) [Ang-(1-7)], Ang-(1-9), and alamandine, have opened new possibilities for interfering with the development and manifestations of cardiovascular and non-cardiovascular diseases. In this article, we briefly review novel targets for angiotensins and its therapeutic implications in diverse areas, including cancer, inflammation, and glaucoma. © 2015 Elsevier Ltd. All rights reserved. Source

Mastalir E.T.,Institute Cardiologia Do Rio Grande Do sul | Carvalhal G.F.,Pontifical Catholic University of Rio Grande do Sul | Portal V.L.,Cardiology Division from Institute Cardiologia Do Rio Grande Do sul
International Journal of Impotence Research | Year: 2011

The aim of the study is to evaluate the effect of simvastatin in erectile dysfunction (ED) secondary to endothelial dysfunction. This study is a double-blind, randomized, placebo-controlled, clinical trial in patients with ED and endothelial dysfunction. Patients were randomized to receive 20 mg simvastatin (n=21) or placebo (n=20) daily for 6 months and subsequently 10 mg of vardenafil on demand for 4 weeks. Serum cholesterol, hormone profile, ultrasensitive C-reactive protein, the International Index of Erectile Dysfunction (IIEF) and the ED Index of Treatment Satisfaction were evaluated. There was a significant reduction in serum cholesterol in the treatment group. The hormonal profile remained unaltered. There was no difference in the IIEF between the groups at follow-up, although, at the beginning, 26% of the patients of both groups presented with mild ED and 74% with moderate-to-severe ED; at the end of the 7th month, all patients from the simvastatin group progressed to mild ED, compared with only 83% in the placebo group. There was no statistically significant difference in penile erection after intake of simvastatin or placebo. This study does not support the use of simvastatin as erectogenic medication. Further studies are necessary to verify if simvastatin has any beneficial effect on ED. © 2011 Macmillan Publishers Limited All rights reserved. Source

Villela D.C.,Federal University of Minas Gerais | Passos-Silva D.G.,Federal University of Minas Gerais | Santos R.A.S.,Federal University of Minas Gerais | Santos R.A.S.,Institute Cardiologia Do Rio Grande Do sul
Current Opinion in Nephrology and Hypertension | Year: 2014

Purpose of review In this article, we review the recent findings regarding a new derivative of angiotensin-(1-7) [Ang-(1-7)], alamandine, and its receptor, the Mas-related G-coupled receptor type D (MrgD) with a special emphasis on its role and how it can be formed. Recent findings Over the last decade, there have been significant conceptual changes regarding the understanding of the renin-angiotensin system (RAS). A cardioprotective axis has been elucidated by the discovery of the Mas receptor for the biologically active Ang-(1-7), and the angiotensin-converting enzyme 2 (ACE2) that coverts Ang II into Ang-(1-7). In addition, several components of the system, such as Ang-(1-12), Angiotensin A (Ang A) and the newly discovered peptide, alamandine, have been identified. Alamandine is generated by catalysis of Ang A via ACE2 or directly from Ang-(1-7). Summary Alamandine is a vasoactive peptide with similar protective actions as Ang-(1-7) that acts through the MrgD and may represent another important counter-regulatory mechanism within the RAS. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Source

Favretto D.C.,Centro Universitario Univates | Pontin B.,Institute Cardiologia Do Rio Grande Do sul | Moreira T.R.,Federal University of Rio Grande do Sul
Arquivos de Gastroenterologia | Year: 2013

Context - Constipation is a very common symptom in the general population. One way of non-pharmacological treatment of constipation is through the addition of probiotics to food. Objectives - The aim of this study was to evaluate de effect of the consumption of a fresh cheese, enriched with Bifdobacterium lactis Bi-07 on the symptoms of constipated women. Methods - A randomized controlled trial, carried out in the Basic Health Units of Guaporé's City - RS/Brazil, between january and may 2012, with 30 constipated women. The patients were randomized into two groups whom received, for 30 days, 30 g of fresh cheese enriched with Bifdobacterium lactis Bi-07 (n = 15) or regular fresh cheese (n = 15). Constipation symptoms were evaluated according to ROMA III Consensus, before and after the nutritional intervention. Also, data of clinical and anthropometric characteristics of the individuals were collected. Accepted level of significance 5% (P≤0,05). Results - The medium age of the studied population was 37,5±14,4 years in the intervention group and 40,8±12,8 years in the control group. After 30 days we observed that the ingestion of fresh cheese enriched with Bifdobacterium lactis Bi-07 promoted benefic effects on the symptoms of strength to evacuate. Conclusion - The consumption of 30g/day of a fresh cheese enriched with Bifdobacterium lactis Bi-07 has beneficial effects on constipation symptoms. Source

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