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Lopez-Jaramillo C.,University of Antioquia | Vargas C.,University of Antioquia | Diaz-Zuluaga A.M.,University of Antioquia | Palacio J.D.,University of Antioquia | And 3 more authors.
Bipolar Disorders | Year: 2017

Objective: Magnetic resonance imaging (MRI) studies in bipolar I disorder (BD-I) suggest that lithium is associated with increased volumes of cortico-limbic structures. However, more rigorous control of confounding factors is needed to obtain further support for this hypothesis. The aim of the present study was to assess differences in brain volumes among long-term lithium-treated BD-I patients, unmedicated BD-I patients, and healthy controls. Methods: This was a cross-sectional study with 32 euthymic BD-I patients (16 on lithium monotherapy for a mean of 180 months, and 16 receiving no medication for at least the 2 months prior to the study) and 20 healthy controls. Patients were euthymic (Hamilton Depression Rating Scale [HDRS] <6 and Young Mania Rating Scale [YMRS] <7) and had not taken psychotropic medications other than lithium for at least 6 months. Brain images were acquired on a 1.5 Tesla MRI (Phillips, Amsterdam, The Netherlands) and segmented to generate volumetric measures of cortical and subcortical brain areas, ventricles and global brain. Results: Significant differences were found in the volumes of the left amygdala (P=.0003), right amygdala (P=.030), left hippocampus (P=.022), left thalamus (P=.022), and right thalamus (P=.019) in long-term lithium-treated BD-I patients, compared to unmedicated patients and controls, after multivariable adjustment. No differences were observed in global brain volume or in ventricular size among the three groups. Likewise, there was no correlation between serum lithium levels and the increase in size in the described brain areas. Conclusions: The structural differences found among the three groups, and specifically those between long-term lithium-treated and unmedicated BD-I patients, indicate increased limbic structure volumes in lithium-treated patients. © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


Quiroz Y.T.,Boston University | Quiroz Y.T.,University of Antioquia | Budson A.E.,Boston University | Budson A.E.,Edith Nourse Rogers Memorial Veterans Hospital | And 6 more authors.
Annals of Neurology | Year: 2010

Objective: The examination of individuals who carry fully penetrant genetic alterations that result in familial Alzheimer's disease (FAD) provides a unique model for studying the early presymptomatic disease stages. In AD, deficits in episodic and associative memory have been linked to structural and functional changes within the hippocampal system. This study used functional MRI (fMRI) to examine hippocampal function in a group of healthy, young, cognitively-intact presymptomatic individuals (average age 33.7 years) who carry the E280A presenilin-1 (PS1) genetic mutation for FAD. These PS1 subjects will go on to develop the first symptoms of the disease around the age of 45 years. Our objective was to examine hippocampal function years before the onset of clinical symptoms. Methods Twenty carriers of the Alzheimer's-associated E280A PS1 mutation and 19 PS1-negative control subjects participated. Both groups were matched for age, sex, education level, and neuropsychological test performance. All participants performed a face-name associative encoding task while in a Phillips 1.5T fMRI scanner. Analysis focused on the hippocampal system. Results Despite identical behavioral performance, presymptomatic PS1 mutation carriers exhibited increased activation of the right anterior hippocampus during encoding of novel face-name associations compared to matched controls. Interpretation Our results demonstrate that functional changes within the hippocampal memory system occur years before cognitive decline in FAD. These presymptomatic changes in hippocampal physiology in FAD suggest that hippocampal fMRI patterns during associative encoding may also provide a preclinical biomarker in sporadic AD. Copyright © 2010 American Neurological Association.


Quiroz Y.T.,University of Antioquia | Quiroz Y.T.,Massachusetts General Hospital | Willment K.C.,Brigham and Women's Hospital | Castrillon G.,Institute Alta Tecnologia Medica IATM | And 5 more authors.
Journal of Alzheimer's Disease | Year: 2015

Background: Brain regions critical to episodic memory are altered during the preclinical stages of Alzheimer's disease (AD). However, reliable means of identifying cognitively-normal individuals at higher risk to develop AD have not been established. Objective: To examine whether functional MRI can detect early functional changes associated with scene encoding in a group of presymptomatic presenilin-1 (PSEN1) E280A mutation carriers. Methods: Participants were 39 young, cognitively-normal individuals from an autosomal dominant early-onset AD kindred, located in Antioquia, Colombia. Participants performed a functional MRI scene encoding task and a post-scan subsequent memory test. Results: PSEN1 mutation carriers exhibited hyperactivation within medial temporal lobe regions (hippocampus, parahippocampal formation) during successful scene encoding compared to age-matched non-carriers. Conclusion: Hyperactivation in medial temporal lobe regions during scene encoding is seen in individuals genetically-determined to develop AD years before their clinical onset. Our findings will guide future research with the ultimate goal of using functional neuroimaging in the early detection of preclinical AD. © 2015 - IOS Press and the authors. All rights reserved.


PubMed | Clinica Medellin, University of Saskatchewan, Institute Alta Tecnologia Medica IATM, Hospital Universitario San Vicente Fundacion and University of Antioquia
Type: Journal Article | Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion | Year: 2016

Magnetic resonance imaging is an essential tool in the pre-surgical evaluation of patients with drug-resistant epilepsy.Our aim was to assess the value of re-imaging patients with focal drug-resistant epilepsy.Thirty patients with negative or non-conclusive 1.5 Tesla magnetic resonance imaging were rescanned with 1.5T and 3T. All of them had previous 1.5 scans with no seizure protocol in a non-specialized center. Two neuroradiologists who were blinded to prior imaging results randomly reviewed the magnetic resonance images. Kappa score was used to assess the reliability.Mean age of patients was 30 (SD 11) years. The intra-observer agreement for the first radiologist was 0.74 for 1.5T and 0.71 for 3T. In the second radiologist it was 0.82 and 0.66, respectively. Three lesions (10%) were identified by general radiologists in non-specialized centers using a 1.5T standard protocol. In our center a consensus between two neuroradiologists using epilepsy protocol identified seven lesions (23%) using 1.5T and 10 (33%) using 3T (p < 0.01). In 28% of patients this additional information resulted in a change in clinical management.3T magnetic resonance imaging rescanning improves the diagnostic yield in patients with focal epilepsy and previous negative 1.5T magnetic resonance imaging. Use of 3T magnetic resonance imaging, epilepsy protocols, and interpretation by experienced neuroradiologists is highly recommended.


PubMed | Boston University, Brigham and Women's Hospital, Institute Alta Tecnologia Medica IATM and University of Antioquia
Type: Journal Article | Journal: Journal of Alzheimer's disease : JAD | Year: 2015

Brain regions critical to episodic memory are altered during the preclinical stages of Alzheimers disease (AD). However, reliable means of identifying cognitively-normal individuals at higher risk to develop AD have not been established.To examine whether functional MRI can detect early functional changes associated with scene encoding in a group of presymptomatic presenilin-1 (PSEN1) E280A mutation carriers.Participants were 39 young, cognitively-normal individuals from an autosomal dominant early-onset AD kindred, located in Antioquia, Colombia. Participants performed a functional MRI scene encoding task and a post-scan subsequent memory test.PSEN1 mutation carriers exhibited hyperactivation within medial temporal lobe regions (hippocampus,parahippocampal formation) during successful scene encoding compared to age-matched non-carriers.Hyperactivation in medial temporal lobe regions during scene encoding is seen in individuals genetically-determined to develop AD years before their clinical onset. Our findings will guide future research with the ultimate goal of using functional neuroimaging in the early detection of preclinical AD.


Ladino L.D.,University of Antioquia | Ladino L.D.,Institute Alta Tecnologia Medica IATM | Delgado De Bedout J.A.,Institute Alta Tecnologia Medica IATM | Lopez Rios A.L.,Hospital Universitario San Vicente Fundacion | Arango Viana J.C.,University of Antioquia
Neurologia Argentina | Year: 2013

Background: The jugular paraganglioma is a rare tumor of head and neck. Case report: 34 year old woman with a long standing jugular paraganglioma with extracranial and intracranial component that occupies much of the posterior fossa, this compress the stem and the cerebellum, we conducted a clinical, imaging and histopathologic correlation. The identification of the tumor showed typical findings in salt and pepper on both magnetic resonance sequences and histological sections. Conclusions: The jugular paraganglioma is histologically a benign tumor, but its progressive growth, may compromise important intracranial structures. © 2012 Sociedad Neurológica Argentina. Published by Elsevier España, S.L. All rights reserved.


Pineda Zapata J.A.,Institute Alta Tecnologia Medica IATM | Delgado De Bedout J.A.,Institute Alta Tecnologia Medica IATM | Rascovsky Ramirez S.,Institute Alta Tecnologia Medica IATM | Bustamante C.,Institute Alta Tecnologia Medica IATM | And 2 more authors.
Radiologia | Year: 2014

The 4D Flow MRI technique provides a three-dimensional representation of blood flow over time, making it possible to evaluate the hemodynamics of the cardiovascular system both qualitatively and quantitatively. In this article, we describe the application of the 4D Flow technique in a 3 T scanner; in addition to the technical parameters, we discuss the advantages and limitations of the technique and its possible clinical applications. We used 4D Flow MRI to study different body areas (chest, abdomen, neck, and head) in 10 volunteers. We obtained 3D representations of the patterns of flow and quantitative hemodynamic measurements. The technique makes it possible to evaluate the pattern of blood flow in large and midsize vessels without the need for exogenous contrast agents. © 2013 SERAM. Published by Elsevier España, S.L.U. All rights reserved.


PubMed | CES University and Institute Alta Tecnologia Medica IATM
Type: Journal Article | Journal: Radiologia | Year: 2014

The 4D Flow MRI technique provides a three-dimensional representation of blood flow over time, making it possible to evaluate the hemodynamics of the cardiovascular system both qualitatively and quantitatively. In this article, we describe the application of the 4D Flow technique in a 3T scanner; in addition to the technical parameters, we discuss the advantages and limitations of the technique and its possible clinical applications. We used 4D Flow MRI to study different body areas (chest, abdomen, neck, and head) in 10 volunteers. We obtained 3D representations of the patterns of flow and quantitative hemodynamic measurements. The technique makes it possible to evaluate the pattern of blood flow in large and midsize vessels without the need for exogenous contrast agents.


Bustamante C.,Institute Alta Tecnologia Medica IATM | Pineda J.,Institute Alta Tecnologia Medica IATM | Rascovsky S.,Institute Alta Tecnologia Medica IATM | Arango A.,Institute Alta Tecnologia Medica IATM
Journal of Digital Imaging | Year: 2016

The administration of a DICOM network within an imaging healthcare institution requires tools that allow for monitoring of connectivity and availability for adequate uptime measurements and help guide technology management strategies. We present the implementation of an open-source widget for the Dashing framework that provides basic dashboard functionality allowing for monitoring of a DICOM network using network “ping” and DICOM “C-ECHO” operations. © 2016 Society for Imaging Informatics in Medicine


PubMed | Institute Alta Tecnologia Medica IATM
Type: Journal Article | Journal: Journal of digital imaging | Year: 2016

The administration of a DICOM network within an imaging healthcare institution requires tools that allow for monitoring of connectivity and availability for adequate uptime measurements and help guide technology management strategies. We present the implementation of an open-source widget for the Dashing framework that provides basic dashboard functionality allowing for monitoring of a DICOM network using network ping and DICOM C-ECHO operations.

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