Zou S.,China Agricultural University |
Zou S.,Inspection and Testing Center for Genetically Modified Organisms |
Huang K.,China Agricultural University |
Huang K.,Inspection and Testing Center for Genetically Modified Organisms |
And 9 more authors.
Transgenic Research | Year: 2015
Numerous genetically modified (GM) crops expressing proteins for insect resistance have been commercialized following extensive testing demonstrating that the foods obtained from them are as safe as that obtained from their corresponding non-GM varieties. In this paper, we report the outcome of safety studies conducted on a newly developed insect-resistant GM rice expressing the cry2A* gene by a subchronic oral toxicity study on rats. GM rice and non-GM rice were incorporated into the diet at levels of 30, 50, and 70 % (w/w), No treatment-related adverse or toxic effects were observed based on an examination of the daily clinical signs, body weight, food consumption, hematology, serum biochemistry, and organ weight or based on gross and histopathological examination. These results demonstrate that the GM rice with cry2A* gene is as safe for food as conventional non-GM rice. © 2015 Springer International Publishing Switzerland