Cornejo-Juarez P.,Instituto Nacional Of Cancerologia Incan |
Volkow-Fernandez P.,Instituto Nacional Of Cancerologia Incan |
Silva-Sanchez J.,Instituto Nacional Of Salud Publica Insp |
Barrios-Camacho H.,Instituto Nacional Of Salud Publica Insp |
And 3 more authors.
Supportive Care in Cancer | Year: 2016
Purpose: The purpose of this study is to evaluate the impact of fecal extended-spectrum β-lactamase-producing Escherichia coli (ESBL-EC) colonization for bloodstream infection (BSI), clinical outcome, and costs in patients with hematologic malignancies (HM) and severe neutropenia. Methods: This is a cohort study, carried out at a cancer-referral hospital. The study population comprises patients with HM, hospitalized prior to administration of the first chemotherapy cycle. A stool culture was taken during the first 48 h; they were grouped as colonized by ESBL-EC or non-ESBL-EC. Patients were followed upon completion of chemotherapy or death. The sum of the days of antibiotics and the length of stay of all hospitalizations in the different cycles of chemotherapy were recorded. Results: We included 126 patients with a recent diagnosis of HM, grouped as 63 patients colonized by ESBL-EC and 63 colonized by non-ESBL-EC, aged 42 ± 16 years old, 78 males (62 %). BSI by ESBL-EC developed in 14 patients (22.2 %) colonized by the same strain and in 5 (7.9 %) in the group colonized with non-ESBL-EC. BSI by non-ESBL-EC was observed in 3 patients (4.7 %) colonized by ESBL-EC and in 17 (26.9 %) patients colonized by non-ESBL-EC. Colonization with ESBL-EC increased the risk of BSI by the same strain (relative risk (RR) = 3.4, 95 % confidence interval (95 % CI) 1.5–7.8, p = 0.001), shorter time to death (74 ± 62 vs. 95 ± 83 days, p < 0.001), longer hospital stay (64 ± 39 vs. 48 ± 32 days, p = 0.01), and higher infection-related costs ($6528 ± $4348 vs. $4722 ± $3173, p = 0.01). There was no difference in overall mortality between both groups. Conclusions: Fecal colonization by ESBL-EC is associated with increased risk of BSI by this strain, longer hospital stay, and higher related costs. © 2015, Springer-Verlag Berlin Heidelberg.
Diaz-Ortega J.L.,University of Santa María in Ecuador |
Bennett J.V.,EUA |
Castaneda D.,INSP |
Martinez D.,SMSCT |
Fernandez de Castro J.,INSP
Vaccine | Year: 2010
Information on antibody persistence after aerosol revaccination with MMR components is limited. Thus, antibody titers were determined in 283 adult participants in a MMR vaccine trial 12 months after revaccination. One group had received aerosolized Triviraten vaccine while two other groups received either injected Triviraten or MMR II vaccine. Both MMR vaccines contained the same rubella strain, but different measles and mumps strains. Seropositivity to measles persisted in 98% of aerosolized vaccine recipients, 92% of injected Triviraten, and 95% of injected MMR II. All participants in the three groups retained seropositivity to rubella, while less than 50% remained seropositive to mumps. © 2010 Elsevier Ltd.
Diaz-Ortega J.L.,University of Santa María in Ecuador |
Bennett J.V.,Centers for Disease Control in Atlanta |
Castaneda D.,INSP |
Vieyra J.-R.,INSP |
And 2 more authors.
Vaccine | Year: 2010
Seroresponses to measles, rubella and mumps were evaluated following the injection of MMR II and injection or aerosol administration of Triviraten in young adults. Response to aerosolized Rubini mumps strain was a focus of interest, given robust responses to aerosolized mumps vaccine (Leningrad-Zagreb strain) in a prior study using aerosolized MMR vaccine. The aerosolized Edmonston-Zagreb (EZ) measles vaccine was significantly more immunogenic than injected EZ vaccine, and comparable to results following injected Moraten measles vaccine having twice the dosage. Responses to rubella were comparable in the three MMR study groups. Aerosolized Rubini vaccine was very highly and unexpectedly less immunogenic than either injected Rubini or Jeryl-Lyn strains. The high attenuation of Rubini vaccine appears to have limited its affinity for respiratory tract receptors, which may underlie its lack of clinical effectiveness. © 2009 Elsevier Ltd. All rights reserved.
Riegler T.,CNRS Poitiers Institute of Chemistry: Materials and Natural Resources |
Allard T.,University Pierre and Marie Curie |
Beaufort D.,CNRS Poitiers Institute of Chemistry: Materials and Natural Resources |
Cantin J.-L.,INSP |
von Bardeleben H.J.,INSP
Physics and Chemistry of Minerals | Year: 2016
High-purity illite specimens from the Mesoproterozoic unconformity-related uranium deposits of Kiggavik, Thelon basin, Nunavut (Canada), and Shea Creek (Athabasca basin, Saskatchewan, Canada) have been studied using electron paramagnetic resonance spectroscopy to determine the thermal stability of the main radiation-induced defects and question the potential of using illite as a natural dosimeter. The observed spectra are complex as they can show in the same region several contributions: (1) an unstable native defect, (2) the main stable defect named Ai by reference to a previous study (Morichon et al. in Phys Chem Minerals 35:339–346, 2008), (3) a signal at g = 2.063 assigned to a new defect, not yet fully characterized, named Ai2 center and (4) impurities such as vanadyl complex or divalent manganese. Isochronal heating shows that the new signal corresponds to a stable species. Isothermal heating experiments at 400 and 450 °C provide values of half-life extrapolated at room temperature and activation energy of 1.9–29,109 years and 1.3–1.4 eV, respectively, corresponding to the Ai center. These parameters allow the use of stable radiation-induced defects as a record of radioactivity down to the Paleoproterozoic period. © 2015, Springer-Verlag Berlin Heidelberg.
Morell N.,ICFO - Institute of Photonic Sciences |
Reserbat-Plantey A.,ICFO - Institute of Photonic Sciences |
Tsioutsios I.,ICFO - Institute of Photonic Sciences |
Schadler K.G.,ICFO - Institute of Photonic Sciences |
And 3 more authors.
Nano Letters | Year: 2016
Suspended monolayer transition metal dichalcogenides (TMD) are membranes that combine ultralow mass and exceptional optical properties, making them intriguing materials for opto-mechanical applications. However, the low measured quality factor of TMD resonators has been a roadblock so far. Here, we report an ultrasensitive optical readout of monolayer TMD resonators that allows us to reveal their mechanical properties at cryogenic temperatures. We find that the quality factor of monolayer WSe2 resonators greatly increases below room temperature, reaching values as high as 1.6 × 104 at liquid nitrogen temperature and 4.7 × 104 at liquid helium temperature. This surpasses the quality factor of monolayer graphene resonators with similar surface areas. Upon cooling the resonator, the resonant frequency increases significantly due to the thermal contraction of the WSe2 lattice. These measurements allow us to experimentally study the thermal expansion coefficient of WSe2 monolayers for the first time. High Q-factors are also found in resonators based on MoS2 and MoSe2 monolayers. The high quality-factor found in this work opens new possibilities for coupling mechanical vibrational states to two-dimensional excitons, valley pseudospins, and single quantum emitters and for quantum opto-mechanical experiments based on the Casimir interaction. © 2016 American Chemical Society.
Martinez-Vega R.A.,National University of Costa Rica |
Danis-Lozano R.,INSP |
Velasco-Hernandez J.,Mexican Institute of Petroleum |
Diaz-Quijano F.A.,Organizacian Latinoamericana Para El Fomento de la Investigacian en Salud OLFIS |
And 5 more authors.
BMC Public Health | Year: 2012
Background: Vector control programs, which have focused mainly on the patient house and peridomestic areas around dengue cases, have not produced the expected impact on transmission. This project will evaluate the assumption that the endemic/epidemic transmission of dengue begins around peridomestic vicinities of the primary cases. Its objective is to assess the relationship between symptomatic dengue case exposure and peridomestic infection incidence. Methods/Design. A prospective cohort study will be conducted (in Tepalcingo and Axochiapan, in the state of Morelos, Mexico), using the state surveillance system for the detection of incident cases. Paired blood specimens will be collected from both the individuals who live with the incident cases and a sample of subjects residing within a 25-meter radius of such cases (exposed cohort), in order to measure dengue-specific antibodies. Other subjects will be selected from areas which have not presented any incident cases within 200 meters, during the two months preceding the sampling (non-exposed cohort). Symptomatic/asymptomatic incident infection will be considered as the dependent variable, exposure to confirmed dengue cases, as the principal variable, and the socio-demographic, environmental and socio-cultural conditions of the subjects, as additional explanatory variables. Discussion. Results indicating a high infection rate among the exposed subjects would justify the application of peridomestic control measures and call for an evaluation of alternate causes for insufficient program impact. On the other hand, a low incidence of peridomestic-infected subjects would support the hypothesis that infection occurs outside the domicile, and would thus explain why the vector control measures applied in the past have exerted such a limited impact on cases incidence rates. The results of the present study may therefore serve to reassess site selection for interventions of this type. © 2012 Martínez-Vega et al; licensee BioMed Central Ltd.
PubMed | INSP, Instituto Nacional Of Salud Publica Insp and Instituto Nacional Of Cancerologia Incan
Type: Journal Article | Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer | Year: 2015
The purpose of this study is to evaluate the impact of fecal extended-spectrum -lactamase-producing Escherichia coli (ESBL-EC) colonization for bloodstream infection (BSI), clinical outcome, and costs in patients with hematologic malignancies (HM) and severe neutropenia.This is a cohort study, carried out at a cancer-referral hospital. The study population comprises patients with HM, hospitalized prior to administration of the first chemotherapy cycle. A stool culture was taken during the first 48 h; they were grouped as colonized by ESBL-EC or non-ESBL-EC. Patients were followed upon completion of chemotherapy or death. The sum of the days of antibiotics and the length of stay of all hospitalizations in the different cycles of chemotherapy were recorded.We included 126 patients with a recent diagnosis of HM, grouped as 63 patients colonized by ESBL-EC and 63 colonized by non-ESBL-EC, aged 4216 years old, 78 males (62%). BSI by ESBL-EC developed in 14 patients (22.2%) colonized by the same strain and in 5 (7.9%) in the group colonized with non-ESBL-EC. BSI by non-ESBL-EC was observed in 3 patients (4.7%) colonized by ESBL-EC and in 17 (26.9%) patients colonized by non-ESBL-EC. Colonization with ESBL-EC increased the risk of BSI by the same strain (relative risk (RR)=3.4, 95% confidence interval (95% CI) 1.5-7.8, p=0.001), shorter time to death (7462 vs. 9583 days, p<0.001), longer hospital stay (6439 vs. 4832 days, p=0.01), and higher infection-related costs ($6528$4348 vs. $4722$3173, p=0.01). There was no difference in overall mortality between both groups.Fecal colonization by ESBL-EC is associated with increased risk of BSI by this strain, longer hospital stay, and higher related costs.
News Article | November 10, 2016
INSP Films has finalized casting on its newest film, County Line, a crime drama currently being filmed in Toccoa, Georgia. The announcement was made by Gary Wheeler, Vice President of Original Movies at INSP Films. County Line tells the story of Alden Rockwell, an aging ex-sheriff dealing with the recent death of his wife and forced into retirement after losing a re-election bid. When his old war buddy, closest friend and neighboring sheriff, Clint Thorne, is critically shot, Rockwell finds himself in the middle of a non-sanctioned investigation. Amidst a dangerous threat to his own life, Rockwell refuses to stand by while a ruthless element takes over the town. Cast in the leading role as Alden Rockwell is Tom Wopat (The Dukes of Hazzard, Longmire, Django Unchained). Sheriff Clint Thorne will be played by Jeff Fahey (Texas Rising, Justified, Lost, Under the Dome). The movie also features Patricia Richardson, (Home Improvement, The West Wing) who plays the spunky diner owner, Maddie Hall. “Audiences who enjoyed Tom Wopat in Longmire and Jeff Fahey in Texas Rising will thoroughly enjoy County Line”, said Wheeler. It embodies all of the elements of a great crime drama, including a surprising and unexpected ending.” County Line is produced by INSP Films and will be distributed by Imagicomm Entertainment. The movie is scheduled for release in late summer or early fall of 2017. About INSP Films INSP Films is a theatrical motion picture production company owned by television network INSP. Founded in 2015, it produces films that are dramatic, inspiring and family-friendly.
News Article | November 29, 2016
INSP has ordered 9 episodes of The Cowboy Way: Alabama, a new original docuseries scheduled to debut on the family entertainment network in August 2017. The announcement comes from Craig Miller, VP of Original Programming at INSP. The Cowboy Way: Alabama follows the adventures of three modern-day cowboys: Bubba Thompson, an industrious rancher and carpenter; Cody Harris, a celebrated rodeo champion and cattle dealer; and Chris "Booger" Brown, an expert cattleman and gifted horse trainer. Much like the cowboys of the Old West, these friends live and ride according to a timeless cowboy code as they build their cattle business in southern Alabama. The long days and exhausting work leave little time for personal lives, but this entertaining and engaging series explores the manner in which they balance the challenges of life on the open range with the demands of raising a family. “In today’s fast-paced, high-tech world, it is fascinating when a group of young men reject present comforts in favor of an authentic cowboy way of life,” said Miller. “We are confident our viewers, who have demonstrated a real passion for stories about cowboys, will embrace Bubba, Cody, and Booger, as these guys are the real deal.” The Cowboy Way: Alabama is produced for INSP by Glassman Media. Andrew Glassman is the executive producer. About INSP INSP is available nationwide to more than 83M households via Dish Network (channel 259), DirecTV (channel 364), Verizon FiOS (channel 286), AT&T U-verse (channel 564) and more than 2,800 cable systems. Click here to find INSP in your area. For quality dramas, positive entertainment and inspiring stories, celebrating the American spirit and honoring timeless traditional values, it’s INSP. About Glassman Media Glassman Media is an independent Los Angeles-based international television production company whose credits include NBC’s upcoming game show The Wall, produced in partnership with Lebron James and his production company Spring Hill Entertainment; four seasons of CMT’s record-setting series, Sweet Home Alabama; four seasons of the NBC hit dating series Average Joe; the critically-acclaimed Three Wishes (NBC), which was named the “most family friendly show on broadcast television.” Adaptations of Glassman Media original formats have been done in territories around the world.
News Article | February 28, 2017
New Episodes of the Award-Winning Culinary Travel Series, Hosted by Entertainer Taylor Hicks, to Premiere This Summer Family-entertainment network INSP has released its destinations for season 2 of State Plate, its award-winning culinary travel series hosted by platinum-selling entertainer and former American Idol™ winner Taylor Hicks. “After much contemplation and deliberation, which included looking at viewer emails, calls and countless social media posts, we have determined we will feature the below states in this next season,” said Doug Butts, Senior Vice President of Programming at INSP: In the new season, Taylor Hicks will once again embark upon a captivating tour to assemble a plate of that state’s most emblematic foods. Along the way, he will visit farms, ranches, markets, festivals and other diverse locales in order to uncover the stories and legends behind their unique food traditions. “It’s been very exciting to see and hear comments from our viewers, especially from those who have lobbied hard to have their own state’s culinary heritage featured,” continued Butts. "With so much great food and history to explore, narrowing the list down to 12 was difficult, but we are confident that what we have selected will offer up a heaping helping of unique cuisine that is both rich in history and flavor.” RIVR Media continues as producer of State Plate and they plan to begin shooting new episodes this spring. The series is scheduled to premiere on INSP in late summer 2017. About INSP INSP is available nationwide to more than 81M households via Dish Network (channel 259), DirecTV (channel 364), Verizon FiOS (channel 286), AT&T U-verse (channel 564) and more than 2,800 cable systems. Click here to find INSP in your area. For quality dramas, positive entertainment and inspiring stories, celebrating the American spirit and honoring timeless values, it’s INSP. About RIVR Media RIVR Media is an American-based TV production company, specializing in reality, documentary and digital programming. RIVR has produced over 2000 shows for 21 cable networks including such series as Renovation Realities, Escaping Polygamy, Trading Spaces, Whale Wars, and Fat Guys in the Woods, to name a few. About Taylor Hicks Taylor Hicks is one of the most beloved and popular American Idol winners of all time. From the start, Hicks’ material on the mega-hit show set him apart, with a unique take on Country, Southern Soul, R&B and Blues. Sixty-four million votes were cast and nearly 37 million American viewers and more than 200 million viewers worldwide tuned in to crown Hicks the Season 5 winner of American Idol, making it one of the most-watched TV events of the last decade. Hicks’ star continued to rise after he stepped off the Idol stage. Less than three weeks after his Idol victory, his debut single, “Do I Make You Proud,” entered at No. 1 on Billboard’s Hot 100, Pop 100, and Single Sales Charts. His self-titled album (Arista), debuted at No. 2 on the Billboard 200 and was quickly certified RIAA Platinum. Hicks is the first male Idol winner to be featured on a Grammy Award-winning album, Jimmy Fallon’s “Blow Your Pants Off,” which took home the 2013 Grammy for Best Comedy Album. Hicks’ career has included stints on Broadway, a national tour with a hit musical, as well as headlining Paris, Las Vegas and other Caesars Entertainment properties all over the United States. In 2017, Taylor will release a new single and album; and will go on a nationwide tour.