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Dallas, TX, United States

InSightec Ltd. , founded in 1999, is a privately held company owned by Elbit Medical Imaging, GE Healthcare, private investors and employees. InSightec was founded specifically to develop MR guided Focused Ultrasound technology. Headquartered in Tirat Carmel near Haifa, Israel, with US headquarters in Dallas Texas, the company has over 160 employees. Wikipedia.


Gerold B.,University of Dundee | Rachmilevitch I.,InSightec | Prentice P.,University of Dundee
New Journal of Physics | Year: 2013

The acoustic emissions from single cavitation clouds at an early stage of development in 0.521 MHz focused ultrasound of varying intensity, are detected and directly correlated to high-speed microscopic observations, recorded at 1 × 106 frames per second. At lower intensities, a stable regime of cloud response is identified whereby bubble-ensembles exhibit oscillations at half the driving frequency, which is also detected in the acoustic emission spectra. Higher intensities generate clouds that develop more rapidly, with increased nonlinearity evidenced by a bifurcation in the frequency of ensemble response, and in the acoustic emissions. A single bubble oscillation model is subject to equivalent ultrasound conditions and fitted to features in the hydrophone and high-speed spectral data, allowing an effective quiescent radius to be inferred for the clouds that evolve at each intensity. The approach indicates that the acoustic emissions originate from the ensemble dynamics and that the cloud acts as a single bubble of equivalent radius in terms of the scattered field. Jetting from component cavities on the periphery of clouds is regularly observed at higher intensities. The results may be of relevance for monitoring and controlling cavitation in therapeutic applications of focused ultrasound, where the phenomenon has the potential to mediate drug delivery from vasculature. © IOP Publishing and Deutsche Physikalische Gesellschaft. Source


Medical guidance systems often employ several data sources using different coordinate systems. In order to map positions from one coordinate system to the other, these guidance systems usually employ rigid-body point-based registration, using pairs of fiducial points: pairs which describe the same physical positions, but in different coordinate systems. The customary test for the quality of the registration is the fiducial registration error (FRE), which is the root-mean-square of the mismatch between the fiducials in each pair (after the registration). The FRE, however, does not give an answer to the question which is usually of interest, and that is the accuracy at a " target" point which is not part of the set of fiducial points.The statistics of the target registration error (TRE) have been studied before and approximate expressions were derived, but those expressions require as input the unknown true fiducial positions. In the present paper, it is proven that by replacing these unknowable true positions with the known measured positions in the expression for mean-square TRE, a higher order approximation is achieved. In other words, it is shown that more accurate estimates are obtained by using less accurate, but available, inputs. Furthermore, in previous approximations FRE and TRE were shown to be statistically independent, whereas here, due to the higher approximation level, it is shown that a slight dependence exists. Thus, the knowledge of FRE can in fact be employed to improve predictions of the TRE statistics. These results are supported by simulations and hold even for fiducial localization error (FLE) distributions with large standard deviations. © 2011 Elsevier B.V. Source


Demore C.E.M.,University of Dundee | Yang Z.,University of Dundee | Volovick A.,University of Dundee | Volovick A.,InSightec | And 3 more authors.
Physical Review Letters | Year: 2012

We measure, in a single experiment, both the radiation pressure and the torque due to a wide variety of propagating acoustic vortex beams. The results validate, for the first time directly, the theoretically predicted ratio of the orbital angular momentum to linear momentum in a propagating beam. We experimentally determine this ratio using simultaneous measurements of both the levitation force and the torque on an acoustic absorber exerted by a broad range of helical ultrasonic beams produced by a 1000-element matrix transducer array. In general, beams with helical phase fronts have been shown to contain orbital angular momentum as the result of the azimuthal component of the Poynting vector around the propagation axis. Theory predicts that for both optical and acoustic helical beams the ratio of the angular momentum current of the beam to the power should be given by the ratio of the beam's topological charge to its angular frequency. This direct experimental observation that the ratio of the torque to power does convincingly match the expected value (given by the topological charge to angular frequency ratio of the beam) is a fundamental result. © 2012 American Physical Society. Source


Patent
InSightec | Date: 2014-01-29

A focused-ultrasound or other procedure for treating a target within a tissue region can be planned iteratively by creating a treatment plan specifying a treatment location pattern and stimuli applied thereto, simulating the treatment, computationally predicting an effect of the simulated treatment, comparing the predicted effect against one or more treatment constraints (such as efficacy and/or safety thresholds), and, if a constraint is violated, repeating the simulation for an adjusted treatment plan.


During a focused-ultrasound or other non-invasive treatment procedure, the motion of the treatment target or other object(s) of interest can be tracked in real time based on the comparison of treatment images against a reference library of images that have been acquired prior to treatment for the anticipated range of motion and have been processed to identify the location of the target or other object(s) therein.

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