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Cambridge, United Kingdom

Burgess I.F.,Insect Research and Development Ltd
Medical and Veterinary Entomology | Year: 2010

Eggs of the head louse, Pediculus capitis De Geer (Phthiraptera: Pediculidae), are difficult to remove because the female louse fixes them to hairs using a proteinaceous secretion that hardens within seconds. The persistent eggshells are harmless but unsightly and are often mistaken for an active infestation. Combing with a fine comb (nit comb) does not readily remove the eggs or empty eggshells because of the resilience of the fixative and both folk remedies and medical products have claimed to facilitate their removal. Measurement of the force required to initiate sliding of the egg fixative using a slip-peel tester was unable to detect evidence that any of three products which claimed to have egg-loosening properties (Step 2™ Nit Removal System, Clear® Lice Egg Remover, RID® Lice Egg Loosener Gel) had any activity or exerted any effect on the egg fixative beyond the lubricating effects conveyed by water or conventional hair conditioner. © 2010 The Author. Journal compilation © 2010 The Royal Entomological Society.

Burgess I.F.,Insect Research and Development Ltd
Medical and Veterinary Entomology | Year: 2014

There are no rigorous data on how long eggs of the head louse, Pediculus capitis (Phthiraptera: Pediculidae), take to hatch. Pediculicide users often report re-infestations after apparently successful treatments in the absence of infective contacts. This study aimed to resolve the question of whether some louse eggs hatch after the completion of treatment, thereby giving rise to a new infestation. Data were extracted from the records of lice collected after treatments in 20 clinical intervention trials. All datasets were eliminated except those in which only newly hatched louse nymphs were found prior to the final assessment. This excluded the possibility that new eggs were laid after the first treatment and thus any young lice found must have originated from eggs laid before the start of treatment. This identified 23 of 1895 (1.2%) records with evidence of louse nymphs emerging at 13 days or more after the first treatment, 3-6 days longer than previous estimates. Current treatment regimens for pediculicides of two applications 7-10 days apart appear inadequate, which may explain continuing infestation in the community. Therefore, it is suggested that a revised approach using three treatments applied at intervals of 1 week should prevent the survival of any nymphs and their development into a new generation of adults. © 2013 The Royal Entomological Society.

Barker S.C.,University of Queensland | Burgess I.,Insect Research and Development Ltd | Meinking T.L.,International Research Team | Mumcuoglu K.Y.,Hebrew University of Jerusalem
International Journal of Dermatology | Year: 2012

Pediculosis capitis, infestation with head lice, is common in all human societies. Chemical pediculicides are often used to control head louse infestations, particularly in wealthy communities. A significant number of different protocols have been used to test the efficacy and safety of pediculicides in clinical trials; this constrains scientific comparison of the evidence for efficacy of the different pediculicides. Here we recommend protocols for clinical trials of the efficacy and safety of single-, two-, and three-treatment interventions. © 2012 The International Society of Dermatology.

Burgess I.F.,Insect Research and Development Ltd | Burgess N.A.,Insect Research and Development Ltd
BMC Research Notes | Year: 2011

Background. Dimeticone 4% lotion is an effective and widely accepted treatment for head louse infestation. However, it is a highly mobile fluid that some people find difficult to apply and is mainly left on the hair for 8 hours or overnight. User preference is for a more manageable and viscous product that can be used with a short application time. Findings. This proof of concept study in 41 people investigated dimeticone 4% liquid gel, a product that is easier to apply than the lotion, applied for 15 minutes on two occasions a week apart. We found that head lice were eliminated from all participants following the first application of product. We did not find lice of any stage on any participant during four post treatment assessments and particularly, unlike other treatments, no young nymphs on days 1 and 6 prior to the second treatment, indicating ovicidal as well as pediculicidal activity. Conclusions. Dimeticone 4% liquid gel has demonstrated efficacy greater than other similar products and the evidence obtained indicates elimination of head louse infestation with a single 15 minute application. Trial registration. Current Controlled Trials ISRCTN59227204. © 2011 Burgess et al; licensee BioMed Central Ltd.

Burgess I.F.,Insect Research and Development Ltd
Tropical Medicine and Health | Year: 2015

The article on use of dimeticone for treatment of epidermal parasitic skin diseases is potentially confusing and misleading because, in a practical sense, only head louse infestation can be treated with this material. Scabies mites are unaffected by silicones and use of dimeticone against other ectoparasites may have unwanted side effects such as anaphylactiform reactions or increased risk of pathogen transmission. © 2015 by The Japanese Society of Tropical Medicine.

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