Rouen, France
Rouen, France

INSA de Rouen is a French grande école, that is to say a five-year curriculum which aims to train engineers who possess humane qualities and are well versed in the primary areas of science and engineering. Located in Saint-Étienne-du-Rouvray, on the Madrillet technology center campus, in the suburbs of Rouen, this school accommodates more than 1400 students who specialize in one of the 7 fields which have been available in Rouen for the 3 last years. Wikipedia.

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Grant
Agency: European Commission | Branch: H2020 | Program: RIA | Phase: MG-1.2-2015 | Award Amount: 6.83M | Year: 2016

For decades, most of the aviation research activities have been focused on the reduction of noise and NOx and CO2 emissions. However, emissions from aircraft gas turbine engines of non-volatile PM, consisting primarily of soot particles, are of international concern today. Despite the lack of knowledge toward soot formation processes and characterization in terms of mass and size, engine manufacturers have now to deal with both gas and particles emissions. Furthermore, heat transfer understanding, that is also influenced by soot radiation, is an important matter for the improvement of the combustors durability, as the key point when dealing with low-emissions combustor architectures is to adjust the air flow split between the injection system and the combustors walls. The SOPRANO initiative consequently aims at providing new elements of knowledge, analysis and improved design tools, opening the way to: Alternative designs of combustion systems for future aircrafts that will enter into service after 2025 capable of simultaneously reducing gaseous pollutants and particles, Improved liner lifetime assessment methods. Therefore, the SOPRANO project will deliver more accurate experimental and numerical methodologies for predicting the soot emissions in academic or semi-technical combustion systems. This will contribute to enhance the comprehension of soot particles formation and their impact on heat transfer through radiation. In parallel, the durability of cooling liner materials, related to the walls air flow rate, will be addressed by heat transfer measurements and predictions. Finally, the expected contribution of SOPRANO is to apply these developments in order to determine the main promising concepts, in the framework of current low-NOx technologies, able to control the emitted soot particles in terms of mass and size over a large range of operating conditions without compromising combustors liner durability and performance toward NOx emissions.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.1.1-3. | Award Amount: 7.41M | Year: 2011

The environmental benefits of low emissions lean burn technology in reducing NOx emissions up to 80% will only be effective when these are deployed to a large range of new aero-engine applications. While integrating and developing low emission combustion design rules, IMPACT-AE will deliver novel combustor design methodologies for advanced engine architectures and thermodynamic cycles. It will support European engine manufacturers to pick up and keep pace with the US competitors, being already able to exploit their new low emission combustion technology to various engine applications with short turn-around times. Key element of the project will be the development and validation of design methods for low emissions combustors to reduce NOx and CO emissions by an optimization of the combustor aero-design process. Preliminary combustor design tools will be coupled with advanced parametrisation and automation tools. Improved heat transfer and NOx models will increase the accuracy of the numerical prediction. The advanced representation of low emission combustors and the capability to investigate combustor scaling effects allow an efficient optimisation of future combustors targeting a cut of combustor development time by 50%. IMPACT-AE is split into four technical work packages: WP1Development of smart design methodologies for clean combustion as central WP to deliver the new methodology for combustor design, WP2Modelling and design of advanced combustor wall cooling concepts for combustor liner design definition as key technology area, WP3Technology validation by detailed flame diagnostics to substantiate fuel injector design rules implemented into the design methodology and WP4Methodology demonstration for efficient low NOx combustors will validate the combustor design. The consortium consists of all major aero-engine manufactures in Europe, 7 universities and 3 research establishments with recognised experience in low emission combustion research and 10 SMEs.


Grant
Agency: European Commission | Branch: FP7 | Program: CP-FP | Phase: AAT.2010.3.3-2. | Award Amount: 4.24M | Year: 2011

The project aims for the increase of passenger survivability in the case of fire aboard aircraft focused on the next generation of aircraft. The composite materials and other combustible materials are increasingly used in order to reduce the weight of the aircraft or to higher the passenger comfort, but they raise the fire load significantly. Although these materials have passed the certification tests, it is necessary to study and assess fire risks for relevant areas, specific zones of the aircraft and the entire aircraft. Existing and validated simulation tools will be adapted in the project. Today the simulation of fire propagation and evacuation in aeronautics suffers from lacking data of material properties and fire behavior. Relevant data necessary for the proposed advanced simulation as far as not available will be gained by experiments. Beside the provision of physical and chemical data a sound analysis of existing data bases maintained by aviation authority, airline and aircraft manufacturer in order to identify and classify the relevant fire related scenarios for in-flight and post-crash fires will provide the second basis for the improved simulation. The project will analyze the sensing capacities and deployment of the relevant sensors aboard aircraft and make use of advanced sensor data fusion to increase the overall performances. This together with the results of the simulation of fire propagation will allow recommending improvements for the aircraft operation in case of fire related incidents. Together with the result of the advanced evacuation simulation the results of the project will directly influence the design of the next generation of aircraft with respect to fire prevention and fire management. The consortium composed of aircraft manufacturer, aviation authority, research establishments and universities will undertake the necessary efforts to make the gained knowledge available to all relevant parties to achieve the project objectives.


Patent
INSA Rouen, French National Center for Scientific Research, University of Rouen and Vfp Therapies | Date: 2014-01-24

A compound of formula (I) in which the dotted lines indicate the presence of at least one double bond; n=0 to 4; R_(3 )and R_(4 )are H, or when n=1, R_(3 )and R_(4 )can also form together a double bond between the carbon atoms, and m=0, 1 or 2, Z is CH or N or Z is C and CHR_(3) is CH linked by the double bond to cyclopentanone; or ()_(m)- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N heteroaryl; R_(8 )is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR, CN, COR, CF_(3), SOR, SO_(2)R, SONRR, SO_(2)NRR, NO_(2), halogen, heteroaryl; and the pharmaceutical salts and stereisomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimers disease.


Patent
French National Center for Scientific Research, University of Rouen and INSA Rouen | Date: 2013-10-01

This invention relates to 1,2,4-triazine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.


Patent
INSA Rouen, French National Center for Scientific Research, University of Rouen and Vfp Therapies | Date: 2014-07-30

A compound of the formula (I) in which the dotted lines indicate the presence of at least one double bond; n = 0 to 4; R_(3) and R_(4) are H, or when n = 1, R_(3) and R_(4) can also form together a double bond between the carbon atoms, and m = 0, 1 or 2, Z is CH or N or Z is C and -CHR_(3)- is =CH- linked by the double bond to the cyclopentanone; or -(-)_(m)- is absent, and Z is NH, >N-alkyl, >N-phenyl, >N-benzyl or >N-heteroaryl; R_(8) is alkyl, aryl or heteroaryl which can be optionally substituted; EWG represents an electron withdrawing group selected from the group comprising COOR, COSR, CONRR, CN, COR, CF_(3), SOR, SO_(2)R, SONRR, SO_(2)NRR, NO_(2), halogen, heteroaryl; and the pharmaceutical salts or tautomers thereof. The compounds of formula (I) are potent in the treatment of neurodegenerative diseases such as Alzheimers disease.


Harrison-Marchand A.,INSA Rouen | Mongin F.,CNRS Chemistry Institute of Rennes
Chemical Reviews | Year: 2013

Organometallic chemistry is one of the key assets to successfully achieve complex organic transformations. Numerous tools have been conceived and developed to address problems related to the chemo-, regio-, and stereoselectivities of general reactions such as the deprotonation of prochiral species or the creation of C-C bonds. By way of announcement of the concept, it was decided to dedicate this preliminary review (part 1) on the structural knowledge, in the solid state and/or in solution, of oligo-, homo-, and heteroMAAs that are made of lithium, sodium, and potassium species, as well as magnesium, aluminum, and zinc derivatives. With the latter selection covering still a large panel of organo(bi)metallic combinations depicted in the literature, only systems that are the most encountered and discussed by organic chemists and that are either obtained directly by mixing two commercial organometallics routinely used in organic chemistry or very frequently synthesized and easy to access will be depicted.


Mongin F.,CNRS Chemistry Institute of Rennes | Harrison-Marchand A.,INSA Rouen
Chemical Reviews | Year: 2013

The article presents generalities concerning the formation and main features of the Mixed AggregAtes (MAA). Alternative ways to metal organo, amido, and/or alkoxo ate compounds, such as magnesates, calciates, manganates, ferrates, nickelates, and zincates, use the corresponding monometallic compounds (cocomplexation approach). The syntheses of mixed-ligand organo, amido, and/or alkoxo heteroMAAs are in general performed by mixing precursors possessing different ligands in appropriate ratios. The structural data of these compounds have been summarized. It is important to note that, in the presence of oxygen during the preparation of metal ate compounds such as magnesates, aluminates, manganates, and zincates, complex structures with oxo or peroxo cores can be formed, and some of them were evidenced by X-ray crystallography.


Cahard D.,INSA Rouen | Bizet V.,INSA Rouen
Chemical Society Reviews | Year: 2014

All domains of chemistry are increasingly impacted by organofluorine molecules, often favorably. In asymmetric synthesis of fluorinated compounds, significant achievements are the result of extensive research efforts toward appropriate experimental conditions rather than of the rationalization of fluorine effects. Most of the time, the influence of fluorine is inspected retrospectively. When elaborating a synthetic plan, the question should not be only when and how to introduce fluorine but also how to use the effects of fluorine for a desirable result. The subtle effects of fluorine atom(s) on the course of asymmetric reactions are outlined in this tutorial review. We present some selected examples of asymmetric reactions that involve fluorinated components either as reactants, catalysts, solvents or additives, and a comparative study of the stereochemical outcomes with reactions carried out in the presence of non-fluorinated analogues. © 2014 The Royal Society of Chemistry.


Besset T.,INSA Rouen | Schneider C.,INSA Rouen | Cahard D.,INSA Rouen
Angewandte Chemie - International Edition | Year: 2012

A tri-ing transformation: The increasingly high demand for trifluoromethylated arenes and heteroarenes is a major challenge that has been addressed through the development of trifluoromethylation reactions. Several effective approaches for late-stage trifluoromethylation, as well as the use of practical and cheap trifluoromethylation reagents, are highlighted. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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