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Prakash A.,Inorganic Bioinorganic Research Laboratory | Gangwar M.P.,Mahatma Jyotiba Phule Rohilkhand University | Singh K.K.,S.R.M.S. CET
International Journal of ChemTech Research | Year: 2011

Complexes of nickel(II) of N,N'-disalicylidene-3,4-diaminotoluene(H2L1), N,N'-bis(3,5 di-tertbutylsalicylidene)- 1,3-diaminopropane(H2L2), tetrathiafulvalene-N,N'-phenylene bis (salicylideneimine)(H2L3), ohydroxybenzaldehyde,o-hydroxyacetophenone ethylene diamine (H2L4) and 1-phenylbutane-1,3-dionemono-Smethylisothio- semicarbazone with 5-phenylazo- o-hydroxybenzaldehyde(H2L5) have been synthesized and characterized by elemental analysis, electronic, IR,1H NMR, magnetic susceptibility measurement, molar conductance and thermal studies. The complexes are found to be non- ionic in nature. The analytical studies show tetrahedral, square planar and octahedral geometries of the complexes. The complexes have been found to posses 1:1 (M: L) stoichiometry. The bioefficacy of the ligands and their complexes have been examined against the growth of bacteria in vitro to evaluate their anti-microbial potential.

PubMed | Inorganic & Bioinorganic Research Laboratory
Type: | Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy | Year: 2012

Schiff bases derived from 2-nitrobenzaldehyde with amino acids (glycine, methionine) and their Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by various physico-chemical techniques. From spectral studies, it has been concluded that the ligands acts as bidentate molecule, coordinates metal through azomethine nitrogen and carboxylate oxygen. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML(2) complexes. X-ray powder diffraction helps to determine the cell parameters of the complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a square planar geometry. The ligands and their metal complexes have been tested in vitro against Streptococcus, Staph, Staphylococcus aureus and Escherchia coli bacteria in order to assess their antibacterial potential. The results indicate that the biological activity increases on complexation.

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