Inorganic and Bioinorganic Research Laboratory

Rānīkhet, India

Inorganic and Bioinorganic Research Laboratory

Rānīkhet, India

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Prakash A.,Inorganic and Bioinorganic Research Laboratory | Adhikari D.,Inorganic and Bioinorganic Research Laboratory
International Journal of ChemTech Research | Year: 2011

Schiff bases are versatile ligands which are synthesized from the condensation of an amino compound with carbonyl compounds. These compounds and their metal complexes are very important as catalysts in various biological systems, polymers, dyes and medicinal and pharmaceutical fields. Their use in birth control, food packages and as an O 2 detector is also outlined. This review summarizes the applications of Schiff bases and their complexes.


Singh B.K.,Inorganic and Bioinorganic Research Laboratory | Bhojak N.,Government of Rajasthan | Prakash A.,Inorganic and Bioinorganic Research Laboratory
E-Journal of Chemistry | Year: 2012

Cu (II), Co (II), Ni (II) and Mn (II) complexes of Schiff base derived from 2-aminophenol and pyrrole-2- carbaldehyde have been prepared. The complexes are formed by coordination of N and O atoms of the ligand. Their structures were characterized by physico-chemical and spectroscopic methods. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a tetrahedral/ square planar geometry. The bio-efficacy of the ligand and their complexes has been examined against the growth of bacteria in vitro to evaluate their anti-microbial potential.


Prakash A.,Inorganic and Bioinorganic Research Laboratory | Singh B.K.,Inorganic and Bioinorganic Research Laboratory | Rajour H.K.,University of Delhi | Bhojak N.,Government of Rajasthan
Main Group Metal Chemistry | Year: 2010

Two symmetrical Schiff bases have been prepared by the condensation of ethylenediamine and 4-nitrobenzaldehyde/ acetophenone. These Schiff bases and their inorganic Sn(II) and Pb(II) complexes have been synthesized and characterized by various physico-chemical studies. The spectroscopic data(IR, 1H NMR) indicates coordination of metal ions through azomethine nitrogen and acetate/chloride ions. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a tetrahedral geometry. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the ligands and their complexes has been examined against the growth of bacteria in vitro to evaluate their anti-microbial potential.


Singh B.K.,Inorganic and Bioinorganic Research Laboratory | Prakash A.,Inorganic and Bioinorganic Research Laboratory | Rajour H.K.,University of Delhi | Bhojak N.,MGS University | Adhikari D.,Inorganic and Bioinorganic Research Laboratory
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

A new Schiff base 2-aminophenol-pyrrole-2-carboxaldehyde and its Zn(II), Cd(II), Sn(II) and Pb(II) complexes have been synthesized and characterized by various physicochemical studies. Spectral studies (IR and 1H NMR) indicate deprotonation and coordination of phenolic oxygen along with binding of pyrrole nitrogen, azomethine nitrogen and anion with metal ions. The presence of lattice water molecule(s) has also been confirmed by TG/DTA studies. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the ligand and their complexes has been examined against the growth of bacteria in vitro to evaluate their antimicrobial potential. Molecular structures of the complexes have been optimized by MM2 calculations and suggest a tetrahedral geometry around metal ions. © 2010 Elsevier B.V. All rights reserved.


Prakash A.,Inorganic and Bioinorganic Research Laboratory | Singh B.K.,Inorganic and Bioinorganic Research Laboratory | Bhojak N.,MGS University | Adhikari D.,Inorganic and Bioinorganic Research Laboratory
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2010

The new Schiff bases N,N′-bis (4-nitro benzaldehyde) ethylenediamine (L 1) and N,N′-bis (acetophenone) ethylenediamine (L 2) and its Zn(II), Cd(II) complexes were synthesized and characterized by different physicochemical studies. Vibrational spectra indicate coordination of metal ion through azomethine nitrogen and acetate/nitrate ions. The presence of water molecule in all the complexes has been supported by TG/DTA studies. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bioefficacy of the ligands and their complexes have been examined against the growth of bacteria in vitro to evaluate their antimicrobial potential. The results indicate that the ligand and their metal complexes possess notable antimicrobial properties. X-ray powder diffraction determines the cell parameters of the complexes. © 2010 Elsevier B.V. All rights reserved.


Singh B.K.,Inorganic and Bioinorganic Research Laboratory | Rajour H.K.,University of Delhi | Prakash A.,Inorganic and Bioinorganic Research Laboratory
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy | Year: 2012

Schiff bases derived from 2-nitrobenzaldehyde with amino acids (glycine, methionine) and their Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by various physico-chemical techniques. From spectral studies, it has been concluded that the ligands acts as bidentate molecule, coordinates metal through azomethine nitrogen and carboxylate oxygen. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML 2 complexes. X-ray powder diffraction helps to determine the cell parameters of the complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a square planar geometry. The ligands and their metal complexes have been tested in vitro against Streptococcus, Staph, Staphylococcus aureus and Escherchia coli bacteria in order to assess their antibacterial potential. The results indicate that the biological activity increases on complexation. © 2012 Elsevier B.V. All rights reserved.


Prakash A.,Inorganic and Bioinorganic research Laboratory | Kabir S.,Inorganic and Bioinorganic research Laboratory | Agrawal M.,Bareilly College | Sharma R.,Inorganic and Bioinorganic research Laboratory | Gupta A.K.,Inorganic and Bioinorganic research Laboratory
International Journal of ChemTech Research | Year: 2014

New complexes of Co(II),NI(II) and Cu(II) with Schiff bases obtained by condensation of pyridine- 2-arboxaldehyde and L-Histidine, L-Valine have been synthesized and characterized by various physicochemical techniques. The complexes have been found to posses 1:2(M:L) stoichiometry. The electronic spectral data and magnetic moment measurement suggest octahedral geometry of the complexes. TGA studies showed absence of water molecules in all complexes.

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