Malatya, Turkey
Malatya, Turkey

İnönü University is a public university in Malatya, Turkey. On 28 January 1975 Turkish Parliament ordered the establishment of İnönü University in Malatya, the hometown of the 2nd and 8th presidents of Turkey who are Ismet Inonu and Turgut Ozal.İnönü University is one of the biggest public university of eastern part of Turkey. İnönü University has six campuses, five institutes, thirteen faculties, nineteen research centers and an innovative science and technology park which is called Malatya Technology Development Zone in Malatya. Over 70,000 students have graduated since 1975 from İnönü University. Inside the university, there is a museum commemorating Ismet Inonu, along-with another museum commemorating Turgut Ozal.İnönü University Turgut Ozal Medical Center is one of the biggest research and implementation hospital in the world. It serves as a district hospital and accepts patients from neighbor countries as well. It is among the top three hospitals in liver transplant in the world and also serves in other areas such as kidney transplants, bone marrow transplants and burn injuries. Turgut Ozal Medical Center has Faculty of Medicine, Faculty of Dentistry and Faculty of Pharmacy and also, it has an Adult Hospital and a Liver Transplant Hospital. İnönü University has planned to have Oncology Hospital until 2018. Wikipedia.

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Major advances in antiepileptic drug therapy have taken place since 1950s. In the first period, several antiepileptic drugs (AEDs) such as phenobarbital, diphenylhydantoin, ethosuximide, carbamazepine, benzodiazepines and valproic acid were introduced to epilepsy treatment. After 1990 many new generation drugs (lamotrigine, topiramate, gabapentine, pregabaline, felbamate, lacosamide, levetiracetam etc.) have been developed. These novel AEDs have offered some advantages such as fewer side effects, fewer drug-drug interactions, and better pharmacokinetic properties. But pharmacoresistance and therapeutic failure in 20-25% of the patients remain the main reasons to continue efforts to find safer and more efficacious drugs and ultimate a treatment for this devastating disease. Several AEDs especially novel compounds have been found to be effective also in the treatment of several other neurologic and psychiatric disorders. Chemical diversity of the newer antiepileptic drugs as well as those currently in clinical development is another point that encourages medicinal chemists to study this subject. This review summarizes recent studies on the development of potential anticonvulsant compounds in different chemical structures, their structure-activity relationships and also therapeutic usages of AEDs other than epilepsy. © 2012 Bentham Science Publishers.


Grant
Agency: European Commission | Branch: FP7 | Program: MC-IRSES | Phase: FP7-PEOPLE-2009-IRSES | Award Amount: 223.20K | Year: 2011

The STONE project addresses scientific issues related to stone fruit (Prunus species) biodiversity. In a worldwide competitive context, stone fruit breeding programmes have to face new challenges regarding the maintenance of high quality fruit production under a changing climatic environment and increasing threats from pathogens, especially the sharka disease. STONE is a four years coordinated joint programme of staff exchange for short and medium periods between two European organisations, an associated and two ICPC third countries. The IRSES scheme is designed to provide opportunities of mobility to researchers and support research organisations. It integrates existing bilateral collaborative activities into a coherent long-term multinational programme addressing a key issue to two high priorities on the political agenda of the EU, i.e sustainable agricultural fruit production and biodiversity. The programme of exchange is intended to develop common tools and to jointly use these tools for the comparison of the genetic biodiversity in the European, Caucasian and Central Asian Apricot, Peach and Cherry germplasms. The project objectives include the assessment of the genetic diversity at selected loci directly affecting response to virus infection and to climate changes. The range of common fruit tree species of interest and of climatic conditions, as well as the strategic importance of fresh fruit production in all the countries involved will provide a coherent framework and socio-economic background for the planned research activities. Three topics have been identified as most relevant for all partners involved in the STONE project: assessment of the broad genetic diversity at the centers of origin and along the expansion routes of Prunus species after domestication and analysis of the genetic variability at loci related to Plum pox virus resistance and at loci controlling winter chilling-dependent floral induction.


Akbulut S.,Inonu University
World Journal of Gastroenterology | Year: 2015

AIM: To review the literature on idiopathic sclerosing encapsulating peritonitis (SEP), also known as abdominal cocoon syndrome. METHODS: The PubMed, MEDLINE, Google Scholar, and Google databases were searched using specific key words to identify articles related to idiopathic SEP. These key words were "sclerosing encapsulating peritonitis," "idiopathic sclerosing encapsulating peritonitis," "abdominal cocoon," and "abdominal cocoon syndrome." The search included letters to the editor, case reports, review articles, original articles, and meeting presentations published in the English-language literature from January 2000 to May 2014. Articles or abstracts containing adequate information about age, sex, symptom duration, initial diagnosis, radiological tools, and surgical approaches were included in the study. Papers with missing or inadequate data were excluded. RESULTS: The literature search yielded 73 articles on idiopathic (primary) SEP published in 23 countries. The four countries that published the greatest number of articles were India (n = 21), Turkey (n = 14), China (n = 8) and Nigeria (n = 3). The four countries that reported the greatest number of cases were China (n = 104; 53.88%), India (n = 35; 18.13%), Turkey (n = 17; 8.80%) and Nigeria (n = 5; 2.59%). The present study included 193 patients. Data on age could be obtained for 184 patients (range: 7-87 years; mean ± SD, 34.7 ± 19.2 years), but were unavailable for nine patients. Of the 184 patients, 122 were male and 62 were female; sex data could not be accessed in the remaining nine patients. Of the 149 patients whose preoperative diagnosis information could be obtained, 65 (43.6%) underwent operations for abdominal cocoon, while the majority of the remaining patients underwent operations for a presumed diagnosis of intestinal obstruction and/or abdominal mass. Management information could be retrieved for 115 patients. Of these, 68 underwent excision + adhesiolysis (one laparoscopic); 24 underwent prophylactic appendectomy in addition to excision + adhesiolysis. Twenty patients underwent various resection and repair techniques along with excision + adhesiolysis. The remaining three patients were managed with antituberculosis therapy (n = 2) and immunosuppressive therapy (n = 1). CONCLUSION: Idiopathic SEP is a rare disorder characterized by frequently recurring bouts of intestinal obstruction. Surgical therapy is the gold standard management strategy.. © 2015 Baishideng Publishing Group Inc. All rights reserved.


Sarimeseli A.,Inonu University
Energy Conversion and Management | Year: 2011

Effect of microwave power output on effective moisture diffusivity, colour parameters and rehydration characteristics of coriander leaves (Coriandrum sativum L.) was investigated by using a microwave drier. Within the range of microwave power values, 180-360 W, effective moisture diffusivities were found to be 6.3 × 10-11-2.19 × 10-10 m2/s and the result could successfully be presented with the model suggested by Midilli et al. No significant differences in the colour parameters were obtained between the fresh and dried samples and the changes in their values were not dependent on the power outputs of the microwave drier. The highest rehydration capacity was recorded for the samples dried at 180 W and lowest at 900 W. © 2010 Elsevier Ltd. All rights reserved.


Karakoc M.B.,Inonu University
Construction and Building Materials | Year: 2013

In this study, the residual compressive strength of concrete with expanded perlite aggregate (EPA) and pumice aggregate (PA) after it was exposed 700 °C and then cooled in three cooling regimes (natural, water and furnace cooling) at w/b ratio for 0.25, 0.30, 0.35 was investigated. EPA and PA replacements of fine aggregate were used 10%, 20%, and 30%. Test results showed that the compressive strength of concrete cooled in water cooling after being exposed to the effect of different mixture with EPA and PA is higher than that cooled in natural and furnace. Based on the test results, the compressive strength of concrete cooled in water, furnace and natural cooling decreased by an average of 78%, 81% and 83%, respectively, when compared to control samples. © 2012 Elsevier Ltd. All rights reserved.


Water samples were collected at monthly intervals during 1. year of monitoring from Kralkizi, Dicle and Batman dam reservoirs in the Tigris River basin to assess the concentrations of dissolved heavy metals and to determine their spatial and seasonal variations. The results indicated that dissolved heavy metal concentrations in the reservoirs were very low, reflecting the natural background levels. The lowest total metal concentrations in the three dam reservoirs were detected at sampling sites close to the dam wall. However, the highest total concentrations were observed at sites, which are located at the entrance of the streams to the reservoirs. Fe, Cr and Ni were the most abundant elements in the reservoirs, whereas Cd and As were the less abundant. The mean concentrations of dissolved metals in the dam reservoirs never exceeded the maximum permitted concentrations established by EC (European Community), WHO and USEPA drinking water quality guidelines. All heavy metals showed significant seasonal variations. As, Cd, Cr, Cu, Fe, Ni and Pb displayed higher values in the dry season, while higher values for Zn in the wet season. Cluster analysis grouped all ten sampling sites into three clusters. Clusters 1 and 2, and cluster 3 corresponded to relatively low polluted and moderate polluted regions, respectively. PCA/FA demonstrated the dissolved metals in the dam reservoirs controlled by natural sources. © 2013 Elsevier Ltd.


In this study, ThF4, UF4 and UO2 heavy metals were used with ratios of 2% and 10% while Flibe (Li2BeF 4) molten salt mixture and 100% Flibe were used as fluids in the liquid first wall, liquid second wall and shield zones of the APEX. The steel wall that is used as a structural material is 4 cm in thickness and calculations for each 0.5 cm thick zone of the steel wall were performed. In this study, the total changes caused by radiation damage in the steel used as a structural material for 20 cm, 30 cm, 40 cm and 50 cm thicknesses of liquid second wall, for each 0.5 cm thick zones of the steel wall and for the selected fluid rates were investigated for 30 full power years (FPY). The neutron wall load is assumed to be 10 MW/m2. Three-dimensional nucleonic calculations were performed using MCNPX-2.5.0 Monte Carlo code and ENDF/B-VI nuclear data library. © Published by Elsevier Ltd.


Altintas R.,Inonu University
Journal of endourology / Endourological Society | Year: 2013

This experimental study was designed to explore the protective effect of apocynin, the NADPH-oxidase inhibitor, on kidney damage induced by ischemia/reperfusion (I/R) in a rat model. Thirty-two rats were randomly divided into a control group and three I/R groups (1-hour ischemia followed by 23-hour reperfusion). Three I/R groups were treated by apocynin (20 mg/kg, i.p.) at two different time points (before ischemia and during ischemia). The histopathological findings, including apoptotic changes, and also tissue malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathion peroxidase (GPX), reduced glutathione (GSH), myeloperoxidase (MPO), blood urea nitrogen (BUN), and serum creatinine (Cr) levels, were determined. Kidney tissue MDA and MPO, and serum BUN and Cr levels were found to be significantly higher in the I/R group, but there was no statistically significant difference in the levels of SOD, CAT, GPX, and GSH between the I/R and the control groups. Although apocynin significantly reduced MDA and MPO in group 3 and increased GPX in both treatment groups when compared to the I/R group, the elevated BUN and Cr levels were significantly reduced in treatment groups. Renal I/R injury also induced extensive tubular necrosis, glomerular damage, and apoptosis in the histological evaluation. Apocynin, especially when used during ischemia, ameliorated these histological damages in different amounts in treatment groups. The beneficial effects of apocynin on renal I/R injury were evaluated for the first time.


Talu M.F.,Inonu University
Expert Systems with Applications | Year: 2013

A new online region-based active contour model (ORACM) is proposed in this paper. The classical geodesic active contour (GAC) model has only local segmentation property, although the Chan-Vese (C-V) model possesses global. An up-to-date active contour model (ACM with SBGFRLS) proposed in Zhang, Zhang, Song, and Zhou (2010) both has the properties of global/local segmentation and incorporates the GAC and the C-V models to raise active contours' performance on image segmentation. However it has two major disadvantages. First, it deforms the active contour model just using the gradient of current level set iteratively and so works too slowly. Second, it needs a parameter α which plays major impact on the results and to be tuned according to input images. The proposed model ORACM eliminates these two disadvantages by using a new binary level set formula and a new regularization operation such as morphological opening and closing. Without changing segmentation accuracy, ORACM requires no parameter and less time over the traditional ACMs. Experiments on synthetic and real images demonstrate that the computational cost of ORACM with the morphological operations is 3.75 times less than the traditional ACMs on average. © 2013 Elsevier B.V. All rights reserved.


Butter oil triacylglycerols (BO-TAGs), free of antioxidants, including β-carotene, were obtained via sequential treatments with activated carbon (AC) adsorption and alumina column chromatography. α-Tocopherol, β-carotene and ascorbyl palmitate (AP) were added to BO-TAGs, individually, or in different combinations. An accelerated oven-oxidation test was carried out at 60°C to determine the most effective dosages of the antioxidants. Among the antioxidants evaluated, α-tocopherol was found to be the most effective, at the concentration of 50 μg/g. To determine the possible synergism between the antioxidants, binary or ternary combinations of α-tocopherol, β-carotene and AP were added to BO-TAGs at concentrations of 50, 5, and 50μg/g, respectively. Ternary combinations of these antioxidants were significantly better in retarding oxidation than were binary blends of α-tocopherol with β-carotene or AP. However, a prooxidant effect was observed, especially when β-carotene and AP were used individually or in binary combination. © 2010 Elsevier Ltd.

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