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Bharathimohan K.,Bharathidasan University | Bharathimohan K.,Orchid Chemicals and Pharmaceuticals Ltd | Ponpandian T.,Inogent Laboratories Pvt Ltd | Ahamed A.J.,Bharathidasan University | Bhuvanesh N.,Texas A&M University
Beilstein Journal of Organic Chemistry | Year: 2014

Herein, we describe a one-pot protocol for the synthesis of a novel series of polycyclic triazole derivatives. Transition metalcatalyzed decarboxylative CuAAC and dehydrogenative cross coupling reactions are combined in a single flask and achieved good yields of the respective triazoles (up to 97% yield). This methodology is more convenient to produce the complex polycyclic molecules in a simple way. © 2014 Bharathimohan et al; licensee Beilstein-Institut. Source

Tammana R.,Inogent Laboratories Pvt Ltd | Tammana R.,Jawaharlal Nehru Technological University | Vemula K.K.,Inogent Laboratories Pvt Ltd | Guruvindapalli R.,Inogent Laboratories Pvt Ltd | And 3 more authors.
Arkivoc | Year: 2012

A short, concise and efficient synthesis of Linezolid was accomplished through a convergent scheme utilizing either (S)-1-azido-3-chloropropan-2-yl chloroformate or (S)-1- phthalimido-3- chloropropan-2-yl chloroformate as a key starting material. The synthesis demonstrates utility of (S)-1-azido-3- chloropropan-2-yl chloroformate and/or (S)-1-phthalimido-3-chloropropan-2-yl chloroformate to facilitate the expeditious construction of 3-aryl-5- (substituted methyl)-2- oxazolidinones and offers the possibility of accessing related 2-oxazolidinone members easily as well as making additional analogues of Linezolid. © ARKAT-USA, Inc. Source

Madhusudhan G.,Inogent Laboratories Pvt Ltd | Reddy M.S.,Inogent Laboratories Pvt Ltd | Reddy Y.N.,Inogent Laboratories Pvt Ltd | Vijayalakshmi V.,Inogent Laboratories Pvt Ltd | And 2 more authors.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2010

A facile, efficient and convenient method has been developed for the one-pot synthesis of 2-oxazolidinones from the corresponding 1, 2-azido alcohols via phosphazene and isocyanate intermediates in presence of Ph 3P/CO2 in toluene. Source

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