Innovative Targeting Group

Rotterdam, Netherlands

Innovative Targeting Group

Rotterdam, Netherlands

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Dicheva B.M.,Innovative Targeting Group | Hagen T.L.M.T.,Innovative Targeting Group | Li L.,Innovative Targeting Group | Schipper D.,Innovative Targeting Group | And 8 more authors.
Nano Letters | Year: 2013

Developing selectively targeted and heat-responsive nanocarriers holds paramount promises in chemotherapy. We show that this can be achieved by designing liposomes combining cationic charged and thermosensitive lipids in the bilayer. We demonstrated, using flow cytometry, live cell imaging, and intravital optical imaging, that cationic thermosensitive liposomes specifically target angiogenic endothelial and tumor cells. Application of mild hyperthermia led to a rapid content release extra- and intracellularly in two crucial cell types in a solid tumor. © 2012 American Chemical Society.

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