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Costa L.M.M.,Rua Santa Adelia | De Olyveira G.M.,Rua Santa Adelia | Basmaji P.,Innovatecs Biotechnology Research and Development | Filho L.X.,Natural Products Laboratory and Biotechnology
Journal of Bionanoscience | Year: 2011

Nanobiocellulose has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavours, especially for medical devices. In fact, biomedical devices recently have gained a significant amount of attention because of an increased interest in tissueengineered products for both wound care and the regeneration of damaged or diseased organs. Due to its unique nanostructure and properties, microbial cellulose is a natural candidate for numerous medical and tissue-engineered applications. The architecture of nanobiocellulose materials can be engineered over length scales ranging from nano to macro by controlling the biofabrication process. In this work, bacterial cellulose biocomposites were obtained by change fermentation medium with sugar cane, honey and dates paste (Dibs). SEM and AFM images showed differents surface morphology. FTIR analysis found some interactions between these additives. DSC and TGA showed higher thermal properties and change crystallinity of the developed bionanocomposite. Copyright © 2011 American Scientific Publishers.


Basmaji P.,Innovatecs Biotechnology Research and Development | de Olyveira G.M.,Sao Paulo State University | dos Santos M.L.,Sao Paulo State University | Guastaldi A.C.,Sao Paulo State University
Journal of Biomaterials and Tissue Engineering | Year: 2014

Bacterial cellulose is a highly hydrated pellicle made up of a random assembly of ribbon shaped fibers less than 5 nm wide. The unique properties provided by the nanometric structure have led to a number of diagnostic biological probes, display devices due to their unique size-dependent medical applications. Bacterial cellulose matrix extracellular is a novel biotechnology and unique medicine indicated for ultimate chronic wound treatment management, drug delivery, tissue engineering, skin cancer and offers an actual and effective solution to a serious medical and social problem and to promote rapid healing in lesions caused by Diabetic burns, ulcers of the lower limbs or any other circumstance in which there's epidermal or dermal loss. In this work, it is reported novel antimicrobial peptides (AMPs) bacterial cellulose/polyhexanide biguanide (PHMB) which are produced by symbioses culture between polyhexanide biguanide and green tea culture medium resulting in the pure 3-D structure consisting of an ultra-fine network of novel biocellulose/PHMB nanofibres matrix (2-8 nm), highly hydrated (99% in weight), and with higher molecular weight, full biocompatibility. © 2014 American Scientific Publishers, All rights reserved.


Acasigua G.A.X.,Federal University of Rio Grande do Sul | de Olyveira G.M.,Sao Paulo State University | Costa L.M.M.,Federal University of ABC | Braghirolli D.I.,Federal University of Rio Grande do Sul | And 6 more authors.
Current Stem Cell Research and Therapy | Year: 2014

Bacterial cellulose (BC) has become established as a remarkably versatile biomaterial and can be used in a wide variety of applied scientific applications, especially for medical devices. In this work, the bacterial cellulose fermentation process is modified by the addition of hyaluronic acid and gelatin (1% w/w) to the culture medium before the bacteria is inoculated. Hyaluronic acid and gelatin influence in bacterial cellulose was analyzed using Transmission Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). Adhesion and viability studies with human dental pulp stem cells using natural bacterial cellulose/hyaluronic acid as scaffolds for regenerative medicine are presented for the first time in this work. MTT viability assays show higher cell adhesion in bacterial cellulose/gelatin and bacterial cellulose/ hyaluronic acid scaffolds over time with differences due to fiber agglomeration in bacterial cellulose/gelatin. Confocal microscopy images showed that the cell were adhered and well distributed within the fibers in both types of scaffolds. © 2014 Bentham Science Publishers.


Olyveira G.M.,Sao Paulo State University | Costa L.M.M.,Federal University of ABC | Basmaji P.,Innovatecs Biotechnology Research and Development
Journal of Biomaterials and Tissue Engineering | Year: 2013

Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, especially for medical devices. In fact, biomedical devices recently have gained a significant amount of attention because of increased interesting tissue-engineered products for both wound care and the regeneration of damaged or diseased organs. The architecture of BC materials can be engineered over length scales ranging from nano to macro by controlling the biofabrication process, besides, surface modifications bring a vital role in in vivo performance of biomaterials. In this work, bacterial cellulose fermentation was modified with carbon nanotubes for sensor applications and diseases diagnostic. SEM images showed that polymer modified-carbon nanotube (PVOH-carbon nanotube) produced well dispersed system and without agglomeration. Influences of carbon nanotube in bacterial cellulose were analyzed by FTIR. TGA showed higher thermal properties of developed bionanocomposites. © 2013 American Scientific Publishers, All rights reserved.


Olyveira G.M.,Federal University of ABC | Acasigua G.A.X.,Federal University of Rio Grande do Sul | Costa L.M.M.,Federal University of ABC | Scher C.R.,Federal University of Rio Grande do Sul | And 4 more authors.
Journal of Biomedical Nanotechnology | Year: 2013

Adhesion and Viability study with human dental pulp stem cell using natural nanotolith/bacterial cellulose scaffolds for regenerative medicine are presented at first time in this work. Nanotolith are osteoinductors, i.e., they stimulate bone regeneration, enabling higher cells migration for bone tissue regeneration formation. This is mainly because nanotoliths are rich minerals present in the internal ear of bony fish. In addition, are part of a system which acts as a depth sensor and balance, acting as a sound vibrations detector and considered essential for the bone mineralization process, as in hydroxiapatites. Nanotoliths influence in bacterial cellulose was analyzed using transmission infrared spectroscopy (FTIR). Results shows that fermentation process and nanotoliths agglomeration decrease initial human dental pulp stem cell adhesion however tested bionanocomposite behavior has cell viability increase over time. Copyright © 2013 American Scientific Publishers All rights reserved.

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