Mallet J.-F.,University of Ottawa |
Duarte J.,University of Ottawa |
Vinderola G.,CONICET |
Anguenot R.,InnoVactiv Inc. |
And 2 more authors.
Nutrition | Year: 2014
Objective: Peptides derived from natural sources can act as immunomodulating agents and prevent infections. The aim of this study was to investigate the immunopotentiating and protective effects of a shark-derived protein hydrolysate (SPH) against an enterotoxigenic Escherichia coli H10407 infection in a murine model. Methods: Mice were fed an aqueous solution of SPH for 7 days before being inoculated with an experimental enterotoxigenic Escherichia coli H10407 infection. After euthanasia, small intestines were removed for histological study and the number of IgA and IgG producing cells was determined by direct immunofluorescence. Cytokines were measured in the serum and the intestinal fluid. Results: The oral administration of SPH enhanced the gut barrier function via up-regulation of immunoglobulin A-producing cells and intestinal cytokines production, including interleukin-6 and tumor necrosis factor-α. The increase of transforming growth factor-β and interleukin-10 contribute to the down-regulation of uncontrolled-inflammatory reaction induced by E. coli infection. From these results, the anti-inflammatory properties of SPH may be caused by regulation and priming mechanisms of the immune system. Conclusion: Enzymatic protein degradation confers immunomodulating and protective potentials to shark proteins and the resulted peptides could be used as an alternative therapy to reduce the risk of bacterial infections and inflammatory-related diseases. © 2014 Elsevier Inc.
Roy M.-C.,University of Québec |
Anguenot R.,InnoVactiv inc. |
Fillion C.,InnoVactiv inc. |
Beaulieu M.,InnoVactiv inc. |
And 2 more authors.
Food Research International | Year: 2011
The ability of naturally occurring polyphenols and phlorotannins (PHTs) from some species of brown seaweeds to inhibit α-amylase and α-glucosidase enzymes in vitro has already been demonstrated. This study aimed at validating the efficacy of a new food ingredient extracted from Ascophyllum nodosum and Fucus vesiculosus PHTs at inhibiting digestive enzymes in vitro and slowing carbohydrate absorption in vivo. In vitro, the PHT extract completely inhibited in a dose-dependent fashion α-amylase and α-glucosidase with very low IC50 values compared to other plant polyphenols. In animals, the PHT extract was able to reduce the normal increase in postprandial blood glucose seen 30min after a meal by 90% (p<0.05), and consecutively reduce peak insulin secretion by 40%. These results demonstrate the potency of this specific PHT extract to beneficially modulate carbohydrate digestion and assimilation, in a way that would be suitable for use in foods and dietary supplement formulations. © 2011 Elsevier Ltd.
Innovactiv Inc. and Les Biotechnologies Oceanova Inc. | Date: 2010-10-19
A raw material ingredient derived from a mixture of natural algae, namely, Kelp and Bladderwrack, and concentrated in polyphenols for use as an additive to help support a healthy blood glucose level after a meal.
Innovactiv Inc. and Les Biotechnologies Oceanova Inc. | Date: 2011-05-24
A raw material ingredient consisting of a peptide mixture derived from hydrolysed fish protein to maintain intestinal balance.
Innovactiv Inc. | Date: 2012-07-31
Active ingredients, namely, proteins, hydrolyzed proteins, probiotic bacteria, plant extracts, extracts from microorganisms fermentation, for use in the manufacture of nutritional supplements for use in improving and maintaining good function of human beings and animals. Active ingredients, namely, processed algae for human consumption, for use in the manufacture of nutritional supplements for use in improving and maintaining good function of human beings.
InnoVactiv Inc. | Date: 2014-02-28
Innovactiv Inc. | Date: 2013-06-18
Active ingredients, namely marine invertebrate, seaweed, starfish and natural algae for use in the manufacture of natural health products, nutraceuticals and cosmetics. Biotechnological research services in connection with active ingredients used in natural health products, nutraceuticals, cosmetics in the field of human and animal health.
Innovactiv Inc. | Date: 2011-07-19
Raw material ingredient derived from a mixture of natural algae, namely, Kelp and Bladderwrack, and concentrated in polyphenols for use as an additive to help support a healthy blood glucose level after a meal.