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Song S.,Peking Union Medical College | Zheng X.,Inner Mongolia Pharmaceutical Industrial Institute Co. | Liu W.,Inner Mongolia Pharmaceutical Industrial Institute Co. | Du R.,Inner Mongolia Pharmaceutical Industrial Institute Co. | And 2 more authors.
Chemical and Pharmaceutical Bulletin | Year: 2010

Three new flavonol 3-O-glycosides, rhamnetin 3-O-[(S)-3-hydroxy-3-methyl- glutaroyl(1→6)]- β-D-glucopyranoside (1), rhamnocitrin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]- β-D-glucopyranoside (2), and isorhamnetin 3-O-[(S)-3-hydroxy-3-methylglutaroyl(1→6)]- α-L-rhamnopyranosyl(1→2)- β-D-glucopyranoside (3), along with 13 known compounds, were isolated from Oxytropis racemosa TURCZ. Their structures were deduced by means of spectroscopic methods and chemical evidence. 2 and 6 showed cytotoxic activities against HCT-8 (IC 50 6.38 μM) and A549 (IC 50 5.20 μM), respectively. © 2010 Pharmaceutical Society of Japan.


Song S.,Peking Union Medical College | Song S.,Liaoning University of Traditional Chinese Medicine | Zheng X.-P.,Inner Mongolia Pharmaceutical Industrial Institute Co. | Liu W.-D.,Inner Mongolia Pharmaceutical Industrial Institute Co. | And 4 more authors.
Phytochemical Analysis | Year: 2013

Introduction Oxytropis racemosa Turcz is an important minority medicine that is used mainly to improve children's indigestion, especially in inner Mongolia and Tibet. Previous studies indicated that the characteristic constituents of this plant are acylated flavonoids. Objective Rapidly identify the characteristic chemical constituents of O. racemosa by high-performance liquid chromatography-diode array detection-electrospray ionisation/multi-stage mass spectrometry (HPLC-DAD-ESI/MSn) and suggest a useful method to control the quality of this medicinal plant. Methods In the HPLC fingerprint, 32 flavonoids were tentatively identified by a detailed analysis of their mass spectra, UV spectra and retention times. Furthermore, 13 flavonoids were confirmed by comparison with previously isolated compounds obtained from O. racemosa. Results In total, 32 flavonoids, including 13 flavonoids with 3-hydroxy-3-methylglutaric acid (HMG) moieties and four flavonoids with 3-malonyl moieties, were identified in the extract of O. racemosa. Among the compounds identified, 10 were characterised as new compounds for their particular acylated sugar moieties. Conclusions The method described is effective for obtaining a comprehensive phytochemical profile of plants containing unstable acylated flavonoids. The method is also useful for constructing the chromatographic fingerprint of the minority medicine -O. racemosa Turcz for quality control. © 2012 John Wiley & Sons, Ltd.


Xu J.-F.,Peking Union Medical College | Zheng X.-P.,Inner Mongolia Pharmaceutical Industrial Institute Co. | Liu W.-D.,Inner Mongolia Pharmaceutical Industrial Institute Co. | Du R.-F.,Inner Mongolia Pharmaceutical Industrial Institute Co. | And 2 more authors.
Journal of Asian Natural Products Research | Year: 2010

Potentilin A (1), a rare diflavonol ester of μ-truxinic acid and a new normonoterpenoid, 2,6-dimethyl-2,3-dihydro-4-oxo-4H-pyran-2-acetic acid (2), was isolated from Potentilla anserina, together with 19 known flavonol glycosides (3-21) and 2 known monterpenoids (22,23). Their structures were elucidated by means of UV, IR, HR-ESI-MS, 1D and 2D NMR spectroscopic data. © 2010 Taylor & Francis.

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