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Wang B.,Inner Mongolia General Forestry Hospital | Zhang Y.,Inner Mongolia General Forestry Hospital
Zhonghua Shiyan Yanke Zazhi/Chinese Journal of Experimental Ophthalmology | Year: 2017

Long noncoding RNAs (IncRNAs) are non-protein coding transcript larger than 200 nucleotides, making up a large fraction of cellular transcripts in mammalian. Recent years have seen a surge of studies aimed at functionally characterizing the role of IncRNAs in development and disease. It has been proved that this kind of noncoding RNAs regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels. Retinal development is dependent on an accurately functioning network of transcriptional and translational regulators. Among the diverse classes of molecules involved, IncRNAs play a significant role. LncRNAs are known or suspected to play a functional role in the specification and maturation of retinal cell subtypes and involved in several ocular related diseases. Though the molecular mechanism of most IncRNAs is still largely unclear, it is likely that these molecules represent a major component involved in retinal cell fate determination. In the process of retinal development, IncRNAs could induce cell differentiation, affect cell cycle and regulate X chromosome inactivation. IncRNAs also play an important role in ocular diseases, such as anophthalmia, diabetic retinopathy and spinocerebellar movement disorder type 7. This manuscript reviewed recent advances in the role of IncRNAs in retinal development and ocular diseases, and the existing problems, which is of great significance for basic and clinical research and the development of new therapeutic target. Copyright © 2017 by the Chinese Medical Association.

Wang Z.-D.,Jilin Agricultural University | Wang Z.-D.,Chinese Academy of Agricultural Sciences | Wang Z.-D.,Academy of Military Medical science | Liu H.-H.,Academy of Military Medical science | And 9 more authors.
Frontiers in Microbiology | Year: 2017

Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included. The estimated pooled prevalence of T. gondii infection in immunocompromised patients and the control was 35.9 and 24.7% (p < 0.001), with an OR of 2.24, i.e., 42.1 and 32.0% for HIV/AIDS patients and the control (p < 0.05), 26.0 and 12.1% for cancer patients and the control (p < 0.001), and 42.1 and 34.5% for transplant recipients and the control (p > 0.05), whose estimated pooled ORs were 1.92 (95% CI, 1.44-2.55), 2.89 (95% CI, 2.36-3.55), and 1.51 (95% CI, 1.16-1.95), respectively. This study is the first to demonstrate that the immunocompromised patients are associated with higher odds of T. gondii infection, and appropriate prevention and control measures are highly recommended for these susceptible populations. © 2017 Wang, Liu, Ma, Ma, Li, Yang, Zhu, Xu, Wei and Liu.

Zhuang L.,Shanghai JiaoTong University | Zhao Y.,Inner Mongolia General Forestry Hospital | Zhao W.,Shanghai JiaoTong University | Li M.,Shanghai JiaoTong University | And 12 more authors.
Molecular and Cellular Biochemistry | Year: 2015

Conflicting associations between define (KCNJ11) variations and susceptibility to late-onset (>40 years old) type 2 diabetes mellitus (T2DM) have been reported in different ethnic groups. We investigated whether the E23K (G→A, rs5219) or A190A (C→T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood pressure in the Chinese population. Case-control study of 175 unrelated Chinese patients with early-onset T2DM (age of onset <40 years old) who receive (ins+, n = 57) or do not receive insulin (ins−, n = 118), and 182 non-diabetic control subjects. PCR-direct sequencing was performed to genotype E23K and A190A; the genotypic frequencies and associations with clinical characteristics were analyzed. The genotypic frequencies of E23K-GA+AA were higher and A190A-TT was lower in the early-onset T2DM group, especially the T2D-ins+ group, compared to the non-diabetic control group (p < 0.01 or 0.05, respectively). In non-diabetic subjects, E23K-AA carriers had significantly higher 2 h plasma glucose and lower 2 h insulin than E23K-GG carriers (both p < 0.05). A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05). In the T2DM ins+ group, E23K-AA carriers had lower onset age and duration of diabetes and higher BMI than GG carriers, and A190A-TT carriers had higher SBP than CC carriers (all p < 0.05). The E23K-GA or AA genotypes may increase the susceptibility to early-onset T2DM, while A190A-TT may protect against early-onset T2DM. On the other hand the A190A-TT or E23K-GG genotypes may increase the risk of hypertension in the Chinese population. © 2015, Springer Science+Business Media New York.

Sun Z.-W.,Inner Mongolia General Forestry Hospital
International Journal of Ophthalmology | Year: 2010

• AIM: To analyze the curative effect of various methods to search nasal side lacrimal canaliculus and inserting epidural sebific duct. • METHODS: Under microscopy, anastomosis was carried out using an epidural duct in cases diagnosed with ruptured lacrimal canaliculus preoperatively. • RESULTS: The success ratio of operation was 100%, flushing of lacrimal passage was unobstructed. • CONCLUSION: Raise the success ratio of operation and decrease the symptoms of dacryorrhea can improve the patients'.

Du Y.,Suzhou University | Du Y.,Inner Mongolia General Forestry Hospital | Li Y.,Inner Mongolia General Forestry Hospital | Lan Q.,Suzhou University
Neurology India | Year: 2011

Background: Evaluation of the degree of severity of injury, coma duration, and prediction of outcome are integral parts of present-day management of severe traumatic brain injury (TBI). Objective: To investigate whether evaluation and prediction of outcome in early phase after severe TBI is possible by means of single-voxel proton magnetic resonance spectroscopy ( 1 H-MRS). Materials and Methods: Proton spectra were acquired from the posterior part of normal-appearing frontal lobes having predominantly white matter in 72 patients with severe TBI within a few days of trauma, mean 9.5 days and also in 30 controls. Results: 1 H-MRS studies revealed lower ratios of N-acetylaspartate (NAA)/Choline (Cho) and NAA/ Creatine (Cr) and higher ratios of Cho/Cr in patients with TBI when compared to the control group. In patients with severe TBI, NAA/Cr, NAA/Cho and Cho/Cr ratios were significantly correlated with the initial Glasgow Coma Scale score (GCS) (P=0.004, r =0.439, P=0.018, r =0.364, P=0.004, r = -0.762, respectively), and with the clinical outcome, Glasgow Outcome Scores (GOS) (P=0.006, r =0.414; P=0.007, r =0.412; P=0.016, r = -0.775, respectively). An equation including clinical and spectroscopic variables, which can predict coma duration fairly accurately, was also obtained. Conclusions: 1 H-MRS may be a novel method of assessing brain function, estimating coma duration, and predicting outcome in patients with severe TBI.

Zhang Y.,Inner Mongolia General Forestry Hospital
International Eye Science | Year: 2012

AIM: To compare therapeutic effect in surgical removal of idiopathic epimacular membrane(IEM) with transconjuctival sutureless 23-gauge(23G) vitrectomy and conventional 20-gauge(20G) vitrectomy. METHODS: Fifty-six cases 56 eyes with IEM underwent either 23-or 20-gauge vitrectomy from March 2008 to June 2011. Main outcome measures included visual acuity(VA), intraocular pressure(IOP), operative complications and surgical time. Postoperative mean follow up was 16 months. RESULTS: The VA increased three months after surgery in 23G group. The logMAR at day 1, week 1 and month 3 was 1.78±0.94, 1.51±0.88, 1.48±0.91, respectively. The differences between the three time points and preoperative baseline was significant (t=3.3917, P=0.003; t=11.1779, P=0.0000; t=4.3424, P=0.0000). The VA of the three points was logMAR=2.11±1.00, 1.93±1.02, 1.64±1.00 respectively in 20G group. The differences between postoperative week 1, month 3 and preoperative baseline was significant(t=2.3578, P=0.033; t=3.5552, P=0.003). The intergroup differences at the three time point was not significant(t=0.9582, P=0.34; t=1.2761, P=0.211; t=0.4897, P=0.628). The mean IOP at day 1, week 1 and month 3 in 23G group was 11.62±9.7, 15.86±6.6, 16.84±5.6mmHg while in 20G group was 18.56±7.71, 15.33±5.21, 14.72±3.56mmHg, respectively. The differences of IOP at day 1 was significant(P<0.001). The mean surgical time of 23G group 41.20±7.47 minutes was significantly less than that of 20G group(52.28±7.11 minutes, P<0.001). No endophthalmitis or retinal detachment was found in both 23G and 20G group. Postoperative discomfort and intraocular inflammation were significantly reduced in the 23-gauge group. CONCLUSION: The 23G TSV system is a safe and efficient surgical technique for IEM surgery. Operating time is significantly reduced, minimizing surgery-induced trauma, and reducing the patients' discomfort.

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