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Zhuang L.,Shanghai JiaoTong University | Zhao Y.,Inner Mongolia General Forestry Hospital | Zhao W.,Shanghai JiaoTong University | Li M.,Shanghai JiaoTong University | And 12 more authors.
Molecular and Cellular Biochemistry | Year: 2015

Conflicting associations between define (KCNJ11) variations and susceptibility to late-onset (>40 years old) type 2 diabetes mellitus (T2DM) have been reported in different ethnic groups. We investigated whether the E23K (G→A, rs5219) or A190A (C→T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood pressure in the Chinese population. Case-control study of 175 unrelated Chinese patients with early-onset T2DM (age of onset <40 years old) who receive (ins+, n = 57) or do not receive insulin (ins−, n = 118), and 182 non-diabetic control subjects. PCR-direct sequencing was performed to genotype E23K and A190A; the genotypic frequencies and associations with clinical characteristics were analyzed. The genotypic frequencies of E23K-GA+AA were higher and A190A-TT was lower in the early-onset T2DM group, especially the T2D-ins+ group, compared to the non-diabetic control group (p < 0.01 or 0.05, respectively). In non-diabetic subjects, E23K-AA carriers had significantly higher 2 h plasma glucose and lower 2 h insulin than E23K-GG carriers (both p < 0.05). A190A-TT or E23K-GG carriers had higher systolic blood pressure (SBP) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05). In the T2DM ins+ group, E23K-AA carriers had lower onset age and duration of diabetes and higher BMI than GG carriers, and A190A-TT carriers had higher SBP than CC carriers (all p < 0.05). The E23K-GA or AA genotypes may increase the susceptibility to early-onset T2DM, while A190A-TT may protect against early-onset T2DM. On the other hand the A190A-TT or E23K-GG genotypes may increase the risk of hypertension in the Chinese population. © 2015, Springer Science+Business Media New York.


Sun Z.-W.,Inner Mongolia General Forestry Hospital
International Journal of Ophthalmology | Year: 2010

• AIM: To analyze the curative effect of various methods to search nasal side lacrimal canaliculus and inserting epidural sebific duct. • METHODS: Under microscopy, anastomosis was carried out using an epidural duct in cases diagnosed with ruptured lacrimal canaliculus preoperatively. • RESULTS: The success ratio of operation was 100%, flushing of lacrimal passage was unobstructed. • CONCLUSION: Raise the success ratio of operation and decrease the symptoms of dacryorrhea can improve the patients'.


Du Y.,Suzhou University | Du Y.,Inner Mongolia General Forestry Hospital | Li Y.,Inner Mongolia General Forestry Hospital | Lan Q.,Suzhou University
Neurology India | Year: 2011

Background: Evaluation of the degree of severity of injury, coma duration, and prediction of outcome are integral parts of present-day management of severe traumatic brain injury (TBI). Objective: To investigate whether evaluation and prediction of outcome in early phase after severe TBI is possible by means of single-voxel proton magnetic resonance spectroscopy ( 1 H-MRS). Materials and Methods: Proton spectra were acquired from the posterior part of normal-appearing frontal lobes having predominantly white matter in 72 patients with severe TBI within a few days of trauma, mean 9.5 days and also in 30 controls. Results: 1 H-MRS studies revealed lower ratios of N-acetylaspartate (NAA)/Choline (Cho) and NAA/ Creatine (Cr) and higher ratios of Cho/Cr in patients with TBI when compared to the control group. In patients with severe TBI, NAA/Cr, NAA/Cho and Cho/Cr ratios were significantly correlated with the initial Glasgow Coma Scale score (GCS) (P=0.004, r =0.439, P=0.018, r =0.364, P=0.004, r = -0.762, respectively), and with the clinical outcome, Glasgow Outcome Scores (GOS) (P=0.006, r =0.414; P=0.007, r =0.412; P=0.016, r = -0.775, respectively). An equation including clinical and spectroscopic variables, which can predict coma duration fairly accurately, was also obtained. Conclusions: 1 H-MRS may be a novel method of assessing brain function, estimating coma duration, and predicting outcome in patients with severe TBI.


Zhang Y.,Inner Mongolia General Forestry Hospital
International Eye Science | Year: 2012

AIM: To compare therapeutic effect in surgical removal of idiopathic epimacular membrane(IEM) with transconjuctival sutureless 23-gauge(23G) vitrectomy and conventional 20-gauge(20G) vitrectomy. METHODS: Fifty-six cases 56 eyes with IEM underwent either 23-or 20-gauge vitrectomy from March 2008 to June 2011. Main outcome measures included visual acuity(VA), intraocular pressure(IOP), operative complications and surgical time. Postoperative mean follow up was 16 months. RESULTS: The VA increased three months after surgery in 23G group. The logMAR at day 1, week 1 and month 3 was 1.78±0.94, 1.51±0.88, 1.48±0.91, respectively. The differences between the three time points and preoperative baseline was significant (t=3.3917, P=0.003; t=11.1779, P=0.0000; t=4.3424, P=0.0000). The VA of the three points was logMAR=2.11±1.00, 1.93±1.02, 1.64±1.00 respectively in 20G group. The differences between postoperative week 1, month 3 and preoperative baseline was significant(t=2.3578, P=0.033; t=3.5552, P=0.003). The intergroup differences at the three time point was not significant(t=0.9582, P=0.34; t=1.2761, P=0.211; t=0.4897, P=0.628). The mean IOP at day 1, week 1 and month 3 in 23G group was 11.62±9.7, 15.86±6.6, 16.84±5.6mmHg while in 20G group was 18.56±7.71, 15.33±5.21, 14.72±3.56mmHg, respectively. The differences of IOP at day 1 was significant(P<0.001). The mean surgical time of 23G group 41.20±7.47 minutes was significantly less than that of 20G group(52.28±7.11 minutes, P<0.001). No endophthalmitis or retinal detachment was found in both 23G and 20G group. Postoperative discomfort and intraocular inflammation were significantly reduced in the 23-gauge group. CONCLUSION: The 23G TSV system is a safe and efficient surgical technique for IEM surgery. Operating time is significantly reduced, minimizing surgery-induced trauma, and reducing the patients' discomfort.

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