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Zhang Y.,Inner Mongolia Forestry General Hospital
International Eye Science | Year: 2012

AIM: To evaluate the effects ofpars plana vitrectomy(PPV) combined with internal limiting membrane peeling for the treatment of macular edema secondary to retinal vein occlusion (RVO). METHODS: Twelve cases of visual loss due to macular edema caused by central RVO or branch RVO underwentPPV combined with internal limiting membrane peeling. Best-corrected visual acuity (BCVA) and central foveal thickness by optical coherence tomography(OCT) were measured pre- and postoperatively then compared to assess the outcome of surgery. RESULTS: In all cases retinalthickeness diminished within 2 months of surgery. Visual acuity improved in all of the central RVO cases and 4 out of 8 branch RVO cases. The decrease in macular thickness was statistically significant (mean postoperative macular thickness 361±61.1μm versus mean preoperative macular thickness 563.9±90.0μm, P=0.001, t-test). The improvement in BCVA was not statistically significant (mean preoperative BCVA in LogMAR 1.23±0.29 versus mean postoperative BCVA in LogMAR 1.06±0.49, P=0.09, t-test). CONCLUSION: In eyes with macular edema secondary to RVO, PPV combined with internal limiting membrane peeling can resolve macular edema, but the improvement in BCVA was not statistically significant in this study.


Han Y.,Capital Medical University | Wang X.-B.,Inner Mongolia Forestry General Hospital | Xiao N.,Capital Medical University | Liu Z.D.,Capital Medical University
Asian Pacific Journal of Cancer Prevention | Year: 2013

Background: To explore mRNA expression and clinical significance of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in tumor tissue of postoperative patients with non-small cell lung cancer (NSCLC). Materials and Methods: Sixty NSCLC patients undergoing radical operation in our hospital from Nov., 2011 to Jun., 2012 were selected. Plasmid standards of ERCC1, BRCA1, RRM1, TYMS and TUBB3 were established and standard curves were prepared by SYBR fluorescent real-time quantitative PCR analysis. Samples from tumor centers were taken to detect mRNA expression of ERCC1, BRCA1, RRM1, TYMS and TUBB3 genes in cancerous tissue during operation. The total mRNA expression quantities were compared according to different clinical characteristics. Results: The total expression quantities of 5 genotypes from high to low were ERCC1>RRM1>TUBB3>TYMS>BRCA1 in turn. By pairwise comparisons, other differences showed statistical significance (p<0.05 or p<0.01) except for TYMS and TUBB3 (p>0.05); the low expression rates from high to low were ERCC1>TYMS>TUBB3>TUBB3>RRM1>BRCA1 in turn. The expression quantities of BRCA1, RRM1 and TYMS in males, smokers and patients without adenocarcinoma were all significantly higher than that in females, non-smokers and patients with adenocarcinoma, and significant differences were present (p<0.05 or p<0.01). In terms of pathological staging, the expression quantities of BRCA1, RRM1 and TYMS in phases a~b and a~b had a tendency to be greater than in phases and. Conclusions: Resistance to chemotherapy and sensitivity to targeted therapy differ among patients with NSCLC. Differences in gene expression in different individuals were also revealed. Only according to personalized detection results can individualized therapeutic regimens be worked out, which is a new direction for oncotherapy.


Zhang Y.,Inner Mongolia Forestry General Hospital
International Eye Science | Year: 2012

AIM: To evaluate the safety and efficacy of 23-gauge transconjunctival sutureless pars plana vitrectomy for rhegmatogenous retinal detachment(RRD). METHODS: Totally 26 consecutive cases(26 eyes) were recruited between March 2010 and June 2011. All surgeries were performed with the 23-gauge technique. Main outcome measures included visual acuity, intraocular pressure, operative complications. Postoperative mean follow-up were 3 months. RESULTS: Anatomical success was achieved in 81% of 21 cases with single surgery and rose to 96% of 25 cases with additional surgery. Mean visual acuity improved in 21 cases (80%), unchanged in 3 cases(12%), declined in 2 cases (8%). The differences of intraocular pressure at postoperative 1 day was significant (P < 0.01). Two cases with ocular hypotony (intraocular pressure ss6mmHg), sustained for 2 weeks and did not occur choroidal detachment. CONCLUSION: Acceptable anatomical and functional success rates can be achieved with 23-gauge transconjunctival sutureless vitrectomy for RRD. The main advantages of this technique are lost in RRD surgery and had to faced higher failure rate.


Wang X.-B.,Inner Mongolia Forestry General Hospital | Li J.,Capital Medical University | Han Y.,Capital Medical University
Tumor Biology | Year: 2014

Observational studies on the prognostic role of preoperative serum carcinoembryonic antigen (CEA) in non-small cell lung cancer (NSCLC) are controversial. Electronic databases updated until June 1, 2014 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between preoperative serum CEA level and survival of patients with NSCLC. Survival data were aggregated and quantitatively analyzed. We performed a meta-analysis of 16 studies (n= 4,296 patients) that evaluated the correlation between preop-erative serum CEA level and survival in patients with NSCLC. Combined hazard ratios suggested that preoperative serum CEA over expression was associated with poor prognosis of overall survival (OS) (hazard ratio (HR)=2.28, 95% confidence interval (CI) 2.24–2.31) in patients with NSCLC. Meanwhile, for p-stage I NSCLC, the HR (95% CI) was 1.98 (1.73–2.15). In the stratified analysis by patient source, significant risks were found among Asians and non-Asians. However, significant heterogeneity was observed among all studies. In the present meta-analysis, preoperative serum CEA over expression indicates a poor prognosis for patients with NSCLC. © International Society of Oncology and BioMarkers (ISOBM) 2014


Wang X.-B.,Inner Mongolia Forestry General Hospital | Li Y.-S.,Capital Medical University | Li J.,Capital Medical University | Han Y.,Capital Medical University | Liu Z.-D.,Capital Medical University
Journal of Cellular and Molecular Medicine | Year: 2015

Many studies have examined the association between the interleukin-8 -251T/A (rs4073) gene polymorphism and lung cancer risk in various populations, but the results have been inconsistent. In this meta-analysis, PubMed was searched for case-control studies published through 01 December 2013. The data were extracted, and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. We assessed six published studies on the association between the interleukin-8 -251T/A polymorphism and lung cancer risk. The included studies yielded a total of 3265 lung cancer cases and 3607 controls. For the homozygous A/A and A allele carriers (T/A + A/A), the pooled ORs for all studies combining 3265 cases and 3607 controls were 1.03 (95% CI = 0.92-1.14; P = 0.235 for heterogeneity) and 1.07 (95% CI = 0.96-1.19; P = 0.245 for heterogeneity) when compared with the homozygous wild-type genotype (T/T). When the analysis was stratified by ethnicity, significant risks were found among Asians for both the A allele carriers and the homozygous A/A individuals. However, no significant associations were found in non-Asian populations using any of the genetic models. This meta-analysis suggests that the interleukin-8 -251A allele confer an increased risk for the development of lung cancer among Asians. © 2015 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

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