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Zhang Z.-Z.,Inner Mongolia Center for Endemic Disease Control and Research
Chinese Journal of Endemiology | Year: 2013

Objective: To investigate the current status of iodine deficiency disorders (IDD) in Inner Mongolia Autonomous Region, residents iodine nutrition level and preventive measures being implemented, so as to master the background status of residents iodine nutrition before introduction of new concentration standards of iodized salt in the autonomous region; and to evaluate the effect of interventions implemented. Methods: According to stratified sampling with probability proportional to size(PPS), a sample of 30 units was extracted, and then a primary school was extracted from each sampling unit. From each primary school 40 students aged 8-10(male and female half and half) were checked thyroid volume though B-ultrasonic and iodine content of edible salt in these students' homes was quantitatively determined. Around the primary school, 3 villages were randomly selected, and then 5 pregnant and 5 lactating women were selected. Urinary iodine was measured by ammonium persulfate digestion-arsenic cerium catalysis spectrophotometry. Children urinary iodine level monitoring: In each county (city, district, flag) 1 village (town, district office) was randomly selected according to its sub-area positions in the north, the south, the east, the west and the center of the county; and then a village primary school (in the absence of village primary school, township central primary school was selected) was selected; from each school 20 children aged 8-10 were selected. A total of 100 urine samples were tested in each county. Results: Goiter rate of children aged 8-10 was 3.1%(37/1206); median urinary iodine level(UI) was 259.9 μg/L; the median of residents consumption of iodized salt was 30.2 mg/kg; the coverage rate of iodized salt was 99.3% (1194/1203); the consumption rate of iodized salt was 98.1% (1184/1203); the qualified rate of iodized salt was 98.8% (1180/1194); the rate of non-iodized salt was 0.7% (8/1203) and failure rate was 1.2%(15/1203). The number of urine sample was 6993; the median urinary iodine was 249.0 μg/L in children age 8-10, and UI level lower than 50.0 μg/L accounted for 1.50% (105/1993). Conclusions: After salt iodization as main comprehensive measures in prevention and control of iodine deficiency disorders, remarkable progress has been made in Inner Mongolia. The coverage rate of iodized salt, the consumption of iodized salt, goiter rate, and UI median all have reached the standard of elimination of iodine deficiency disorders. Children iodine nutrition level is in enough state, pregnant and lactating women iodine nutrition level is in suitable condition. Source

Liu J.,Inner Mongolia Center for Endemic Disease Control and Research
Chinese Journal of Endemiology | Year: 2012

Objective: To evaluation the intervention effects of hand hold hands method in brick tea borne fluorosis. Method: Four to six grade pupils were selected in brick tea borne fluorosis areas, and health education knowledge questionnaire investigation was conducted. Drinking tea related health behaviors were also surveyed by the method of questionnaire. Then health education lecture on brick tea borne fluorosis was carried out, and health education material and low fluoride brick tea were provided to the pupils, the students were also requested to tell their parents brick tea related knowledge and supervise them to get rid of harmful drinking tea behavior, and cultivate healthy lifestyle. One year later pupils ' health knowledge questionnaire and parents health related behavior questionnaire were carried out once again. The knowledge awareness rates of students before and after the intervention were compared. Health related behavior change rates of the parent between different ages and education levels were compared, and the implementation rates of different brick tea related behaviors before and after the intervention were compared. Results: After 1 year of health education, the student's knowledge awareness rate on brick tea fluorosis was [94.3%(33/35)], compared with the rate before intervertion[14.3%(5/35)] increased significantly (χ2 = 46.111, P < 0.01). The overall behavior change rate of health related behavior was 68.6%. After the intervention, the implementation rate of whether drinking tea, drinking overnight tea, drinking boiled for a long time tea decreased(P< 0.01). But the behavior implementation rates of drinking tea with milk, drinking and buying low fluoride brick tea significandy increased(P < 0.05). Implementation rate of whether drinking brick tea did not change significantly(P > 0.05). Conclusions: Through hand hold hands health education intervention, the knowledge awareness of students on brick tea fluorosis increases, and their parents can actively change bad tea drinking habits, and cultivate healthy lifestyle. Source

Guo H.,Inner Mongolia Center for Endemic Disease Control and Research
Wei sheng yan jiu = Journal of hygiene research | Year: 2011

By measure the changes of serumal estadiol and progesterone levels of kunming female mice, which are chronically exposed to different concentrations of arsenic trioxide, discuss the estrogen-like effects of arsenic. Select the Kunming female mice exposed to different drinking water of arsenic trioxide (0, 0.05, 0.10, 0.20, 0.40 microg/ml) for 20 weeks as the research subjects in this study. Use the method of radioimmunology to measure concentrations of serumal estadiol and progesterone of female adult mice. Compared with the control group, there exists the changes of the concentrations of the serumal estadiol and progesterone of Km female adult mice, which are chronically exposed to the arsenic. Compared to the control group, the differences of the concentrations of the serumal estadiol in the 0.05 microg/ml group and 0.10 microg/ml group have no statistical significance (P > 0.05), the concentrations of estadiol in the 0.20 microg/ml group (P < 0.01) and 0.40 microg/ ml group (P < 0.05) decrease. Compared to the control group, the differences of the concentrations of the serumal progesterone in the 0.05 microg/ml group, 0.20 microg/ml group and 0.40 microg/ml group have no statistical significance (P > 0.05), the concentration of serumal progesterone in the 0.10 microg/ml group (P < 0.01) decrease. Chronically arsenic exposure can interfere the levels of serumal hormones. Arsenic has the estrogen-like effects. Source

Rice R.H.,University of California at Davis | Xia Y.,Inner Mongolia Center for Endemic Disease Control and Research | Alvarado R.J.,University of California at Davis | Phinney B.S.,University of California at Davis
Journal of Proteome Research | Year: 2010

Shotgun proteomic analysis of the human nail plate identified 144 proteins in samples from Causcasian volunteers. The 30 identified proteins solubilized by detergent and reducing agent, 90% of the total nail plate mass, were primarily keratins and keratin associated proteins. Keratins comprised a majority of the detergent-insoluble fraction as well, but numerous cytoplasmic, membrane, and junctional proteins and histones were also identified, indicating broad use by transglutaminases of available proteins as substrates for cross-linking. Two novel membrane proteins were identified, also found in the hair shaft, for which mRNAs were detected only at very low levels by real-time polymerase chain reaction in other tissues. Parallel analyses of nail samples from volunteers from Inner Mongolia, China gave essentially the same protein profiles. Comparison of the profiles of nail plate and hair shaft from the latter volunteers revealed extensive overlap of protein constituents. Analyses of samples from an arsenic-exposed population revealed few proteins whose levels were altered substantially but raised the possibility of detecting sensitive individuals in this way. © 2010 American Chemical Society. Source

Wang Y.,Inner Mongolia Agricultural University | Li J.-Y.,Inner Mongolia Center for Endemic Disease Control and Research | Han M.,Inner Mongolia Agricultural University | Wang W.-L.,Inner Mongolia Agricultural University | Li Y.-Z.,Inner Mongolia Agricultural University
Lipids in Health and Disease | Year: 2015

Abstract Background: The incidence of nonalcoholic fatty liver disease (NAFLD) has been increasing worldwide in parallel with the obesity epidemic. This study aims to investigate the effects of the total flavonoids in Stellera chamaejasme L. (TFSC) on the experimental NAFLD in high fat diet fed (HFD) rats. Methods: NAFLD model was induced in male Wistar rats by high-fat diet, and the rats in NAFLD group were randomized into NAFLD group (n = 20) and TFSC-treated group (n = 60). Both groups were given high-fat diet, and the normal group (n = 20) was given normal diet. In addition, the TFSC treated group was administered TFSC orally once a day at a low dose of 100 mg/kg (n = 20), medium dose of 200 mg/kg (n = 20), and high dose of 400 mg/kg (n = 20) for 6 weeks. Subsequently, the rats were sacrificed and body weight changes, lipid profiles in plasma and liver pathology were examined. The relative levels of fatty acid synthesis and β-oxidation gene expression in hepatic tissues were measured by quantitative real-time polymerase chain reaction (RT-PCR). Results: After the HFD administration for 4 weeks, the body weight,serum TC and TG levels in the rat of model group were significantly higher than in normal group (P < 0.05), and which Showed that the experimental NAFLD model was successfully established. While continual feeding with HFD deteriorated NAFLD and hyperlipidemia, and treatment with the different doses of TFSC effectively improved serum and liver lipid metabolism and liver function. A linear relationship between the dose of TFSC and blood lipid level was observed. The mRNA expression of hepatic acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), Leptin (LEP) and sterol regulatory element binding protein (SREBP)-1c as well as peroxisome proliferator-activated receptor (PPAR) -γ were significantly lower in high-dose group compared to the positive control group (P < 0.05). The hepatic mRNA expression of Cholesterol 7α-hydroxylase1 (CYP7A1), Carnitine palmitoyltransferase-1 (CPT1) and peroxisome proliferator-activated receptor (PPAR) -α were significantly higher in the high-dose group compared to the positive control group (P < 0.05). However, no difference was detected in the middle-dose group or the low-dose group compared to the positive control group (P > 0.05). Conclusion: TFSC treatment effectively improved NAFLD-related hyperlipidemia and inhibited liver steatosis in rats, and accompanied by modulating the expression of genes for regulating lipid metabolism. © 2015 Wang et al. Source

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