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Shi Y.,Peking University | Guo S.,Peoples Hospital of Inner Mongolia Autonomous Region | Bo F.,U.S. Center for Disease Control and Prevention | Zhang X.,Inner Mongolia Medical College | And 2 more authors.
International Journal of Infectious Diseases | Year: 2013

Objectives: The aim of this study was to evaluate the impact of HIV and sexually transmitted disease (STD) prevention interventions among female sex workers (FSWs) in the city of Hohhot in northern China. Methods: Three serial cross-sectional surveys were conducted in 2006, 2007, and 2008 among FSWs. A questionnaire was administered to the FSWs, and HIV and syphilis tests were performed for all participants. Intervention activities including condom promotion and provision, increased condom availability and accessibility, and voluntary HIV counseling and testing (VCT) were carried out among FSWs. Results: There were 624 participants in the 2006 survey, 444 in the 2007 survey, and 451 in the 2008 survey. The United Nations General Assembly Special Session (UNGASS) indicators for FSWs increased from 13.9% in 2006 to 37.7% in 2008 (p< 0.001). The average rate of consistent condom use with commercial clients in the month preceding the interview increased significantly from 39.8% in 2006 to 59.6% in 2008 (p<0.001). Not a single HIV-positive case was found among the FSWs over these 3 years, and the prevalence of syphilis decreased remarkably from 9.5% in 2006 to 1.3% in 2008. Logistic regression analysis showed that sauna or hair salon work venues, receiving services from intervention programs, and accepting HIV tests were factors associated with consistent condom use. Conclusions: The findings suggest that consistent condom use and awareness of HIV/AIDS prevention-related knowledge among FSWs have been improved by the intervention. Further prioritized and combined prevention programs aimed at FSWs are needed in order to prevent the HIV/AIDS epidemic spreading in the general population in China. © 2012 International Society for Infectious Diseases.


Wang J.,Southern Medical University | Wang J.,Peoples Hospital of Inner Mongolia Autonomous Region | Chen T.-Y.,Southern Medical University | Qin S.,Guangdong No2 Provincial Peoples Hospital | And 2 more authors.
Medical Hypotheses | Year: 2013

Diabetes and cancer are both serious health problems worldwide and can lead to a significant burden on society with high incidence. Studies show that diabetes, which may be the reason of cancer metastasis, can increase cancer incidence and mortality. Bone is one of the most preferential metastatic target sites for cancers. Studies also indicate that OPG and RANKL which regulate bone reabsorption play significant roles in the process of bone tumor metastasis. In addition, metformin as a commonly used medicine for type 2 diabetes is a negative regulator of RANKL and inhibits the differentiation of osteoclasts. We present a hypothesis that metformin serves an inhibitory effect on bone metastasis of cancer via OPG/RANKL/RANK system. © 2013 Elsevier Ltd.


Li H.,Hubei University | Li H.,Peoples Hospital of Inner Mongolia Autonomous Region | Ding G.,Hubei University
Clinical Laboratory | Year: 2016

Background: Systemic lupus erythematosus (SLE) is a clinically heterogeneous, human systemic autoimmune disease characterized by autoantibody formation. MicroRNAs (miRNA) have emerged as an important new class of modulators of gene expression and have been confirmed to regulate the lymphocyte tolerance and autoimmunity in SLE. Methods: In this study, we investigated the serum miRNA profile in lupus nephritis (LN) patients with microarray technology. TaqMan-based stem-loop real-time polymerase chain reaction was used for validation. We also examined the serum cytokines and chemokines, such as IL-β, IL-6, TNF-α, and IP-10, and then analyzed the association of the upregulated IL-β, IL-6, TNF-α, and IP-10 with each miRNA. Results: Microarray analysis of miRNA indicated 17 upregulated miRNAs in LN patients. Such upregulation of hsa-miR-150, hsa-miR-200c, hsa-miR-l8la, hsa-miR-l25a, and hsa-miR-675 was also confirmed by RT-qPCR. We also recognized the significant upregulation of serum IL-β, IL-6, TNF-α, and IP-10 in those LN patients. Moreover, the upregulated IL-β, IL-6, and TNF-α was significantly associated with serum hsa-miR-l25a. Conclusions: Our study recognized the upregulation of miRNAs such as hsa-miR-150, hsa-miR-200c, hsa-miR-181a, hsa-miR-l25a, and hsa-miR-675 and the upregulation of such cytokines and chemokines as IL-β, IL-6, TNF-α, and IP-10. The upregulated miR-125a contributed to the upregulation of inflammatory IL-β, IL-6, and TNF-α in LN. Our findings demonstrate that miR-l25a can be a novel biomarker for SLE, and help elucidate pathogenic mechanisms of lupus nephritis.


PubMed | Renmin University of China, Inner Mongolia University and Peoples Hospital of Inner Mongolia Autonomous Region
Type: Journal Article | Journal: Molecular medicine reports | Year: 2015

Cisplatin is one of the most widely used chemotherapeutic drugs; however, the side effects and drug resistance limit its usage. Previous findings have demonstrated that cisplatin kills tumor cells through endoplasmic reticulum (ER) stress, which provides a novel method to minimize cisplatin toxicity and circumvent cisplatin resistance. ER stress induces cell autophagy, cell apoptosis and the complicated regulatory network between them. The role of autophagy in cisplatin chemotherapy remains to be elucidated. 3-Methyladenine (3-MA) is normally used as an inhibitor of autophagy. The present study reveals a significant role of the inhibition of autophagy by treatment with 3-MA and cisplatin in combination in U251 human glioma cells. It was demonstrated that cisplatin induced the ER stress associated with apoptosis and autophagy in U251 cells. Inhibition of autophagy by 3-MA increased the expression levels of protein disulfide isomerase, ubiquitinated proteins, glucose regulated protein 78 and CCAAT-enhancer-binding protein homologous protein, and induced the activation of caspase-4 and caspase-3. Treatment with 3-MA combined with cisplatin increased cisplatin-induced apoptosis by increasing ER stress. Therefore, the inhibition of autophagy has the potential to improve cisplatin chemotherapy.


Li P.,Peoples Hospital of Inner Mongolia Autonomous Region | Wu R.,Peoples Hospital of Inner Mongolia Autonomous Region
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

METHODS: Between February 2008 and June 2010, 31 cases (31 vertebrae) of osteoporotic vertebral compressive fractures were treated with PKP. Of 31 cases, 10 were male and 21 were female, aged from 64 to 80 years (mean, 70.7 years). All fractures were caused by mild trauma with an disease duration of 1-13 days. Affected vertebrae included T12 in 8 cases, L1 in 9 cases, L2 in 12 cases, and L4 in 2 cases. The effectiveness was evaluated with visual analogue scale (VAS), the Cobb's angle, and the anterior vertebral height.RESULTS: The operation was completed successfully in all cases, without serious postoperative complication. Cement leakage occurred in 11 cases (35.5%), including 3 cases at the anterior vertebral edge, 4 cases at the lateral vertebra, and 4 cases at the puncture tunnel. All the cases were followed up 6-15 months (mean, 11 months). The mean fracture healing time was 11.5 weeks (range, 8-12 weeks). VAS score was decreased from 8.1 +/- 1.2 preoperatively to 2.5 +/- 0.6 at 3 months postoperatively and to 2.3 +/- 0.8 at last follow-up; the Cobb's angle was improved from (30.2 +/- 5.3) degrees to (21.3 +/- 3.6) degrees and (23.5 +/- 3.8) degrees respectively; and the anterior vertebral height was increased from (13.98 +/- 4.62) mm to (22.03 +/- 4.93) mm and (22.56 +/- 4.34) mm respectively. There were significant differences in VAS, the Cobb's angle, and the anterior vertebral height between pre- and post-operation (P < 0.05), but there was no significant difference between 3 months postoperatively and last follow-up (P > 0.05).CONCLUSION: PKP is effective for osteoporotic vertebral compressive fractures, which can relieve pain effectively, correct kyphosis, and prevent collapse of vertebra.OBJECTIVE: To investigate the preliminary effectiveness of percutaneous kyphoplasty (PKP) in treating vertebral compressive fractures in patients with osteoporosis.


Ruijun W.,Inner Mongolia University | Shi W.,Peoples Hospital of Inner Mongolia Autonomous Region | Yijun X.,Peoples Hospital of Inner Mongolia Autonomous Region | Mengwuliji T.,Inner Mongolia University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2015

A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed of Gal (43.1%), Glu (23.6%), Ara (16.2%), Rha (9.8%) and Fru (7.3%). The results in vitro showed that 25, 50 and 100μg/mL of JRP1 could present a significant inhibition on the growth of S180 cells, and furthermore, a significant improvement on the proliferation ability of lymphocytes and the phagocytic activity of macrophages. The results in vivo showed that compared with those in the control group, the inhibition rates of different doses of JRP1 on S180 cells in the tumor-bearing mice were 35.3%, 40.6% and 48.1%, respectively, and serum immune cytokine levels such as IL-2, TNF-α and IFN-γ were significantly improved. Our results confirm that JRP1 has the activities of effective antitumor and immunomodulatory function. © 2014 Elsevier B.V.


Zhao X.,Peoples Hospital of Inner Mongolia Autonomous Region | Liu Y.,Peoples Hospital of Inner Mongolia Autonomous Region | Lusha E.,Peoples Hospital of Inner Mongolia Autonomous Region | Jiang H.,Peoples Hospital of Inner Mongolia Autonomous Region | Yu H.,Peoples Hospital of Inner Mongolia Autonomous Region
Chinese Journal of Cardiology | Year: 2015

Objective To survey the current situation of hypertension among "three minority ethnic groups" in Inner Mongolia Autonomous Region. Methods Hypertension epidemiological survey among Three Minority Ethnic Groups and Han nationality aged ≥ 18 years was performed from June to December 2010. Results The prevalence rate of hypertension among the surveyed population was 29.4% ( 630/2 146) (standardized prevalence was 34.6% ). The prevalence rate of hypertension in male was 33.8% (359/1 062) (standardized prevalence was 39.9%), and the prevalence rate in female was 25.0% (271/1 084) (standardized prevalence was 26.6% ), and the prevalence rate in male was higher than in female (P<0.01). The prevalence rate of hypertension for the Oroqen nationality, Ewenki nationality and Daur nationality was 33.8% ( 92/272 ), 32.4% ( 170/524 ), and 30.2% ( 174/576 ) respectively (standardized prevalence was 33.7% ,33.1% ,and 31.3% ) ,and which was significantly higher than in the Han nationality (25.1% ( 194/774) ,P < 0.01 ) ( standardized prevalence was 25.8% ). The awareness, treatment and control rate of hypertension in the Oroqen nationality residents was 64.1% (59/92) ,56.5% (52/92), 27.2% (25/92) ( standardized rate was 63.5% ,56.8% and 27.4% ), and 60.0% ( 102/170), 53.5% (91/170), 24.1% (41/170) (standardized rate was 62.9%, 56.7%, 26.6% ) in the Ewenki nationality residents, and 59.2% ( 103/174) ,54.0% (94/174), 20.7% (36/174) ( standardized rate was 60.3% ,54.7% ,21.4% ) in the Daur nationality residents, and 65.0% ( 126/194) ,57.7% ( 112/194), 27.3% ( 53/194 ) (standardized rate was 63.3%, 56.5%, 27.1 % ) in the Han nationality residents. Awareness rate, treatment rate and control rate were similar among different nationalities (all P > 0.05 ) . Conclusion The prevalence rate of hypertension among "three minority ethnic groups" residents in Inner Mongolia Autonomous Region is high and comprehensive prevention and therapy strategies are warranted to reduce the hypertension burden in these residents.


Ouyang Y.,Peoples Hospital of Inner Mongolia Autonomous Region | Ouyang X.-H.,Peoples Hospital of Inner Mongolia Autonomous Region | Zhang X.-J.,Peoples Hospital of Inner Mongolia Autonomous Region | Chao L.-M.,Peoples Hospital of Inner Mongolia Autonomous Region
Journal of Interventional Radiology (China) | Year: 2015

In this paper, all the intrahepatic arterioportal shunts (IHAPSs) that result from the functional redistribution of hepatic arterial and portal venous blood flow are defined as functional IHAPSs (F-IHAPSs) so as to make the differentiation from organic IHAPSs (O-IHAPSs) that result from the intrahepatic arterioportal fistula or direct communication, such as those IHAPSs that are associated with advanced hepatocellular carcinoma (HCC) and other malignant hepatic tumors as well as those IHAPSs that are accompanied by congenital hepatic vascular malformations, hereditary hemorrhagic telangioectasia (HHT) and liver trauma (including iatrogenic injury), etc. In F-IHAPSs, the most common one is formed by the compensatory (or secondary) increase of arterial blood flow that is caused by the decrease of hepatopetal portal blood flow due to a variety of reasons; its formation mechanisms can be divided into three categories: (1) trans-sinusoidal type, such as the F-IHAPSs that is associated with cirrhosis; (2) post-sinusoidal type, such as the F-IHAPSs that is accompanied with the acute stage of Budd-Chiari syndrome; and (3) pre-sinusoidal type, such as the F-IHAPSs that occurs along with the gastrointestinal hemorrhagic shock. Another kind of F-IHAPSs has been commonly seen in some hepatic diseases that have primary increase of hepatic arterial blood flow, including hypervascular hepatic cavernous hemangioma, small hepatocellular carcinoma that has rich blood supply, hepatobiliary inflammatory diseases, etc.; and in this paper they are all classified as F-IHAPSs category, however, the formation mechanisms of such F-IHAPSs vary with their basic diseases. Clinically, imaging diagnosis of F-IHAPSs can be made based on the following three signs: (1) all kinds of hepatic diseases that have concomitant intrahepatic arterioportal fistula or direct communication, as mentioned above, have been definitely excluded: (2) hepatic artery DSA reveals early visualization of portal vein in arterial phase, known as the characteristic sign of F-IHAPSs; and/or: (3) hepatic dynamic enhanced CT/MR scanning demonstrates transient enhancement of liver parenchyma in arterial phase, especially early visualization of portal vein is also present; in this case the diagnosis of F-IHAPSs can be undoubtedly confirmed. However, in making differential diagnosis, F-IHAPSs must be carefully differentiated from O-IHAPSs, local hepatic parenchymal perfusion caused by hepatic aberrant vein or by abnormal hepatopetal draining vein from systemic circulation, etc. In addition, when cirrhosis-related transient hepatic parenchymal enhancement presents as a solitary small nodule, differentiation with small HCC should be taken into consideration. In order to provide the readers with a complete and up-to-date understanding of F-IHAPSs, the relevant example illustrations, figures and graphics are accompanied with the text.


PubMed | Inner Mongolia University and Peoples Hospital of Inner Mongolia Autonomous Region
Type: | Journal: International journal of biological macromolecules | Year: 2014

A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed of Gal (43.1%), Glu (23.6%), Ara (16.2%), Rha (9.8%) and Fru (7.3%). The results in vitro showed that 25, 50 and 100 g/mL of JRP1 could present a significant inhibition on the growth of S180 cells, and furthermore, a significant improvement on the proliferation ability of lymphocytes and the phagocytic activity of macrophages. The results in vivo showed that compared with those in the control group, the inhibition rates of different doses of JRP1 on S180 cells in the tumor-bearing mice were 35.3%, 40.6% and 48.1%, respectively, and serum immune cytokine levels such as IL-2, TNF- and IFN- were significantly improved. Our results confirm that JRP1 has the activities of effective antitumor and immunomodulatory function.


PubMed | Peoples Hospital of Inner Mongolia Autonomous Region
Type: Journal Article | Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

To investigate the preliminary effectiveness of percutaneous kyphoplasty (PKP) in treating vertebral compressive fractures in patients with osteoporosis.Between February 2008 and June 2010, 31 cases (31 vertebrae) of osteoporotic vertebral compressive fractures were treated with PKP. Of 31 cases, 10 were male and 21 were female, aged from 64 to 80 years (mean, 70.7 years). All fractures were caused by mild trauma with an disease duration of 1-13 days. Affected vertebrae included T12 in 8 cases, L1 in 9 cases, L2 in 12 cases, and L4 in 2 cases. The effectiveness was evaluated with visual analogue scale (VAS), the Cobbs angle, and the anterior vertebral height.The operation was completed successfully in all cases, without serious postoperative complication. Cement leakage occurred in 11 cases (35.5%), including 3 cases at the anterior vertebral edge, 4 cases at the lateral vertebra, and 4 cases at the puncture tunnel. All the cases were followed up 6-15 months (mean, 11 months). The mean fracture healing time was 11.5 weeks (range, 8-12 weeks). VAS score was decreased from 8.1 +/- 1.2 preoperatively to 2.5 +/- 0.6 at 3 months postoperatively and to 2.3 +/- 0.8 at last follow-up; the Cobbs angle was improved from (30.2 +/- 5.3) degrees to (21.3 +/- 3.6) degrees and (23.5 +/- 3.8) degrees respectively; and the anterior vertebral height was increased from (13.98 +/- 4.62) mm to (22.03 +/- 4.93) mm and (22.56 +/- 4.34) mm respectively. There were significant differences in VAS, the Cobbs angle, and the anterior vertebral height between pre- and post-operation (P < 0.05), but there was no significant difference between 3 months postoperatively and last follow-up (P > 0.05).PKP is effective for osteoporotic vertebral compressive fractures, which can relieve pain effectively, correct kyphosis, and prevent collapse of vertebra.

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