Peoples Hospital of Inner Mongolia Autonomous Region

Wushi, China

Peoples Hospital of Inner Mongolia Autonomous Region

Wushi, China
SEARCH FILTERS
Time filter
Source Type

Li Y.,Inner Mongolia University | Liu Y.,Peoples Hospital of Inner Mongolia Autonomous Region | Guo R.,Peoples Hospital of Inner Mongolia A utonomous Region
Cancer Research and Clinic | Year: 2016

As an important incentive for cardiovascular disease, cancer, diabetes and other chronic diseases, obesity after cardiovascular disease and cancer has been listed as the third largest threat to human health by World Health Organization. Recent research has shown that obesity is associated with colorectal cancer, esophageal cancer, kidney cancer, endometrial cancer, however, it has not been fully disclosed that the mechanism could lead to an increased risk of tumors. Leptin and adiponectin are a kind of hormone secreted by adipose tissue, which involve in the energy metabolism, and play an increasing significant role in the tumors' affecting factors.


Ning C.,Inner Mongolia University | Shuyi G.,Peoples Hospital of Inner Mongolia Autonomous Region | Tao Y.,Inner Mongolia University | Hao Z.,Inner Mongolia University | Zhang X.,Inner Mongolia University
Journal of Infection and Public Health | Year: 2017

Brucellosis, a zoonosis which can seriously harm public health. Inner Mongolia is known as an endemic region of human brucellosis in China. The aim of this study is to present the epidemic of human brucellosis in Inner Mongolia from 2010 to 2014, and to provide the evidence of preventing from brucellosis in endemic areas. The study included 838,956 participants by cluster random sampling from 2010 to 2014. The contents of this study included questionnaire survey and serological testing. The seropositive rate was calculated based on the serological testing results, tested to determine whether the participants were infected by brucellosis. The new brucellosis cases were diagnosed using the questionnaire data and serological testing results then and the incidence rate was obtained. We also plotted spatial distribution maps based on the seropositive and incidence rate of human brucellosis. The total seropositive and incidence rate of human brucellosis among the high risk groups in Inner Mongolia from 2010 to 2014 was 35.91‰ and 18.25‰, respectively. The epidemic of the mid-eastern Inner Mongolia was decreased, however, the epidemic has worsened in western Inner Mongolia. Despite the epidemic of human brucellosis among the high risk groups of Inner Mongolia decreased significantly from 2010 to 2014, increased prevention and control measures are urgently needed. © 2017 The Author.


Shi Y.,Peking University | Guo S.,Peoples Hospital of Inner Mongolia Autonomous Region | Bo F.,Centers for Disease Control and Prevention | Zhang X.,Inner Mongolia Medical College | And 2 more authors.
International Journal of Infectious Diseases | Year: 2013

Objectives: The aim of this study was to evaluate the impact of HIV and sexually transmitted disease (STD) prevention interventions among female sex workers (FSWs) in the city of Hohhot in northern China. Methods: Three serial cross-sectional surveys were conducted in 2006, 2007, and 2008 among FSWs. A questionnaire was administered to the FSWs, and HIV and syphilis tests were performed for all participants. Intervention activities including condom promotion and provision, increased condom availability and accessibility, and voluntary HIV counseling and testing (VCT) were carried out among FSWs. Results: There were 624 participants in the 2006 survey, 444 in the 2007 survey, and 451 in the 2008 survey. The United Nations General Assembly Special Session (UNGASS) indicators for FSWs increased from 13.9% in 2006 to 37.7% in 2008 (p< 0.001). The average rate of consistent condom use with commercial clients in the month preceding the interview increased significantly from 39.8% in 2006 to 59.6% in 2008 (p<0.001). Not a single HIV-positive case was found among the FSWs over these 3 years, and the prevalence of syphilis decreased remarkably from 9.5% in 2006 to 1.3% in 2008. Logistic regression analysis showed that sauna or hair salon work venues, receiving services from intervention programs, and accepting HIV tests were factors associated with consistent condom use. Conclusions: The findings suggest that consistent condom use and awareness of HIV/AIDS prevention-related knowledge among FSWs have been improved by the intervention. Further prioritized and combined prevention programs aimed at FSWs are needed in order to prevent the HIV/AIDS epidemic spreading in the general population in China. © 2012 International Society for Infectious Diseases.


Wang J.,Southern Medical University | Wang J.,Peoples Hospital of Inner Mongolia Autonomous Region | Chen T.-Y.,Southern Medical University | Qin S.,Guangdong No2 Provincial Peoples Hospital | And 2 more authors.
Medical Hypotheses | Year: 2013

Diabetes and cancer are both serious health problems worldwide and can lead to a significant burden on society with high incidence. Studies show that diabetes, which may be the reason of cancer metastasis, can increase cancer incidence and mortality. Bone is one of the most preferential metastatic target sites for cancers. Studies also indicate that OPG and RANKL which regulate bone reabsorption play significant roles in the process of bone tumor metastasis. In addition, metformin as a commonly used medicine for type 2 diabetes is a negative regulator of RANKL and inhibits the differentiation of osteoclasts. We present a hypothesis that metformin serves an inhibitory effect on bone metastasis of cancer via OPG/RANKL/RANK system. © 2013 Elsevier Ltd.


Li H.,Hubei University | Li H.,Peoples Hospital of Inner Mongolia Autonomous Region | Ding G.,Hubei University
Clinical Laboratory | Year: 2016

Background: Systemic lupus erythematosus (SLE) is a clinically heterogeneous, human systemic autoimmune disease characterized by autoantibody formation. MicroRNAs (miRNA) have emerged as an important new class of modulators of gene expression and have been confirmed to regulate the lymphocyte tolerance and autoimmunity in SLE. Methods: In this study, we investigated the serum miRNA profile in lupus nephritis (LN) patients with microarray technology. TaqMan-based stem-loop real-time polymerase chain reaction was used for validation. We also examined the serum cytokines and chemokines, such as IL-β, IL-6, TNF-α, and IP-10, and then analyzed the association of the upregulated IL-β, IL-6, TNF-α, and IP-10 with each miRNA. Results: Microarray analysis of miRNA indicated 17 upregulated miRNAs in LN patients. Such upregulation of hsa-miR-150, hsa-miR-200c, hsa-miR-l8la, hsa-miR-l25a, and hsa-miR-675 was also confirmed by RT-qPCR. We also recognized the significant upregulation of serum IL-β, IL-6, TNF-α, and IP-10 in those LN patients. Moreover, the upregulated IL-β, IL-6, and TNF-α was significantly associated with serum hsa-miR-l25a. Conclusions: Our study recognized the upregulation of miRNAs such as hsa-miR-150, hsa-miR-200c, hsa-miR-181a, hsa-miR-l25a, and hsa-miR-675 and the upregulation of such cytokines and chemokines as IL-β, IL-6, TNF-α, and IP-10. The upregulated miR-125a contributed to the upregulation of inflammatory IL-β, IL-6, and TNF-α in LN. Our findings demonstrate that miR-l25a can be a novel biomarker for SLE, and help elucidate pathogenic mechanisms of lupus nephritis.


PubMed | Renmin University of China, Inner Mongolia University and Peoples Hospital of Inner Mongolia Autonomous Region
Type: Journal Article | Journal: Molecular medicine reports | Year: 2015

Cisplatin is one of the most widely used chemotherapeutic drugs; however, the side effects and drug resistance limit its usage. Previous findings have demonstrated that cisplatin kills tumor cells through endoplasmic reticulum (ER) stress, which provides a novel method to minimize cisplatin toxicity and circumvent cisplatin resistance. ER stress induces cell autophagy, cell apoptosis and the complicated regulatory network between them. The role of autophagy in cisplatin chemotherapy remains to be elucidated. 3-Methyladenine (3-MA) is normally used as an inhibitor of autophagy. The present study reveals a significant role of the inhibition of autophagy by treatment with 3-MA and cisplatin in combination in U251 human glioma cells. It was demonstrated that cisplatin induced the ER stress associated with apoptosis and autophagy in U251 cells. Inhibition of autophagy by 3-MA increased the expression levels of protein disulfide isomerase, ubiquitinated proteins, glucose regulated protein 78 and CCAAT-enhancer-binding protein homologous protein, and induced the activation of caspase-4 and caspase-3. Treatment with 3-MA combined with cisplatin increased cisplatin-induced apoptosis by increasing ER stress. Therefore, the inhibition of autophagy has the potential to improve cisplatin chemotherapy.


Li P.,Peoples Hospital of Inner Mongolia Autonomous Region | Wu R.,Peoples Hospital of Inner Mongolia Autonomous Region
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

METHODS: Between February 2008 and June 2010, 31 cases (31 vertebrae) of osteoporotic vertebral compressive fractures were treated with PKP. Of 31 cases, 10 were male and 21 were female, aged from 64 to 80 years (mean, 70.7 years). All fractures were caused by mild trauma with an disease duration of 1-13 days. Affected vertebrae included T12 in 8 cases, L1 in 9 cases, L2 in 12 cases, and L4 in 2 cases. The effectiveness was evaluated with visual analogue scale (VAS), the Cobb's angle, and the anterior vertebral height.RESULTS: The operation was completed successfully in all cases, without serious postoperative complication. Cement leakage occurred in 11 cases (35.5%), including 3 cases at the anterior vertebral edge, 4 cases at the lateral vertebra, and 4 cases at the puncture tunnel. All the cases were followed up 6-15 months (mean, 11 months). The mean fracture healing time was 11.5 weeks (range, 8-12 weeks). VAS score was decreased from 8.1 +/- 1.2 preoperatively to 2.5 +/- 0.6 at 3 months postoperatively and to 2.3 +/- 0.8 at last follow-up; the Cobb's angle was improved from (30.2 +/- 5.3) degrees to (21.3 +/- 3.6) degrees and (23.5 +/- 3.8) degrees respectively; and the anterior vertebral height was increased from (13.98 +/- 4.62) mm to (22.03 +/- 4.93) mm and (22.56 +/- 4.34) mm respectively. There were significant differences in VAS, the Cobb's angle, and the anterior vertebral height between pre- and post-operation (P < 0.05), but there was no significant difference between 3 months postoperatively and last follow-up (P > 0.05).CONCLUSION: PKP is effective for osteoporotic vertebral compressive fractures, which can relieve pain effectively, correct kyphosis, and prevent collapse of vertebra.OBJECTIVE: To investigate the preliminary effectiveness of percutaneous kyphoplasty (PKP) in treating vertebral compressive fractures in patients with osteoporosis.


Ruijun W.,Inner Mongolia University | Shi W.,Peoples Hospital of Inner Mongolia Autonomous Region | Yijun X.,Peoples Hospital of Inner Mongolia Autonomous Region | Mengwuliji T.,Inner Mongolia University | And 2 more authors.
International Journal of Biological Macromolecules | Year: 2015

A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed of Gal (43.1%), Glu (23.6%), Ara (16.2%), Rha (9.8%) and Fru (7.3%). The results in vitro showed that 25, 50 and 100μg/mL of JRP1 could present a significant inhibition on the growth of S180 cells, and furthermore, a significant improvement on the proliferation ability of lymphocytes and the phagocytic activity of macrophages. The results in vivo showed that compared with those in the control group, the inhibition rates of different doses of JRP1 on S180 cells in the tumor-bearing mice were 35.3%, 40.6% and 48.1%, respectively, and serum immune cytokine levels such as IL-2, TNF-α and IFN-γ were significantly improved. Our results confirm that JRP1 has the activities of effective antitumor and immunomodulatory function. © 2014 Elsevier B.V.


PubMed | Inner Mongolia University and Peoples Hospital of Inner Mongolia Autonomous Region
Type: | Journal: International journal of biological macromolecules | Year: 2014

A water-soluble polysaccharide, named as JRP1, was extracted and fractioned from the epicarp of immature fruit of Juglans mandshurica Maxim. The determination of the monosaccharide composition in JRP1 with gas chromatography (GC) showed that JRP1 was composed of Gal (43.1%), Glu (23.6%), Ara (16.2%), Rha (9.8%) and Fru (7.3%). The results in vitro showed that 25, 50 and 100 g/mL of JRP1 could present a significant inhibition on the growth of S180 cells, and furthermore, a significant improvement on the proliferation ability of lymphocytes and the phagocytic activity of macrophages. The results in vivo showed that compared with those in the control group, the inhibition rates of different doses of JRP1 on S180 cells in the tumor-bearing mice were 35.3%, 40.6% and 48.1%, respectively, and serum immune cytokine levels such as IL-2, TNF- and IFN- were significantly improved. Our results confirm that JRP1 has the activities of effective antitumor and immunomodulatory function.


PubMed | Peoples Hospital of Inner Mongolia Autonomous Region
Type: Journal Article | Journal: Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | Year: 2012

To investigate the preliminary effectiveness of percutaneous kyphoplasty (PKP) in treating vertebral compressive fractures in patients with osteoporosis.Between February 2008 and June 2010, 31 cases (31 vertebrae) of osteoporotic vertebral compressive fractures were treated with PKP. Of 31 cases, 10 were male and 21 were female, aged from 64 to 80 years (mean, 70.7 years). All fractures were caused by mild trauma with an disease duration of 1-13 days. Affected vertebrae included T12 in 8 cases, L1 in 9 cases, L2 in 12 cases, and L4 in 2 cases. The effectiveness was evaluated with visual analogue scale (VAS), the Cobbs angle, and the anterior vertebral height.The operation was completed successfully in all cases, without serious postoperative complication. Cement leakage occurred in 11 cases (35.5%), including 3 cases at the anterior vertebral edge, 4 cases at the lateral vertebra, and 4 cases at the puncture tunnel. All the cases were followed up 6-15 months (mean, 11 months). The mean fracture healing time was 11.5 weeks (range, 8-12 weeks). VAS score was decreased from 8.1 +/- 1.2 preoperatively to 2.5 +/- 0.6 at 3 months postoperatively and to 2.3 +/- 0.8 at last follow-up; the Cobbs angle was improved from (30.2 +/- 5.3) degrees to (21.3 +/- 3.6) degrees and (23.5 +/- 3.8) degrees respectively; and the anterior vertebral height was increased from (13.98 +/- 4.62) mm to (22.03 +/- 4.93) mm and (22.56 +/- 4.34) mm respectively. There were significant differences in VAS, the Cobbs angle, and the anterior vertebral height between pre- and post-operation (P < 0.05), but there was no significant difference between 3 months postoperatively and last follow-up (P > 0.05).PKP is effective for osteoporotic vertebral compressive fractures, which can relieve pain effectively, correct kyphosis, and prevent collapse of vertebra.

Loading Peoples Hospital of Inner Mongolia Autonomous Region collaborators
Loading Peoples Hospital of Inner Mongolia Autonomous Region collaborators