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Chang P.Y.,Inner Mongolia University | Qin L.,Inner Mongolia University | Zhao P.,Inner Mongolia Autonomous Region Peoples Hospital | Liu Z.Y.,Inner Mongolia University
Genetics and Molecular Research | Year: 2015

Genetic variants of the RGS5 gene are believed to be risk factors for hypertension and cardiovascular diseases. In this study, we investigated the association between RGS5 gene variants and hypertension in the Mongolian and Han populations. Peripheral blood was obtained from 429 unrelated Mongolian herdsmen and 416 Han farmers [including essential hypertension (EH) patients and controls]. Nine tagSNPs within the RGS5 genes were retrieved from HapMap, and the samples were individually genotyped using the polymerase chain reaction/ligase detection reaction assay. The distribution of the allele frequency of rs12035879 differed significantly between hypertensive subjects and controls in the Han population, while the distribution of the allele and genotype frequencies of rs16849802 differed significantly between hypertensive subjects and controls in the Mongolian population. We observed an association between rs16849802 and EH in the Mongolian population. The frequency of haplotype GAA was significantly higher in the EH group than in controls in the Mongolian population. However, the EH group and controls did not differ significantly in all 6 haplotypes in the Han population. The rs16849802 and haplotype GAA independently increased the risk of EH in Mongolian patients, and may be used as a risk factor for the prediction of high blood pressure. © FUNPEC-RP.

Kong D.-M.,Inner Mongolia Medical College | Cui W.,Inner Mongolia Autonomous Region Peoples Hospital
International Journal of Ophthalmology | Year: 2011

Neovascular glaucoma (NVG) is a kind of eye disease with strong destroy and high blindness rate. Extensive retinal ischemia is the main reason and there is lack of the effective treatment. Early diagnosis and effective treatment is the most important to control the intraocular pressure and maintain good vision. We will present the NVG treatment situation and future development trend in this paper.

Peng J.,Shanghai JiaoTong University | Ma J.,Shanghai JiaoTong University | Li W.,Shanghai JiaoTong University | Mo R.,Inner Mongolia Autonomous Region Peoples Hospital | And 6 more authors.
Cancer Letters | Year: 2015

Characterization of the exome and genome of carcinoma (ccRCC) by next-generation sequencing identified numerous genetic alternations. BRCA1-associated protein-1 (BAP1) was identified as one of the most frequently mutated genes in ccRCC, suggesting that BAP1 is a potential key driver for ccRCC cancer initiation and progression. However, how BAP1 mutations contribute to ccRCC remains to be elucidated. BAP1 is a nuclear de-ubiquitinating enzyme and cleaves the ubiquitin chain from the substrates. Here, we identified MCRS1 as a bona fide substrate for BAP1. MCRS1 is a component of the centrosome proteins, and plays an essential role in spindle assembly. BAP1 binds to MCRS1 and stabilizes MCRS1 by de-ubiquitination. BAP1 contributes to chromosome stability partially via MCRS1. A positive correlation was identified between BAP1 and MCRS1 expression in ccRCC tissues. Both BAP1 loss and MCRS1 down-regulation in ccRCC were associated with adverse clinicopathological features. This study revealed a novel mechanism for BAP1 involved in MCRS1 stability regulation, and provided insight in understanding the relationship between BAP1 mutations and chromosome instability in ccRCC. © 2015 Elsevier Ireland Ltd.

Wu B.,Inner Mongolia University | Gao W.,Inner Mongolia Autonomous Region Peoples Hospital | Cui W.,Inner Mongolia Autonomous Region Peoples Hospital
International Eye Science | Year: 2013

Security and perfect vision and fewer complications are our goals in cataract surgery, and hard-nucleus cataract surgery is always a difficulty one. Many new studies indicate that micro-incision phacoemulsification in treating hard nucleus cataract is obviously effective. This article reviews the evolution process of hard nuclear cataract surgery, the new progress in the research of artificial intraocular lens for microincision, and analyse advantages and disadvantages of various surgical methods.

Liu J.-Z.,Inner Mongolia University | Gao W.,Inner Mongolia Autonomous Region Peoples Hospital | Cui W.,Inner Mongolia Autonomous Region Peoples Hospital
International Eye Science | Year: 2014

Micro-incision coaxial phacoemulsification is a new operation carried out in recent years. Compared with conventional incision phacoemulsification, micro-incision coaxial phacoemulsification has the advantages of smaller incision, less tissue damage, faster visual outcomes. The article summarizes the effects of micro-incision coaxial phacoemulsification on corneal incision change, astigmatism change, corneal endothelial injury, anterior chamber stability, and intraocular lens implantation by reference to the literature in recent years.

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