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D'souza M.M.,INMAS | Choudhary A.,RML Hospital | Poonia M.,INMAS | Kumar P.,INMAS | Khushu S.,INMAS
Injury | Year: 2017

Background The ability of diffusion tensor imaging (DTI) to complement conventional MR imaging by diagnosing subtle injuries to the spinal cord is a subject of intense research. We attempted to study change in the DTI indices, namely fractional anisotropy (FA) and mean diffusivity (MD) after traumatic cervical spinal cord injury and compared these with corresponding data from a control group of individuals with no injury. The correlation of these quantitative indices to the neurological profile of the patients was assessed. Material and methods 20 cases of acute cervical trauma and 30 age and sex matched healthy controls were enrolled. Scoring of extent of clinical severity was done based on the Frankel grading system. MRI was performed on a 3T system. Following the qualitative tractographic evaluation of white matter tracts, quantitative datametrics were calculated. Results In patients, the Mean FA value at the level of injury (0.43+/−0.08) was less than in controls (0.62+/−0.06), which was statistically significant (p value <0.001). Further, the Mean MD value at the level of injury (1.30+/−0.24) in cases was higher than in controls (1.07+/−0.12, p value <0.001). Statistically significant positive correlation was found between clinical grading (Frankel grade) and FA values at the level of injury (r value = 0.86). Negative correlation was found between clinical grade and Mean MD at the level of injury (r value = −0.38) which was however statistically not significant. Conclusion Quantitative DTI indices are a useful parameter for detection of spinal cord injury. FA value was significantly decreased while MD value was significantly increased at the level of injury in cases as compared to controls. Further, FA showed significant correlation with clinical grade. DTI could thus serve as a reliable objective imaging tool for assessment of white matter integrity and prognostication of functional outcome. © 2017 Elsevier Ltd

Kakkar V.,Panjab University | Mishra A.K.,INMAS | Chuttani K.,INMAS | Kaur I.P.,Panjab University
International Journal of Pharmaceutics | Year: 2013

Having achieved a significant bioavailability of curcumin by its incorporation into SLNs (C-SLNs) during pharmacokinetic (32-155 times) and pharmacodynamic (3-4 times) studies, our intent was to proof their targeting to brain. Hence, fluorescent/confocal microscopy, biodistribution and gamma scintigraphy techniques were explored to observe the presence of C-SLNs in the brain. 1 h post p.o administration of C-SLNs/free curcumin (C-S) to rats, blood was withdrawn, following which the animals were sacrificed and their harvested brains were frozen at -80 C. The obtained plasma and brain cryosections were observed for fluorescence under fluorescent/confocal microscope. Biodistribution study was performed using 99mTc-labeled C-SLNs and C-S in Balb/c mice after p.o. and i.v. administration and % radioactivity/g organ was recorded. Subsequent to this gamma scintigraphs of the New Zealand rabbits following similar treatments were performed. Presence of yellow fluorescent particles in plasma and brain indicated effective delivery of C-SLNs across the gut wall and the BBB. BloodAUCoral value for C-SLNs was 8.135 times greater than that for C-S, confirming a prolonged circulation of former. The ratio of blood AUCi.v. C-SLN/C-S in blood is ≤1 while the ratio in brain promisingly indicates 30 times higher preferential distribution of C-SLNs into brain confirming their direct delivery. © 2013 Elsevier B.V. All rights reserved.

Baloda V.,Institute of Nuclear Medicine and Allied Sciences | Choudhary A.,Institute of Nuclear Medicine and Allied Sciences | Chugh P.,Institute of Nuclear Medicine and Allied Sciences | Aggarwal R.,INMAS
Journal of Clinical and Diagnostic Research | Year: 2017

Thyroid tuberculosis is uncommon even in countries like India where prevalence of tuberculosis is high. Bactericidal actions of colloid, excess iodine stores and high vascularity of the gland have been implicated for the very rare occurrence of thyroid tuberculosis. We present a case of a 16-year-old male with thyroid involvement as a part of disseminated tuberculosis. The clinical presentation of thyroid tuberculosis is varied and may be missed if not kept in the differential diagnosis of goitre. This case also highlights the role of fine needle aspiration cytology in management of goitre. It is an important diagnostic test as it avoids unnecessary surgical intervention. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

Sindhu R.,Jamia Millia Islamia University | Tiwari A.K.,INMAS | Mishra L.C.,University of Delhi | Husain M.M.,Jamia Millia Islamia University
Cancer Biotherapy and Radiopharmaceuticals | Year: 2012

The absorption and fluorescence spectra of the 7-diethylamino-4-methyl coumarin (DAMC) in ethanol-water (1:9 v/v) solution at varying pH values were investigated. The interaction between DAMC and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy. The Stern-Volmer quenching constant, the quenching rate constant of the bimolecular reaction (kq), the binding constant, and number of binding sites are mentioned but not calculated in the paper. Moreover, in a preliminary pharmacological study, DAMC not only remarkably increased cellular apoptosis in a concentration-dependent manner but also clearly induced A549 cell cycle arrest. Thus, these coumarin derivatives merit investigation as novel potential antitumor agents with further structural modification to produce an optimal lead compound and elucidate the detailed pharmacological mechanism. © 2012 Mary Ann Liebert, Inc.

PubMed | Panjab University, Banasthali University, INMAS and Government Ayurvedic College
Type: | Journal: Journal of ethnopharmacology | Year: 2016

The genus Anogeissus (axlewood tree, ghatti tree, button tree and chewing stick tree) belongs to Combretaceae, includes eight species that are distributed in Asia and Africa. Plants are used as an ethnomedicine in Asia and Africa to treat various ailments like diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Based on the traditional knowledge, different phytochemical and pharmacological activities have been at the focus of research. The aim of this review is to provide updated, comprehensive and categorized information on the ethnobotany, phytochemistry, pharmacological research and toxicity of Anogeissus species in order to identify their therapeutic potential and directs future research opportunities.The relevant data was searched by using the keyword Anogeissus in Scopus, Google Scholar, Web of Science, PubMed, and ScienceDirect databases. Plant taxonomy was validated by the databases The Plant List and A.J. Scott, 1979.This review discusses the current knowledge of the ethnobotany, phytochemistry and in vitro as well as in vivo pharmacological evaluations carried out on the extracts and isolated main active constituents of Anogeissus genus. Among eight species, most of the phytochemical and pharmacological studies were performed on four species. About 55 secondary metabolites are isolated from the genus. Stem bark, leaf, seed, fruit, root of the plants are used for the treatment of several health disorders such as diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Gum ghatti obtained from Anogeissus latifolia is used after delivery as tonic and in spermatorrhoea. Many phytochemical investigations on this genus confirmed that it is rich in phenolic compounds. Modern pharmacology research has confirmed that the crude extracts or the isolated active compounds of the genus Anogeissus possess antioxidant, antimicrobial, wound healing, antiulcer, anti-inflammation, anti-diabetics, hepatoprotective, hypolipidemic, antiparasitic and neuroprotective effects.This review confirms that some Anogeissus species have emerged as a good source of the traditional medicine for wound healing, inflammation, skin diseases, microbial infection and diabetes. Many traditional uses of Anogeissus species have now been validated by modern pharmacology research. Intensive investigations of all the species of Anogeissus regarding phytochemical and pharmacological properties, especially their mechanism of action, safety and efficacy could be the future research interests before starting clinical trials.

Patra S.,Kalawati Saran Childrens Hospital | Singh V.,Kalawati Saran Childrens Hospital | Chandra J.,Kalawati Saran Childrens Hospital | Kumar P.,Kalawati Saran Childrens Hospital | Tripathi M.,INMAS
Journal of Tropical Pediatrics | Year: 2011

Objective: To compare the diagnostic value of Gastro-intestinal (GI) scintiscan with 24-h pH study in detecting gastro-esophageal reflux (GER) among infantile wheezers. Subjects: Fifty-two children <2 years of age. Methods: All patients, irrespective of symptom underwent study to evaluate for GER. Results: GER studies were positive in almost 45% of cases. The agreement between positivity of these two tests is best among children between 7 and 12 months of age (κ = 0.591, p = 0.002). Overall GI scintiscan was a better test with higher sensitivity and specificity as compared to 24-h pH study when compared with the history suggestive of reflux and clinical response with anti-reflux treatment as standard (p ≤ .001). Conclusion: Both GER scan and 24-h pH study are complimentary to each other, however, if both the tests are available then GI scintiscan is better as a single test for GER in these early wheezers. © The Author [2010]. Published by Oxford University Press. All rights reserved.

Arora S.,Netaji Subhas Institute of Technology | Chandel S.S.,Deen Dayal Upadhyay Gorakhpur University | Chandra S.,INMAS
2014 International Conference on the IMpact of E-Technology on US, IMPETUS 2014 | Year: 2014

This paper presents a fusion approach called Image and Signal Analysis of Multimedia Content (ISAMC) to provide a fully evolved model for emotion recognition using both external (face) and internal (EEG signals) characteristics for the same emotional phenomenon. Both image analysis and EEG signal analysis is done using a video stimulus and based on wavelet approach for feature extraction. This novel methodology provides cross-validation of EEG and Image results with self-assessment of the participants and encourages multi-classification with the use of two different classifiers. The encouraging experimental results prove that the efficiency of this method is very high and due to its simplicity it can be a promising tool for emotion recognition. © 2014 PES Institute of Technology, Bangalore.

Saini M.K.,University of Delhi | Gupta R.,University of Delhi | Parbhakar S.,University of Delhi | Kumar Mishra A.,INMAS | And 2 more authors.
RSC Advances | Year: 2014

A series of rare-earth substituted dimeric complexes of Keggin-type silicotungstates: [{Ln(α-SiW11O39)(H 2O)}2(μ-CH3COO)2]12- [Ln = EuIII (Eu-1), GdIII (Gd-2), TbIII (Tb-3), DyIII (Dy-4), HoIII (Ho-5), ErIII (Er-6) and TmIII (Tm-7)] and [Ln(α-SiW11O39) 2]13- [Ln = PrIII (Pr-8), NdIII (Nd-9), SmIII (Sm-10)] were synthesized by a single step reaction of Na10[α-SiW9O34]·16H2O with Ln(NO3)3·nH2O in potassium acetate buffer at pH 4.5. All these compounds were structurally characterized by single-crystal X-ray diffraction, and other analytical techniques including FT-IR, ICP-AES, UV/vis, photoluminescence spectroscopy, thermogravimetric analysis, 13C and 1H NMR spectroscopy and vibrating sample magnetometry (VSM). The single-crystal X-ray diffraction and FT-IR studies suggest that the compounds Na4K8[{Ln(α-SiW 11O39)(H2O)}2(μ-CH3COO) 2]·xH2O (Ln = Eu - Tm) (Eu-1a-Tm-7a), and K 6Na7[Ln(SiW11O39) 2]·xH2O (Ln = Pr, Nd, Sm) (Pr-8a-Sm-10a) are isostructural. The photoluminescence properties of Eu-1a, Tb-3a, Dy-4a and Sm-10a were studied at room temperature. VSM studies of Gd-2a, Tb-3a, Dy-4a, Ho-5a, Er-6a and Tm-7a were carried out at room temperature, and they showed paramagnetic behaviour. © 2014 the Partner Organisations.

Patra S.,Kalawati Saran Childrens Hospital | Singh V.,Kalawati Saran Childrens Hospital | Chandra J.,Kalawati Saran Childrens Hospital | Kumar P.,Kalawati Saran Childrens Hospital | Tripathi M.,INMAS
Pediatric Pulmonology | Year: 2011

Wheezing is common among infants and young children due to peculiar anatomical and physiological properties of their lungs. Gastro-oesophageal reflux (GER) has been incriminated as one of the cause of non-asthmatic wheezing in this age group. The present study evaluates the magnitude of GER and its causal relationship with wheezing in early childhood. All recurrent and persistent wheezers (under two years) were investigated for GER and treated medically where tests were positive. The subjects were further profiled to identify any predictors for GER. Sixty-seven children of less than 2 years age with recurrent or persistent wheezing were evaluated for GER. Mean age of the study subjects at enrolment was 10.8 months and at onset of wheezing was 7.1 (±3.8S.D) months. Asthma and wheeze associated lower respiratory tract infection (WALRI) was diagnosed in about 1/3 each of the patients studied. GER studies were positive in over one-third (25/67) of cases. Forty-two percent of children who wheezed by 1 year of age had a positive GER study. Interestingly, nearly half (12/25) of the patients with an abnormal study did not have any clinical suggestion of regurgitation ("silent" GERs). The severity of wheezing was higher among those who had GER versus those who did not (p≤0.048; OR: 3.2). However, only 32% patients showed significant response to anti reflux treatment alone while others had partial response. GER, therefore, is an important cause for recurrent wheezing among children less than 2 years of age, either singularly or as a co-morbidity. The study findings justify investigations for GER among early wheezers; particularly for those who have onset of symptoms by 12 months of age or those who have severe disease. © 2010 Wiley-Liss, Inc.

Bhandari S.K.,CMDC Science | Mondal A.,INMAS
Medical Journal Armed Forces India | Year: 2016

Background: A study of first indigenous titanium dental implant developed by DRDO was undertaken at INMAS, Delhi. The aim was to establish the time taken for osseointegration, along with objectives to define the time of implant loading and compare the osseointegra- tion of indigenous dental implants with already established dental implant systems. Methods: 21 subjects rehabilitated using 39 indigenous dental implants were evaluated by bone SPECT before implantation and at regular intervals towards establishing the aim and objectives. Results: The rise followed by fall in Osteoblastic activity indicates the postoperative physiologic changes, which peaked at 2 weeks (mean) post-implantation and falls off to preimplantation levels in 12 weeks (mean) indicating completion of osseointegration, healing and time of loading. Conclusion: It can be summarized that the Osteoblastic activity of indigenous dental implants completes within three months, which can be taken as the time required for complete healing/osseointegration and loading the implants. On comparison with the available data of already established implants the figures appear similar, indicating indigenous implants to be similar in biologic behaviour. © 2012 Published by Elsevier B.V. on behalf of Director General, Armed Forces Medical Services.

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