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Sindhu R.,Jamia Millia Islamia University | Tiwari A.K.,INMAS | Mishra L.C.,University of Delhi | Husain M.M.,Jamia Millia Islamia University
Cancer Biotherapy and Radiopharmaceuticals | Year: 2012

The absorption and fluorescence spectra of the 7-diethylamino-4-methyl coumarin (DAMC) in ethanol-water (1:9 v/v) solution at varying pH values were investigated. The interaction between DAMC and bovine serum albumin (BSA) was investigated by fluorescence spectroscopy. The Stern-Volmer quenching constant, the quenching rate constant of the bimolecular reaction (kq), the binding constant, and number of binding sites are mentioned but not calculated in the paper. Moreover, in a preliminary pharmacological study, DAMC not only remarkably increased cellular apoptosis in a concentration-dependent manner but also clearly induced A549 cell cycle arrest. Thus, these coumarin derivatives merit investigation as novel potential antitumor agents with further structural modification to produce an optimal lead compound and elucidate the detailed pharmacological mechanism. © 2012 Mary Ann Liebert, Inc.


PubMed | Panjab University, Banasthali University, INMAS and Government Ayurvedic College
Type: | Journal: Journal of ethnopharmacology | Year: 2016

The genus Anogeissus (axlewood tree, ghatti tree, button tree and chewing stick tree) belongs to Combretaceae, includes eight species that are distributed in Asia and Africa. Plants are used as an ethnomedicine in Asia and Africa to treat various ailments like diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Based on the traditional knowledge, different phytochemical and pharmacological activities have been at the focus of research. The aim of this review is to provide updated, comprehensive and categorized information on the ethnobotany, phytochemistry, pharmacological research and toxicity of Anogeissus species in order to identify their therapeutic potential and directs future research opportunities.The relevant data was searched by using the keyword Anogeissus in Scopus, Google Scholar, Web of Science, PubMed, and ScienceDirect databases. Plant taxonomy was validated by the databases The Plant List and A.J. Scott, 1979.This review discusses the current knowledge of the ethnobotany, phytochemistry and in vitro as well as in vivo pharmacological evaluations carried out on the extracts and isolated main active constituents of Anogeissus genus. Among eight species, most of the phytochemical and pharmacological studies were performed on four species. About 55 secondary metabolites are isolated from the genus. Stem bark, leaf, seed, fruit, root of the plants are used for the treatment of several health disorders such as diabetes, fever, diarrhoea, dysentery, tuberculosis, wound healing, skin diseases (eczema, psoriasis), snake and scorpion venom. Gum ghatti obtained from Anogeissus latifolia is used after delivery as tonic and in spermatorrhoea. Many phytochemical investigations on this genus confirmed that it is rich in phenolic compounds. Modern pharmacology research has confirmed that the crude extracts or the isolated active compounds of the genus Anogeissus possess antioxidant, antimicrobial, wound healing, antiulcer, anti-inflammation, anti-diabetics, hepatoprotective, hypolipidemic, antiparasitic and neuroprotective effects.This review confirms that some Anogeissus species have emerged as a good source of the traditional medicine for wound healing, inflammation, skin diseases, microbial infection and diabetes. Many traditional uses of Anogeissus species have now been validated by modern pharmacology research. Intensive investigations of all the species of Anogeissus regarding phytochemical and pharmacological properties, especially their mechanism of action, safety and efficacy could be the future research interests before starting clinical trials.


Patra S.,Kalawati Saran Childrens Hospital | Singh V.,Kalawati Saran Childrens Hospital | Chandra J.,Kalawati Saran Childrens Hospital | Kumar P.,Kalawati Saran Childrens Hospital | Tripathi M.,INMAS
Journal of Tropical Pediatrics | Year: 2011

Objective: To compare the diagnostic value of Gastro-intestinal (GI) scintiscan with 24-h pH study in detecting gastro-esophageal reflux (GER) among infantile wheezers. Subjects: Fifty-two children <2 years of age. Methods: All patients, irrespective of symptom underwent study to evaluate for GER. Results: GER studies were positive in almost 45% of cases. The agreement between positivity of these two tests is best among children between 7 and 12 months of age (κ = 0.591, p = 0.002). Overall GI scintiscan was a better test with higher sensitivity and specificity as compared to 24-h pH study when compared with the history suggestive of reflux and clinical response with anti-reflux treatment as standard (p ≤ .001). Conclusion: Both GER scan and 24-h pH study are complimentary to each other, however, if both the tests are available then GI scintiscan is better as a single test for GER in these early wheezers. © The Author [2010]. Published by Oxford University Press. All rights reserved.


Arora S.,Netaji Subhas Institute of Technology | Chandel S.S.,Deen Dayal Upadhyay Gorakhpur University | Chandra S.,INMAS
2014 International Conference on the IMpact of E-Technology on US, IMPETUS 2014 | Year: 2014

This paper presents a fusion approach called Image and Signal Analysis of Multimedia Content (ISAMC) to provide a fully evolved model for emotion recognition using both external (face) and internal (EEG signals) characteristics for the same emotional phenomenon. Both image analysis and EEG signal analysis is done using a video stimulus and based on wavelet approach for feature extraction. This novel methodology provides cross-validation of EEG and Image results with self-assessment of the participants and encourages multi-classification with the use of two different classifiers. The encouraging experimental results prove that the efficiency of this method is very high and due to its simplicity it can be a promising tool for emotion recognition. © 2014 PES Institute of Technology, Bangalore.


Sareen A.,Lady Hardinge Medical College | D'souza M.M.,INMAS | Reddy K.B.,Lady Hardinge Medical College | Kanojia R.K.,Lady Hardinge Medical College | Kumar A.,Lady Hardinge Medical College and Associated Kalawati Saran Children Hospital
American Journal of Medical Genetics, Part A | Year: 2015

Genochondromatosis is an extremely rare autosomal dominant disorder, which manifests during childhood and tends to regress in adult life. The bony lesions are symmetrically distributed with characteristic localization at the metaphysis of proximal humerus and distal femur. Two types have been described based on the involvement of clavicle. Usually asymptomatic, sometimes patients may present with pathological fractures. In this communication, we describe four members of a family with Genochondromatosis type I, with some additional clinical and radiological findings not reported previously. © 2015 Wiley Periodicals, Inc.


Saini M.K.,University of Delhi | Gupta R.,University of Delhi | Parbhakar S.,University of Delhi | Kumar Mishra A.,INMAS | And 2 more authors.
RSC Advances | Year: 2014

A series of rare-earth substituted dimeric complexes of Keggin-type silicotungstates: [{Ln(α-SiW11O39)(H 2O)}2(μ-CH3COO)2]12- [Ln = EuIII (Eu-1), GdIII (Gd-2), TbIII (Tb-3), DyIII (Dy-4), HoIII (Ho-5), ErIII (Er-6) and TmIII (Tm-7)] and [Ln(α-SiW11O39) 2]13- [Ln = PrIII (Pr-8), NdIII (Nd-9), SmIII (Sm-10)] were synthesized by a single step reaction of Na10[α-SiW9O34]·16H2O with Ln(NO3)3·nH2O in potassium acetate buffer at pH 4.5. All these compounds were structurally characterized by single-crystal X-ray diffraction, and other analytical techniques including FT-IR, ICP-AES, UV/vis, photoluminescence spectroscopy, thermogravimetric analysis, 13C and 1H NMR spectroscopy and vibrating sample magnetometry (VSM). The single-crystal X-ray diffraction and FT-IR studies suggest that the compounds Na4K8[{Ln(α-SiW 11O39)(H2O)}2(μ-CH3COO) 2]·xH2O (Ln = Eu - Tm) (Eu-1a-Tm-7a), and K 6Na7[Ln(SiW11O39) 2]·xH2O (Ln = Pr, Nd, Sm) (Pr-8a-Sm-10a) are isostructural. The photoluminescence properties of Eu-1a, Tb-3a, Dy-4a and Sm-10a were studied at room temperature. VSM studies of Gd-2a, Tb-3a, Dy-4a, Ho-5a, Er-6a and Tm-7a were carried out at room temperature, and they showed paramagnetic behaviour. © 2014 the Partner Organisations.


Patra S.,Kalawati Saran Childrens Hospital | Singh V.,Kalawati Saran Childrens Hospital | Chandra J.,Kalawati Saran Childrens Hospital | Kumar P.,Kalawati Saran Childrens Hospital | Tripathi M.,INMAS
Pediatric Pulmonology | Year: 2011

Wheezing is common among infants and young children due to peculiar anatomical and physiological properties of their lungs. Gastro-oesophageal reflux (GER) has been incriminated as one of the cause of non-asthmatic wheezing in this age group. The present study evaluates the magnitude of GER and its causal relationship with wheezing in early childhood. All recurrent and persistent wheezers (under two years) were investigated for GER and treated medically where tests were positive. The subjects were further profiled to identify any predictors for GER. Sixty-seven children of less than 2 years age with recurrent or persistent wheezing were evaluated for GER. Mean age of the study subjects at enrolment was 10.8 months and at onset of wheezing was 7.1 (±3.8S.D) months. Asthma and wheeze associated lower respiratory tract infection (WALRI) was diagnosed in about 1/3 each of the patients studied. GER studies were positive in over one-third (25/67) of cases. Forty-two percent of children who wheezed by 1 year of age had a positive GER study. Interestingly, nearly half (12/25) of the patients with an abnormal study did not have any clinical suggestion of regurgitation ("silent" GERs). The severity of wheezing was higher among those who had GER versus those who did not (p≤0.048; OR: 3.2). However, only 32% patients showed significant response to anti reflux treatment alone while others had partial response. GER, therefore, is an important cause for recurrent wheezing among children less than 2 years of age, either singularly or as a co-morbidity. The study findings justify investigations for GER among early wheezers; particularly for those who have onset of symptoms by 12 months of age or those who have severe disease. © 2010 Wiley-Liss, Inc.


Bhandari S.K.,CMDC Science | Mondal A.,INMAS
Medical Journal Armed Forces India | Year: 2016

Background: A study of first indigenous titanium dental implant developed by DRDO was undertaken at INMAS, Delhi. The aim was to establish the time taken for osseointegration, along with objectives to define the time of implant loading and compare the osseointegra- tion of indigenous dental implants with already established dental implant systems. Methods: 21 subjects rehabilitated using 39 indigenous dental implants were evaluated by bone SPECT before implantation and at regular intervals towards establishing the aim and objectives. Results: The rise followed by fall in Osteoblastic activity indicates the postoperative physiologic changes, which peaked at 2 weeks (mean) post-implantation and falls off to preimplantation levels in 12 weeks (mean) indicating completion of osseointegration, healing and time of loading. Conclusion: It can be summarized that the Osteoblastic activity of indigenous dental implants completes within three months, which can be taken as the time required for complete healing/osseointegration and loading the implants. On comparison with the available data of already established implants the figures appear similar, indicating indigenous implants to be similar in biologic behaviour. © 2012 Published by Elsevier B.V. on behalf of Director General, Armed Forces Medical Services.


Jain A.K.,GTB Hospital | Srivastava A.,GTB Hospital | Saini N.S.,INMAS | Dhammi I.K.,GTB Hospital | And 2 more authors.
Indian Journal of Orthopaedics | Year: 2012

Background: Duration of treatment in tuberculosis of spine has always been debatable in the absence of marker of healing. The objective of the study was to evaluate the efficacy of extended DOTS regimen (2 months of intensive phase and 6 months of continuation phase) as recommended by WHO, by using MRI observations as the healing marker. Materials and Methods: 51 (Group A-28 prospective and Group B-23 retrospective) patients of spine TB with mean age of 26.8 years (range 15-54 years) diagnosed clinico radiologically/imaging (n=36), histopathology or by PCR (n=15) were enrolled for the study. They were treated by extended DOTS regimen (2 months of HRZE and 6 months of HR) administered alternate day. The serial blood investigations and X-rays were done every 2 months. Contrast MRI was done at the end of 8 months and healing changes were recorded. Criteria of healing on the basis of MRI being: complete resolution of pre and paravertebral collections, resolution of marrow edema of vertebral body (VB), replacement of marrow edema by fat or by calcification suggested by iso-intense T1 and T2 weighted images in contrast enhanced MRI. Patients with non healed status, but, responding lesion on MRI after 8 months of treatment were continued on INH and rifampicin alternate day and contrast MRI was done subsequently at 12 months and 18 months till the healed status was achieved. Results: 9 patients had paraplegia and required surgical intervention out of which 1 did not recover neurologically. All patients have completed 8 months of extended DOTS regimen, n=18 achieved healed status and duration of treatment was extended in rest (n=33) 5 were declared healed after 12 months, 8 after 18 months and one after 36 months of treatment, thus 32 were declared healed at varying periods. Conclusion: 35.2% patients demonstrate MRI based healed vertebral lesion at the end of 8 months of extended category 1 DOTS regimen. It is unscientific to stop the ATT by fixed time frame and MRI evaluation of the patients is required after 8 months of ATT and subsequently to decide for the continuation stoppage of treatment.


PubMed | INMAS
Type: Journal Article | Journal: Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India | Year: 2014

Hemichorea and generalized chorea are rare syndromes associated with nonketotic hyperglycemia. This disorder usually afflicts elderly females, and may herald the onset of new onset diabetes, usually type 2. There are conflicting reports of the underlying pathophysiology of this rare entity. Magnetic resonance imaging findings have been described in the past, and are characteristic. There are very few reports of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) findings of this unusual dyskinetic syndrome. This report describes the PET/CT features of this rare disease. Early detection and prompt correction of hyperglycemia may lead to complete or significant amelioration of symptoms.

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