Ganan-Calvo A.M.,University of Seville |
Montanero J.M.,University of Extremadura |
Martin-Banderas L.,University of Seville |
Advanced Drug Delivery Reviews | Year: 2013
In this review, we aim at establishing a relationship between the fundamentals of the microfluidics technologies used in the Pharmacy field, and the achievements accomplished by those technologies. We describe the main methods for manufacturing micrometer drops, bubbles, and capsules, as well as the corresponding underlying physical mechanisms. In this regard, the review is intended to show non-specialist readers the dynamical processes which determine the success of microfluidics techniques. Flow focusing (FF) is a droplet-based method widely used to produce different types of fluid entities on a continuous basis by applying an extensional co-flow. We take this technique as an example to illustrate how microfluidics technologies for drug delivery are progressing from a deep understanding of the physics of fluids involved. Specifically, we describe the limitations of FF, and review novel methods which enhance its stability and robustness. In the last part of this paper, we review some of the accomplishments of microfluidics when it comes to drug manufacturing and delivery. Special attention is paid to the production of the microencapsulated form because this fluidic structure gathers the main functionalities sought for in Pharmacy. We also show how FF has been adapted to satisfy an ample variety of pharmaceutical requirements to date. © 2013 Elsevier B.V.
Ingeniatrics and University of Seville | Date: 2016-08-24
An apparatus is described. The apparatus comprises a liquid dispenser comprising a liquid outlet, the liquid dispenser being configured to generate a droplet stream. The apparatus also comprises a first fluid flow device configured to generate a confinement fluid flow for confining a trajectory of the droplet stream therein, the first fluid flow device comprising an outlet arranged to allow the droplet stream to exit therefrom, wherein the fluid outlet is arranged within the confinement fluid flow device. Furthermore, the apparatus comprises a second fluid flow device configured to generate a reaction fluid flow for reacting with droplets in the droplet stream, wherein the outlet of the first fluid flow device is arranged within the second fluid flow device. A method is also described.
Agency: European Commission | Branch: FP7 | Program: CP-TP | Phase: KBBE.2012.1.2-10 | Award Amount: 8.06M | Year: 2012
European aquaculture production provides direct employment to 65.000 people with a turnover of 3 billion . However, the lack of authorised veterinary medicinal products and the consequent disease outbreaks in farmed fish species costs the sector 20% of the production value. The most appropriate method for disease control, both on economical and ethical grounds, is disease prevention by vaccination. TargetFish will advance the development of existing (but not sufficient) and new prototype vaccines against socio-economically important viral or bacterial pathogens of Atlantic salmon, rainbow trout, common carp, sea bass, sea bream and turbot. The project will develop targeted vaccination strategies for currently sub-optimal and for novel vaccines. Improved vaccines will be brought closer to industrial application by addressing practical issues such as efficacy, safety and delivery route. TargetFish will also establish a knowledge- and technology-base for rational development of next generation fish vaccines. To achieve these challenging tasks, we brought together 29 partners from 11 EU member states, 2 associated countries and 1 International Cooperation Partner Country (ICPC). In this large multidisciplinary consortium an approximate equal number of RTD and SME partners will cooperate closely while keeping an intensive communication with the large vaccine and nutrition industries via an Industry Forum. Specifically, TargetFish will 1) generate knowledge by studying antigens and adjuvants for mucosal routes of administration while analyzing the underpinning protective immune mechanisms; 2) validate this knowledge with response assays for monitoring vaccine efficacy and study safety aspects, including those associated with DNA vaccines; 3) approach implementation of prototype vaccines by optimizing vaccination strategies thus 4) shortening the route to exploitation. Thereby, this project will greatly enhance targeted disease prophylaxis in European fish farming.
Agency: European Commission | Branch: FP7 | Program: CP-IP | Phase: NMP.2013.1.2-2 | Award Amount: 7.53M | Year: 2014
The main objective of PneumoNP is the development of a theragnostic system for the treatment of lung Gram-negative bacterial infections. As a proof of concept PneumoNP will focus the attention on Klebsiella pneumoniae caused infections. A diagnostic kit will be developed to enable a rapid and precise identification of the bacteria strain causing the infection and avoid the use of wide spectrum antibiotics. For the treatment a nanotherapeutic based inhalable antibiotic will be developed. The therapeutic nanosystem will be based on a nanocarrier combined with an antimicrobial peptide. 3 different types of NCs will be tested with 2 AMPs to be able to obtain a novel effective inhalable antimicrobial NS. Nanotherapeutics offers many advantages in pulmonary drug-delivery, due to the huge surface area available in the lungs and their potential to achieve uniform distribution of drug dose among the alveoli. To improve this delivery to the lungs an aerosol system will also be developed. Due to the characteristics related to pulmonary delivery of NCs, topical and systemic bioavailabilities are envisaged. A diagnostic kit will be generated to monitor the efficacy and efficiency of the therapy. Once this treatment is proved to be effective, it could then be applied to any Gram-negative lung bacterial infection. The number of antibiotic resistant bacteria strains is increasing rapidly, new types of therapy are urgently required to avoid the use of standard antibiotics. Gram-negative bacteria that cause pneumonia are one of the main sources of nosocomial infections, mainly in people with a weakened immune system. Apart from pneumonia they can cause bacteremia and other infections. Early detection of the infection source combined with the development of appropriate and effective NSs to treat multi-drug resistant (MDR) bacteria caused infections will definitely radically improve the healing process of patients and avoid complications for people in hospital.
Agency: European Commission | Branch: H2020 | Program: SME-1 | Phase: NMP-25-2014-1 | Award Amount: 71.43K | Year: 2015
FlowcusinUP global innovation project aims at designing an innovative Microencapsulation industrial-strength system sufficiently scalable, adaptable and versatile to fulfil new market opportunities. Ingeniatrics is a highly innovative SME with extensive background in micro-and-nanoscale market and technologies, and with an Intellectual Knowledge protected by over 80 national and international patents (and applications). Despite his proven track record, Ingeniatrics current laboratory-based manufacturing facility couldnt afford the increasing demands of the fast-growing microcapsules market. FlowcusinUP industrialization will improve the efficiency in the process of manufacture, driving Ingeniatrics to produce monodisperse particles with a core-shell full protection and sizes below 100-150 microns. At this moment, there is no system capable of producing microcapsules with ultimate features that allow the patented technologies from Ingeniatrics and with efficient quantity/cost ratio to address industry-wide production. The present FlowcusinUP Phase 1 will undertake technical, economical, operational and marketing-related analysis to validate the profitability of the solution and successful access to global market. At the end of phase 2 FlowcusinUP foresees a reduction of production costs of approximately 50 times, and reduction of production time around 150 times compared to current systems. The future commercialization of the FlowcusinUP outcomes will strengthen EU microparticles ecosystem and related applications (nutraceuticals, agrochemical, pharmaceutical, food, textiles, paper industry...) and will booster Ingeniatrics to a leading position within the microencapsulation market.
Ingeniatrics | Date: 2012-10-09
Scientific analysis apparatus, equipment and instruments for handling fluids at a micro and nanometric scale and devices for controlling the production of microjets, simple and complex microdrops, simple and complex microparticles, microemulsions, microfibers and microbubbles. Import-export agency services; advertising; national and international business management and administration; retail store services and on-line retail store services sale in stores and via global computer networks in connection with apparatus for steam generating, refrigerating, drying, ventilating, water supply and sanitary installations, optical and mass spectrometry apparatus used for chemical and physical analysis and nebulizers. Scientific and technological services, namely, research and design in the field of genetic testing and product development of genetic tests; analysis services, specifically biological, genetic mapping for scientific purposes, bio-physiological, chemical and bacteriological analysis services; industrial and scientific research and engineering services applied to the field of medicine, biotechnology, pharmacology, science in connection with health, plants, cosmetics, veterinary and human consumption and industrial research applied to textiles; genetic testing for scientific research purposes.
Ingeniatrics | Date: 2012-03-06
Scientific apparatus and instruments, namely, nebulizers for fluid manipulation in the nano and micrometric range, nebulizers for controlling the production of micro-jets, single and complex microparticles, microfibres, and microbubbles, and nebulizers for mass and optical spectrometry apparatus for chemical elementary analysis. Advertising; business management; business administration; retail store and on-line retail store services featuring nebulizers for steam generating, cooking, refrigerating, drying, ventilating, water supply and sanitary purposes, mass and optical spectrometry equipment used for chemical elementary analysis.
Ingeniatrics | Date: 2012-07-17
Scientific apparatus and instruments, particularly for handling fluids on a micrometric and nanometric scale and devices enabling control in the generation of microjets, simple and complex microparticles, microfibers and microbubbles. Scientific and technological services, namely, research and design in the field of genetic testing; analysis services, engineering services and scientific and industrial research services applied to the field of medicine, pharmacology and health sciences; biological, chemical and bacteriological research and analysis; genetic testing for scientific research purposes.
Ingeniatrics | Date: 2012-11-13
Machine parts, namely, nozzles which are parts of power-operated sprayers; parts for pneumatic blow guns, namely, nozzles. Plastic spray nozzles.