Burlington, MA, United States
Burlington, MA, United States

Time filter

Source Type

Patent
InfraReDx | Date: 2016-03-04

Methods, devices and systems, including computer-implemented methods for building a lipid core plaque (LCP) cap collagen structural integrity classifier are described. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of the presence of an LCP is determined. Collagen structural integrity indicator data associated with the blood vessel wall are determined. The LCP cap collagen structural integrity classifier is generated based on the reflectance spectrum and the collagen structural integrity indicator data.


A catheter tip apparatus arranged in a catheter for the delivery and collection of an energy signal to permit energy beam analysis of body tissue by the collected signal. The apparatus comprises an elongated housing (150) supporting a first reflective surface (158) for emitting radiation in a first beam toward a target body tissue and a second reflective surface (156) for receiving radiation reflected back from the target body tissue, said first reflective surface and said second reflective surface being longitudinally spaced apart from one another and aligned with first and second channels (166,162), respectively, formed through said housing; a first flexible, elongated energy bearing delivery fiber (168) having a distal portion extending through said first channel (166); a second flexible, elongated energy bearing collection fiber (164) having a distal portion extending through said second housing channel (162); said first and second channels alignably supporting said first and second energy bearing fibers (168,164) such that distalmost ends thereof are adjacent said first and second reflective surfaces (158, 156), respectively; and said housing rotatably supported within a flexible catheter sheath for insertion of said catheter into a mammalian body for tissue analysis thereof.


Patent
InfraReDx | Date: 2010-04-14

A tip assembly for a catheter includes a housing having a recess that receives an optical bench. The optical bench accommodates adjacent fibers, one of which is in optical communication with a first beam re-director. The first beam re-director is oriented to cause a beam incident thereon to travel in a direction away from the optical bench. An engaging structure coupled to the optical bench provides torque coupling between the housing and an end of a torque cable extending axially along the catheter.


Patent
InfraReDx | Date: 2011-08-29

Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed.


Disclosed is a high resolution intravascular ultrasound imaging system including a catheter with a rotatable imaging assembly and an image processor. The image processor in turn features a pulser configured to energize the ultrasound transducer of the rotatable imaging assembly with a multi-frequency ultrasound waveform signal. The image processor further contains a receiver configured to decompose received ultrasound energy as reflected by the target vessel into a plurality of individual subband signals, individually process these signals and reconstitute these signals into a high resolution image of the blood vessel. The IVUS system of the invention may be useful in characterizing cap thickness of vulnerable plaques or other detailed studies of blood vessels.


Methods, apparatus, and systems for intravascular analysis combine at least three analytical modalities. In one implementation, intravascular ultrasound, optical coherence tomography, and near infrared spectroscopy are combined to enable detection of multiple, different abnormalities in the arterial morphology during a single intravascular procedure.


Patent
InfraReDx | Date: 2011-04-13

A catheter tip assembly comprising first and second fibers supported by a housing. The housing includes a recess extending along a longitudinal axis and having a transverse dimension selected to accommodate first and second fibers arranged side-by-side in parallel relation to one another; and an optical bench in said recess includes a first beam re-director in optical communication with the first fiber and a fiber stop disposed between a distal end of the first fiber and the first beam re-director to facilitate placement of the first fiber in relation to the first beam re-director.


Patent
InfraReDx | Date: 2010-03-16

An apparatus for detecting vulnerable plaque within a lumen defined by an intraluminal wall is described. The apparatus includes a probe having a distal portion and a proximal portion. The apparatus includes an optical waveguide extending along the probe. The optical waveguide is configured to carry optical radiation between the distal and proximal portions, and has a distal end in communication with the intraluminal wall. The apparatus includes an interferometer coupled to the optical waveguide and configured to provide an interference signal for sub-surface imaging of the intraluminal wall, and a processing module configured to provide spectroscopic information from detected intensity of light collected from the intraluminal wall.


Patent
InfraReDx | Date: 2015-02-13

Described are methods, systems, and apparatus, including computer program products for examining a blood vessel wall. The blood vessel wall is illuminated with near-infrared light. Reflected near-infrared light from the blood vessel wall is received. A reflectance spectrum based on the reflected near-infrared light from the blood vessel wall is determined. Whether the reflectance spectrum is indicative of a presence of a lipid core plaque (LCP) by applying an LCP classifier to the reflectance spectrum is determined. A thickness of an LCP cap is determined by applying an LCP cap thickness classifier to the reflectance spectrum if the reflectance spectrum is indicative of the presence of the LCP. Indicia of the thickness of the LCP cap are displayed.


Patent
InfraReDx | Date: 2010-11-02

An apparatus for detecting vulnerable plaque within a lumen defined by an intraluminal wall is described. The apparatus includes a probe having a distal portion and a proximal portion. The apparatus includes an optical waveguide extending along the probe. The optical waveguide is configured to carry optical radiation between the distal and proximal portions, and has a distal end in communication with the intraluminal wall. The apparatus includes an interferometer coupled to the optical waveguide and configured to provide an interference signal for sub-surface imaging of the intraluminal wall, and a processing module configured to provide spectroscopic information from detected intensity of light collected from the intraluminal wall.

Loading InfraReDx collaborators
Loading InfraReDx collaborators