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London, United Kingdom

Yu Y.,CAS Shanghai Institutes for Biological Sciences | Yu Y.,University of Chinese Academy of Sciences | Ping J.,Shanghai JiaoTong University | Chen H.,Chinese National Human Genome Center at Shanghai | And 7 more authors.
Genomics | Year: 2010

The human liver plays a vital role in meeting the body's metabolic needs and maintaining homeostasis. To address the molecular mechanisms of liver function, we integrated multiple gene expression datasets from microarray, MPSS, SAGE and EST platforms to generate a transcriptome atlas of the normal human liver. Our results show that 17396 genes are expressed in the human liver. 238 genes were identified as liver enrichment genes, involved in the functions of immune response and metabolic processes, from the MPSS and EST datasets. A comparative analysis of liver transcriptomes was performed in humans, mice and rats with microarray datasets shows that the expression profile of homologous genes remains significantly different between mouse/rat and human, suggesting a functional variance and regulation bias of genes expressed in the livers. The integrated liver transcriptome data should provide a valuable resource for the in-depth understanding of human liver biology and liver disease. © 2010.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH-2007-2.4.2-6 | Award Amount: 3.43M | Year: 2009

The main purpose of the EVINCI-study is to test the impact of combined anatomo-functional non invasive cardiac imaging for detection and characterization of Ischemic Heart Disease (IHD). The EVINCI-study is a prospective clinical European multicenter trial performed in a cohort of 700 patients with suspected IHD. Patients with intermediate pre-test probability will undergo clinical and biohumoral characterization, including novel circulating markers of cardiovascular risk. They will be admitted to a non-invasive cardiac evaluation, consisting of anatomic imaging, by multislice computerized tomography, combined with functional tests among radionuclide, magnetic resonance and ultrasound imaging. Heart catheterization will be performed to validate non-invasive diagnosis and follow-up to assess outcome. The diagnostic accuracy of combined non-invasive anatomo-functional imaging will be tested against reference methods for diagnosing epicardial coronary lesions (coronary angiography), vessel wall atherosclerosis (intracoronary ultrasound) and impaired coronary flow reserve (intracoronary doppler/pressure wire). The individual profiles from anatomo-functional cardiac imaging and clinical-biohumoral data will be combined and tested against outcome. A cost-benefit analysis (including an estimate of procedural/radiological risks) of the new diagnostic work-up will also be performed. A relevant part of the EVINCI-study will be dedicated to the development, in cooperation with the industry, of an advanced informatics platform able to synthetically present to the end-user (patients, physicians, etc.) the integrated cardiological diagnostic profile of the individual patient as resulting from clinical-biohumoral and multi-imaging assessment. Overall results will be disseminated in cooperation with the European Society of Cardiology (ESC) and will guide the work of a dedicated ESC Commission which will release specific European Recommendations.


Trademark
ID BUSINESS SOLUTIONS Ltd and InforSense | Date: 2008-09-02

Computer software, namely, computer software for the analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data, namely, textual or numeric or numeric/textual information, or information presented in textual, numeric or graphic form, in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; knowledge management software in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; computer graphics software; computer software downloaded from the Internet for the analysis, database management, digitizing, transformation, manipulation, integration, mining, retrieval, warehousing, storing, visualization, and formatting of data, namely, textual or numeric or numeric/textual information, or information presented in textual, numeric or graphic form; computer software for analyzing and processing images, graphics, and text in connection with market information in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; computer software for business purposes, namely, the analysis, database management, digitizing, transformation, integration, manipulation, mining, retrieval, warehousing, storing, visualization and formatting of data related to marketing, human resources, research, and sales, in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; computer software for the visualization of market information in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; computer software for the visualization of life science data; computer software for the visualization and analysis of scientific exploration data; data processing software, namely, programs for analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; data processing workflow software, namely, programs for analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; software for Internet-based services, namely, programs for analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; data visualization software, namely, programs for analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; computer software for the analysis and processing of gene expression data, gene sequence data relating to or deriving from the life sciences and research in relation to life sciences and drug discovery; computerized downloadable and recorded databases, namely, databases featuring biological, chemical, life science, and scientific exploration information; computer hardware and firmware for analysis, database management, digitizing, transformation, integration, mining, retrieval, warehousing, storing, manipulation, visualization, and formatting of data in the fields of manufacturing, communications, pharmaceuticals, healthcare, government, finance, and business; blank recording discs. Computerized databases, namely, databases featuring marketing and business information in connection with business services. Scientific research; scientific and technological design for others in the fields of biology, medicine, and genetics; technological research in the fields of medicine, biology, and genetics; industrial analysis and research in the fields of medicine, biology, and genetics; design and development of computer hardware and software; development of computer hardware and software for use in relation to commercial or scientific research; computerized analysis of data, namely, data related to medical, clinical, biological, and genetic information; computerized mining of data; development of computer programs for the visualization of data; software engineering; software development; software programming; professional consultancy relating to computer software; scientific data analysis, namely, analysis of medical, clinical, biological, and genetic information; Computerized non-downloadable databases, namely, databases featuring biological, chemical, life science, and scientific exploration information; consultancy and information services relating to all the above services.


Trademark
ID BUSINESS SOLUTIONS Ltd and InforSense | Date: 2006-01-17

Computer software, namely, computer software for the analysis, management, processing, manipulation, transformation, integration, mining, retrieval, warehousing, storing and visualization of data, namely, textual or numeric or numeric/textual information, or information presented in textual, numeric or graphic form; knowledge management software; computer graphics software; computer software for analyzing or processing market information; computer software for business purposes; computer software for the visualization of market information; computer software for the visualization of life science data; computer software for the visualization and analysis of scientific exploration data; data processing software; data processing workflow software; data communication software; computer software for the analysis and processing of data relating to or deriving from the life sciences and/or research in relation to life sciences; computer software for use in scientific data analysis. Providing online databases in the field of market and business. Scientific research; design and development of computer hardware and software; development of computer hardware and software for use in relation to commercial or scientific research; computer systems analysis; computerized mining of data; computerized intellectual property consultation; development of computer programs for the visualization of data; software engineering; software development, namely, development of data processing workflows; computer programming for others; computer services, namely, professional consultancy relating to computer software; maintenance of computerized databases for others in the field of biological, chemical, life science, market, business or scientific exploration information.

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