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Koch E.-C.,Information and Analysis Center | Klapotke T.M.,Ludwig Maximilians University of Munich
Propellants, Explosives, Pyrotechnics | Year: 2012

The detonation velocity, detonation pressure, and cylinder expansion energy of a series of boron compounds including nitroalkylborates, and mixed amino-nitrosusbtituted borazines, borazenes, iminoboranes, and azaboridines were calculated with Cheetah 2.0. The detonation velocity of the boron compounds is always superior to the all-carbon analogues at the corresponding densities. Nitro-substituted boron compounds bearing amino groups instead of hydrogen display even higher performance. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Sharp M.W.,Information and Analysis Center
Propellants, Explosives, Pyrotechnics | Year: 2016

The NATO Munitions Safety Information Analysis Center (MSIAC) is a multinational collaboration that collects, stores, and analyses technical information related to Munitions Safety (MS) and Insensitive Munitions (IM). MSIAC supports its member nations through a variety of products and services. In addition to a core responsibility of addressing technical questions related to Munitions Safety posed by members, MSIAC has a diverse programme of work aimed at developing and sharing the related underpinning scientific knowledge. This is applied to support munition safety policy development and implementation. This article provides an overview of some of the current and future areas of work which MSIAC is involved in, with a focus on IM and energetic materials. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Metastasis is a critical factor contributing to poor prognosis in cancer, but the underlying mechanisms of metastasis are still poorly understood. We established a highly metastatic cell subline (HOC313-LM) derived from an oral squamous cell carcinoma cell line (HOC313) for uncovering the mechanisms of metastasis, and identified deoxyhypusine synthase (DHPS) as a metastasis-associated gene within the specific amplification at 19p13.2–p13.13 in HOC313-LM. DHPS-mediated hypusine-modification of eukaryotic translation factor 5A facilitated the translation of RhoA, resulting in the activation of the RhoA signaling pathway and leading to not only increased cell motility, invasion and metastasis of cancer cells in vitro, but also increased tumor growth in vivo. Moreover, the use of N1-Guanyl-1,7-diaminoheptane, a DHPS inhibitor, resulted in a significant decrease in tumor formation in vivo. In patients with esophageal squamous cell carcinoma (ESCC), overexpression of DHPS in ESCC tumors was significantly associated with worse recurrence-free survival, and correlated with distant metastasis. The elucidation of these molecular mechanisms within the hypusine cascade suggests opportunities for novel therapeutic targets in SCC.Oncogene advance online publication, 4 April 2016; doi:10.1038/onc.2016.71. © 2016 Macmillan Publishers Limited

Koch E.-C.,Information and Analysis Center | Weiser V.,Fraunhofer Institute for Chemical Technology | Roth E.,Fraunhofer Institute for Chemical Technology
Angewandte Chemie - International Edition | Year: 2012

Deceiving with TNT: Melt-cast pyrotechnic mixtures based on 2,4,6-trinitrotoluene (TNT)/KClO 4 (see picture for flame) spectrally matched infrared decoy flares and show superior performance and greatly reduced sensitivity in comparison to common pyrotechnic or double-base material currently in use for IR countermeasure flares. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Gureyev V.N.,Information and Analysis Center | Mazov N.A.,Russian Academy of Sciences
Information Technology and Libraries | Year: 2013

Bibliometric analyses were used to identify journals that are representative of the authors' research institutes. Methods to semiautomatically collect data for an institute's publications and which journals they cite are described. Citation analyses of lists of articles and their citations can help librarians to quickly identify the preferred journals in terms of the number of publications, and the most frequently cited journals. Librarians can use these data to generate a list of journals that an institute should subscribe to.

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