Cambridge, MA, United States
Cambridge, MA, United States

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Patent
Infinity Pharmaceuticals Inc. | Date: 2016-06-23

Provided herein is a process for the transfer-hydrogenation of ketone analogs of members of the jervine type of Veratrum alkaloids, such as cyclopamine. Also provided herein are novel ruthenium transfer-hydrogenation catalysts.


Solid forms of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphic forms, cocrystals, and amorphous forms thereof, and pharmaceutical compositions thereof.


Patent
Infinity Pharmaceuticals Inc. | Date: 2017-04-26

Provided herein is a method for preparing the compound


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-04-22

Provided herein are tetrazolone FASN inhibitors of the formula (I): or a pharmaceutically acceptable form thereof, wherein the variables R^(A), R^(B )and R^(C )are defined herein. Also provided herein are pharmaceutical compositions of the compounds provided herein as well as methods of their use for the treatment of various disorders such as hyperproliferative disorders, inflammatory disorders, obesity-related disorders and microbial infections.


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-10-25

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.


Patent
Infinity Pharmaceuticals Inc. | Date: 2017-01-25

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-02-04

Polymorphs of chemical compounds that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein. Also provided herein are processes for preparing compounds, polymorphs thereof, and pharmaceutical compositions thereof.


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-02-25

Provided are processes for the synthesis of amino analogues from ketone starting materials.


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-10-10

The invention provides derivatives of cyclopamine having the following formula:


Patent
Infinity Pharmaceuticals Inc. | Date: 2016-02-22

Provided are deglycosylation methods designed to optimize the yield of a Veratrum alkaloid from Veratrum plant material and/or from an extract of Veratrum plant material.

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