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Zhang Z.-Y.,Kaifeng Infectious Diseases Hospital
World Chinese Journal of Digestology | Year: 2013

Aim: To investigate the efficacy of lamivudine combined with adefovir dipivoxil in the management of chronic hepatitis B with acute or subacute liver failure. Methods: Thirty-four chronic hepatitis B patients with acute or sub-acute liver failure were treated with a combination of lamivudine and adefovir, apart from traditional internal therapy. Fifty-four patients who were treated with traditional internal therapy only during the same period were used as controls. The results were compared between the two groups. Results: Significantly lower levels of serum total bilirubin, alanine aminotransferase and HBV DNA were detected in the combination group compared with the control group (242.7 μmol/L ± 72.5 μmol/L vs 347.4 μmol/L ± 97.6 μmol/L, 140.2 U/L ± 59.0 U/L vs 244.1 U/L ± 65.1 U/L, 4.22 copies/L ± 1.02 copies/L vs 6.37 copies/L ± 1.35 copies/L). Prothrombin activity was significantly higher at weeks 4, 8 and 12 in the treatment group than in the control group (55.2% ± 11.2% vs 30.9% ± 11.7%, 78.3% ± 27.8% vs 53.6% ± 17.1%, 96.4% ± 20.1% vs 72.7% ± 28.3%). The mortality at weeks 24 and 48 in the treatment group was significantly lower than that in the control group (14.7% vs 33.3%, 14.7% vs 35.2%). Conclusion: Lamivudine combined with adefovir is more effective than the traditional internal therapy in the management of acute or sub-acute liver failure associated with chronic hepatitis B. © 2013 Baishideng. All rights reserved. Source

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