Quanzhou Infectious Disease Hospital

Quanzhou, China

Quanzhou Infectious Disease Hospital

Quanzhou, China
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Zhuang Q.-Q.,Fujian Medical University | Lin Z.-H.,Fujian Medical University | Jiang Y.-C.,Fujian Medical University | Deng H.-H.,Fujian Medical University | And 5 more authors.
International Journal of Nanomedicine | Year: 2017

Dendrite-like cobalt selenide nanostructures were synthesized from cobalt and selenium powder precursors by a solvothermal method in anhydrous ethylenediamine. The as-prepared nanocrystalline cobalt selenide was found to possess peroxidase-like activity that could catalyze the reaction of peroxidase substrates in the presence of H2O2. A spectrophotometric method for uric acid (UA) determination was developed based on the nanocrystalline cobalt selenide-catalyzed coupling reaction between N-ethyl-N-(3-sulfopropyl)-3-methylaniline sodium salt and 4-aminoantipyrine (4-AAP) in the presence of H2O2. Under optimum conditions, the absorbance was proportional to the concentration of UA over the range of 2.0–40 μM with a detection limit of 0.5 μM. The applicability of the proposed method has been validated by determination of UA in human serum samples with satisfactory results. © 2017 Zhuang et al.

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