Industrial Technology Research Institute

United States

Industrial Technology Research Institute

United States
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The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.


Patent
Industrial Technology Research Institute | Date: 2013-06-19

The present disclosure provides a brush polymer, including: a linear polymer main chain; and brush structural side chains, including: a hydrophobic molecular branch, and a hydrophilic molecular branch and/or an anti-biofilm /or an anti-microbial molecular branch, wherein the linear polymer main chain is conjugated to the side chains by covalent bonds formed between a hydroxyl group and a reactive functional group, wherein the reactive functional group includes: isocyanate, carboxyl, or epoxy. The present disclosure also provides a medical application of the brush polymer.


Patent
Industrial Technology Research Institute | Date: 2015-12-11

Provided is an adsorption material including a plurality of porous silicate particles having a glass-phase structure and including silicon oxide, aluminum oxide, barium oxide, strontium oxide and boron oxide. An average pore size of the plurality of porous silicate particles is in a range of from 3 nm to 50 nm, and a zeta potential of the plurality of porous silicate particles is negative at a pH value of from 1 to 5. A method of fabricating the adsorption material is further provided.


An inorganic material for removing a harmful substance from wastewater is provided. The inorganic material includes a plurality of porous silicate particles having a glass phase structure, wherein the plurality of porous silicate particles include silicon dioxide, aluminum oxide, barium oxide, cesium oxide, and boron oxide, and have a zeta potential of a negative value at pH of from 1 to 5, and wherein the average pore diameter of the porous silicate particles is in a range of from 3 to 50 nm. Moreover, a method for preparing an inorganic material for removing a harmful substance from wastewater and a method for wastewater treatment are further provided.


Patent
Industrial Technology Research Institute | Date: 2014-06-18

The present disclosure provides a flexible non-combustible fire-resistant material, including: 5-20 parts by weight of polyurethane having an NCO content of about 1-50 wt%; 1-10 parts by weight of liquid fire retardant; and 50-90 parts by weight of hydroxyl-containing inorganic fire retardant, wherein the polyurethane reacts with the hydroxyl-containing inorganic fire retardant to form a chemical bond, and wherein the hydroxyl-containing inorganic fire retardant includes at least two different particle sizes.


Patent
Industrial Technology Research Institute | Date: 2013-08-07

Use of urine and serum biomarkers in diagnosing diabetic nephropathy, staging diabetic nephropathy, monitoring diabetic nephropathy progress, and assessing efficacy of diabetic nephropathy treatments. These biomarkers include urine precursor alpha-2-HS-glycoprotein, urine alpha-1 antitrypsin, urine alpha-1 acid glycoprotein, urine osteopontin, serum osteopontin, their fragments, and combinations thereof.


Patent
Industrial Technology Research Institute | Date: 2012-04-27

An extract of Cynanchum sp. in use of arthritis treatment is provided. The extract of Cynanchum sp. and an active ingredient contained therein, antofine, are applicable to a method, pharmaceutical composition and dietary supplement for treatment of arthritis. A mass production of antofine from plant extracts is also provided.


Patent
Industrial Technology Research Institute | Date: 2014-03-19

A method of identifying a target biological material by using captures and probes. Each capture is specific for a kind of target. Each probe is designed to distinguish the type of the target. The captures and probes are each labeled with one or more detectable labels.


Patent
Industrial Technology Research Institute | Date: 2015-12-30

A battery electrode paste composition containing a silane coupling agent-modified active substance is provided. The battery electrode paste composition includes a silane coupling agent-modified active substance, a conductive additive, an adhesive, and a maleimide additive. The composition containing the silane coupling agent-modified active substance may provide better battery safety and longer cycle life.


Patent
Industrial Technology Research Institute | Date: 2013-03-06

Provided are methods for recycling liquid crystal comprising: receiving at least one liquid crystal mixture; and forming a reformulated liquid crystal mixture using at least one portion of the at least one liquid crystal mixture. Also provided are reformulated liquid crystal mixtures comprising at least one recycled liquid crystal mixture and liquid crystals displays devices having one or more reformulated liquid crystal mixtures.

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