PubMed | Libragen, Induchem AG, Induchem and Cosmetic Inventions
Type: Clinical Study | Journal: International journal of cosmetic science | Year: 2015
The aims of this study were to confirm the properties of selective agonist peptide (Rubixyl) contained in the spinach towards opioid receptor delta. In fact, agonist properties of both spinach peptides (Rubiscolin-5 and Rubixyl) towards opioid receptor delta were demonstrated by Zang etal., but their effects on the other opioid receptors were not studied . We also studied the expression of opioid receptor delta in epidermis under normal and stress condition (inflammatory) and its role in epidermis homeostasis under stress condition invitro and invivo.Agonist properties studies were performed using functional agonist cellular model containing human opioid receptors. Opioid receptor delta expression and epidermis homeostasis were studied on human reconstructed epidermis under normal and stress conditions (inflammatory stress) using gene expression (RT-qPCR) and protein expression analysis (immunohistological analysis). Skin repair properties of opioid receptor delta agonist were based on the following parameters TEWL (trans epidermal water loss, hydration and wrinkle depth at periocular and perilabial area) on human volunteers having either intrinsic ageing (more than 40years old and non-smoker group) and both intrinsic ageing and extrinsic ageing (more than 40years old and smoker group).We have demonstrated that the Rubixyl peptide is a specific agonist of opioid receptor delta. We have demonstrated that opioid receptor delta expression is modulated under inflammatory condition. The agonist Rubixyl was able to block the depletion of opioid receptor delta seen under inflammatory condition in reconstructed human epidermis. Inflammatory conditions lead to the unbalanced gene and protein expressions of markers involved in epidermis integrity and barrier function properties. The treatment of human reconstructed epidermis with the agonist Rubixyl leads to the normalization of unbalanced gene and protein expressions. In vivo study has confirmed the efficiency of the agonist Rubixyl to repair damaged skin by decreasing TEWL, increasing hydration and decreasing wrinkle depth at the periocular and perilabial area.In this research, we have demonstrated invitro (on inflamed reconstructed human epidermis, RHE) and invivo (on human aged volunteers) that activation by natural agonist peptide of opioid receptor delta reduces the skin inflammation thus leading to improvement in epidermis differentiation and skin barrier properties.
PubMed | Induchem AG, Libragen SA and Cosmetic Invention
Type: | Journal: Clinical, cosmetic and investigational dermatology | Year: 2015
3,4,5-Trihydroxybenzoic acid glucoside (THBG), a molecule produced by an original biocatalysis-based technology, was assessed in this study with respect to its skin photoprotective capacity and its skin color control property on Asian-type skin at a clinical level and on skin explant culture models.The double-blinded clinical study was done in comparison to a vehicle by the determination of objective color parameters thanks to recognized quantitative and qualitative analysis tools, including Chroma-Meter, VISIA-CR, and SIAscope. Determination of L* (brightness), a* and b* (green-red and blue-yellow chromaticity coordinates), individual typology angle, and C* (chroma) and h* (hue angle) parameters using a Chroma-Meter demonstrated that THBG is able to modify skin color while quantification of ultraviolet (UV) spots by VISIA-CR confirmed its photoprotective effect. The mechanism of action of THBG molecule was determined using explant skin culture model coupled to histological analysis (epidermis melanin content staining).We have demonstrated that THBG was able to modulate significantly several critical parameters involved in skin color control such as L* (brightness), a* (redness), individual typology angle (pigmentation), and hue angle (yellowness in this study), whereas no modification occurs on b* and C* parameters. We have demonstrated using histological staining that THBG decrease epidermis melanin content under unirradiated and irradiated condition. We also confirmed that THBG molecule is not a sunscreen agent.This study demonstrated that THBG controls skin tone via the inhibition of melanin synthesis as well as the modulation of skin brightness, yellowness, and redness.
News Article | November 10, 2016
According to a new market report published by Future Market Insights titled “Computer Keyboards Market - Global Industry Analysis and Opportunity Assessment 2015 - 2025,” the global computer keyboards market was valued at US$ 4,780.5 Mn in 2014 and is expected to register a CAGR of 2.3% from 2015 to 2025. Growth of the computer keyboards market is primarily driven by increasing sales of ergonomic keyboards. Ergonomic keyboards are designed to reduce muscular stress and conditions such as carpal tunnel syndrome and repetitive stress injuries (RSIs) that result from persistent keyboard usage. On the basis of type, the computer keyboards market is segmented into basic and ergonomic keyboards. The basic keyboards segment was valued US$ 4,287.4 Mn in 2014 and is anticipated to register a CAGR of 0.8% during the forecast period 2015–2025. This sluggish growth can be attributed to rising adoption of ergonomic keyboards by heavy users as they prevent RSIs and Musculoskeletal disorders (MSDs). Leading players, such as Microsoft Corporation, Logitech International SA, Gold Touch Inc., and Fellowes Inc., who manufacture basic keyboards are shifting towards ergonomic keyboards production in order to capitalize on the high demand for the same. Additionally, tools and user interface technologies such as speech processing, brain mapping interface, and most importantly touchscreen keyboards are expected to impact the adoption of computer keyboards significantly in the near future. Ergonomic keyboards accounted for 10.3% share of the total computer keyboards market in 2014. Adoption of ergonomic keyboards is expected to increase at a strong rate due to growing awareness about their benefits such as comfortable positioning of the hand, wrist, and forearm, and easy approach to keys (due to the curved key layout which reduces stress while typing). The ergonomic keyboards market is further segmented on the basis of type (vertical, compact, adjustable, split, and others), switching mechanism (membrane based and mechanical), size (standard, laptop, thumb-size, and numeric keyboards), and applications (corporate, personal, and gaming). This report covers trends driving each segment and offers analysis and insights regarding the potential of the computer keyboards market in key regions including North America, Latin America, Eastern Europe, Western Europe, Asia Pacific (excluding Japan), Japan, and the Middle East & Africa. North America accounted for the largest market share in 2014, owing to growing complaints of RSIs and carpal tunnel syndrome at workplaces. In order to increase operational productivity, enterprises in this region are adopting ergonomic workstation solutions including keyboards, mice, and office furniture. In terms of value, Asia Pacific (including Japan) commanded 21% share of the total ergonomic keyboards market in 2014. The region is expected to witness the highest growth throughout the forecast period, owing to increasing adoption of ergonomic keyboards in countries such as India, China, Japan, South Korea, Singapore, and the Philippines. Market growth across these countries is primarily driven by growing numbers of multinational companies, such as Tata Group, Intel Corporation, Global Sources, Induchem AG, and HubSpot, Inc., establishing offices in the region. In order to make the most of this opportunity, computer keyboard manufacturers (especially ergonomic keyboards manufacturers) are expected to expand distribution channels in this region during the forecast period. Key players of the global computer keyboards market include Microsoft Corporation, Logitech International SA, Kinesis Corporation, Gold Touch Enterprises Inc., Adesso Inc., Fellowes Inc., Posturite Ltd., Datadesk Technologies, Fentek Industries, Inc., and Shenzhen V4 Electronics Co., Ltd.
PubMed | Induchem AG, Libragen SA and French National Center for Scientific Research
Type: | Journal: Clinical, cosmetic and investigational dermatology | Year: 2015
Rosacea, a common chronic skin disorder, is currently managed by patient education, pharmacological drugs, medical devices (laser and light therapies), and use of proper skin cares. Unfortunately, none of these actual treatments used alone or in combination is curative, and so we proposed a dermocosmetic active ingredient to mitigate some aspects of the rosacea and particularly for erythematotelangiectatic rosacea.Dermocosmetic active ingredient is composed of three glucosylated derivatives of natural plants hydroxybenzoic acid and hydroxycinnamic acids (rosmarinic acid, gallic acid, and caffeic acid). Anti-inflammatory, anti-angiogenesis, and anti-degranulation studies were done on cellular models (keratinocytes, mast cells, and endothelial cells). Efficiency of the active ingredient in comparison to placebo was assessed clinically on human volunteers having erythematotelangiectatic rosacea. The active and placebo were applied topically twice a day for 28 days. Biometrical analyses were done using a siascope tool.We found that the active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and controls angiogenesis mechanism (inhibition of the production of vascular endothelial growth factor and neovessel formation) on cellular models. Study on human volunteers confirmed macroscopically the efficiency of this active ingredient, as we observed no neovessel formation and less visible vessels.Although rosacea is a skin condition disorder that is difficult to heal, the studies have shown that this active ingredient could be a dermocosmetic support, especially for erythematotelangiectatic rosacea armamentarium. The active ingredient was topically applied on the face for 28 days and improved erythematotelangiectatic rosacea symptoms either by decreasing them (vessels are less visible) or by limiting their development (any neovessels). The active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and limits the angiogenesis process (inhibition of vascular endothelial growth factor production and neovessel formation).
Ebrahimi S.N.,University of Basel |
Ebrahimi S.N.,Shahid Beheshti University |
Gafner F.,Induchem AG |
Dell'Acqua G.,Induchem AG |
And 2 more authors.
Helvetica Chimica Acta | Year: 2011
Phytochemical profiling of a MeOH extract from Haberlea rhodopensis by a combination of liquid/liquid extraction, and preparative and semi-preparative HPLC afforded three new flavone C-glycosides, hispidulin-8-C-(2″-O- syringoyl)-β-glucopyranoside (3), hispidulin 8-C-(6-O-acetyl-β- glucopyranoside) (4), and hispidulin 8-C-(6-O-acetyl-2-O-syringoyl-β- glucopyranoside) (5), along with two known phenolic glycosides, myconoside (1) and paucifloside (2). The structures were established by extensive spectroscopic analyses including 1D- and 2D-NMR (COSY, HSQC, and HMBC), and HR-ESI-TOF-MS, and by comparison with published data. Copyright © 2011 Verlag Helvetica Chimica Acta AG, Zürich, Switzerland.
Naumann S.,Institute of Pharmacy |
Naumann S.,Martin Luther University of Halle Wittenberg |
Lange S.,Symrise AG |
Polak G.,Evonik Industries |
And 5 more authors.
Skin Pharmacology and Physiology | Year: 2014
The effect of the lipophilicity of a carrier on human skin penetration of an extremely lipophilic active model substance was evaluated by using Franz type diffusion cells. Oil-in-water model emulsions containing different amounts of the oily phase were prepared, and Myritol® PC (M-PC) was selected as lipophilic marker component of the oily phase. The penetrated amounts of the lipophilic model substance salicyloyl phytosphingosine (SP) were determined by high-performance liquid chromatography with ultraviolet detection, while M-PC was detected using gas chromatography coupled with mass spectrometry. It has been ascertained that the amount of the lipid phase within the emulsion influenced the penetration profile of the active ingredient SP. The emulsion containing the lowest proportion of the lipid phase provides the best conditions for SP penetration. Surprisingly, the penetration behavior of M-PC was influenced by the oily phase in the same way. Regarding the M-PC and the SP penetration profiles from each emulsion, a solvent drag mechanism can be assumed whereby M-PC acts as penetration enhancer. In conclusion, the penetration rate of the active ingredient SP and the marker component M-PC are in reverse proportion to the oil content of the formulations. The lipophilicity of SP and M-PC, their solubility and their thermodynamic activity within the vehicle could have an effect on their penetration behavior. Additionally, M-PC has the property to enhance the penetration rates of extremely lipophilic substances even at low concentrations. © 2013 S. Karger AG, Basel.
Dell'Acqua G.,Induchem AG |
Schweikert K.,Induchem AG
International Journal of Cosmetic Science | Year: 2012
Synopsis Resurrection plant Haberlea rhodopensis develops molecules to survive drought stress. These molecules allow the plant to resurge from a desiccation state. We have extracted a specific fraction from the plant (Haberlea extract) and found it rich, among other molecules, of a caffeoyl phenylethanoid glycoside called myconoside, a molecule extremely abundant in the plant with a potential role in survival. Peroxide-stressed normal human dermal fibroblasts treated with the Haberlea extract, showed increased collagen VI (+822%), collagen XVI (+928%) and elastin (+144%) mRNA synthesis, measured by RT-qPCR. This effect was superior to those obtained with benchmarks retinoic acid and retinol. When used at 3% in human skin biopsies, Haberlea extract protected against UV-induced dermis oxidation by 100% (P < 0.01), as evidenced by immunohistochemistry. Finally, when tested in human volunteers (n = 20) at 3% in a cream against a placebo, Haberlea extract increased skin elasticity (3× placebo, P < 0.0002) and skin radiance (4× placebo, P < 0.05) after only 15 days of treatment, with the effect sustained after 30 and 60 days of treatment. We demonstrated that by using Haberlea extract (particularly rich in glycoside myconoside), it is possible to strongly stimulate antioxidant skin defences and extracellular matrix protein synthesis. This effect, in turn, will further stimulate skin elasticity and skin radiance significantly in human volunteers. The extract can be suggested for anti-ageing treatments, intended for claims such as protection from oxidation, increased skin elasticity and enhanced skin radiance. © 2011 Induchem AG. ICS © 2011 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Dell'Acqua G.,Induchem AG
Journal of cosmetic science | Year: 2012
Vitamin B5 and its derivatives are well known in personal care applications and are often used in wound healing and soothing compositions. However, little is known about the biochemical pathways involved. A better knowledge of these pathways would help to understand some of the mechanisms of action and suggest further applications. We have investigated the transformation of D-panthenyl triacetate (PTA) into D-panthenol (PAN) and its skin diffusion on human volunteers by Raman spectroscopy. Additionally, we have utilized human skin biopsies and quantitative RT-PCR to demonstrate the effect of PTA compared to PAN on 27 metabolic markers when introduced at 2% in a cosmetic emulsion. Then we conducted a double-blind clinical study to measure the effect of PTA compared to PAN on wound healing, measured by transepidermal water loss (TEWL), when incorporated at 3% in a cosmetic emulsion. Results show de-acetylation of PTA into PAN and an increased activity of PTA compared to PNA over time in the skin. Metabolic marker analysis demonstrates stimulation of energetic pathways such as glycolysis and the citric acid cycle, but also of synthesis pathways such as isoprenoids and lipid synthesis, by PTA and PAN. Finally, the clinical study demonstrates a statistically significant effect by PTA on wound healing after 72 hours when compared to a saline treatment. Statistical significance was not achieved by PAN or a placebo treatment. Due to the differences between PTA and PAN action, different applications in personal care products can be suggested. Moreover, PTA seems more effective than PAN for a long-lasting wound healing action.
Schweikert K.,Induchem AG |
Gafner F.,Induchem AG |
Dell'Acqua G.,Giorgio dellAcqua Dellacqua Consulting
International Journal of Cosmetic Science | Year: 2010
Synopsis UV light induces multiple damages including protein oxidation on skin. Oxidized proteins if not degraded by the proteasome would eventually accumulate causing metabolic damage, elastosis and pigment formation such as lipofuscin. During ageing, the activity of the proteasome decreases dramatically together with enzymes that protect from oxidation and as a result oxidized proteins accumulate. We have investigated a combination of Panthenyl triacetate and Ethyl linoleate (bioactive complex) to fight against protein oxidation. This complex when tested at 3% on human skin biopsies showed statistically significant protection from UV (UVA + UVB)-induced protein oxidation both in a 24-h pre-treatment before UV irradiation (72% protection, P < 0.05) and immediately after irradiation (78% protection, P < 0.05). UV light also induced a significant decrease of mRNA for protein repairing enzymes, such as Methionine Sulfoxide Reductase (MSR). The complex, given both pre- and post-irradiation, stimulated the repairing enzyme expression. We can suggest utilization of this new complex to prevent accumulation of oxidized protein as a result of skin photo-ageing and to prevent stratum corneum dehydration, skin elastosis and pigmentation formation (age spots). © 2009 Society of Cosmetic Scientists and the Société Française de Cosmétologie.
Induchem Ag | Date: 2015-08-19
The present invention relates to cellulose particles with measurable exfoliation properties in a cosmetic composition, and uses thereof in the cosmetic field.