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Ratnāgiri, India

Khandare J.,Piramal Life science Ltd. | Patil M.,Indira Institute of Pharmacy | Khade T.,Indira Institute of Pharmacy | Gavitre B.,Indira Institute of Pharmacy | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Polymer-drug conjugates have demonstrated several advantages over the corresponding parent drugs, including fewer side effects, enhanced therapeutic efficacy, ease of drug administration, and improved patient compliance. Polymer-drug conjugates are nano-sized hybrid constructs that covalently combine a bioactive agent with a polymer to ensure not only its efficient delivery to the required intracellular compartment but also its availability within a specific period of time. Polymer-drug conjugates such as HMPA Copolymer-Doxorubicin (PK1), HMPA Copolymer-Doxorubicin-Galactosamine (PK2), HMPA Copolymer-Camptothecin, HMPA Copolymer-Platinate (AP5346), PEG-Camptothecin (Pegamotecan) and PEG-SN38 (EZN-2208) have main role in treatment of a wide variety of human pathologies, from diabetes, heart failure, and brain stroke. Future generation of polymer-drug conjugates will have to meet a number of challenges, including the development of novel polymers with modulated rates of degradation, versatile conjugation chemistry allowing site-specific attachment of targeting moieties. © 2010 RJPBCS.

Pattan S.R.,PRCOP | Kittur B.S.,JKK Nataraja Dental College and Hospital | Sastry B.S.,Andhra University | Jadav S.G.,Indira Institute of Pharmacy | And 3 more authors.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2011

A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds are evaluated for antidiabetic activity on albino rats. Most of these compounds show promising antidiabetic activity.

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