Indira Institute of Pharmacy

Ratnāgiri, India

Indira Institute of Pharmacy

Ratnāgiri, India
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Mane P.P.,Indira Institute of Pharmacy
Indian Journal of Pharmaceutical Sciences | Year: 2014

Nebivolol, a cardioselective β-blocker undergoes extensive metabolism in the liver after its oral administration resulting in low bioavailability. Oral administration of nebivolol also causes gastrointestinal disturbances characterised by stomach ache. To overcome these short comings, mucoadhesive buccal films of nebivolol were prepared using different concentrations of hydroxypropyl methylcellulose and hydroxyl ethylcellulose in the ratios of 2:1, 4:1 and 6:1 and hydroxypropyl methylcellulose and methylcellulose in the ratio of 2:2, 4:3 and 6:4 by solvent casting technique. All the prepared films were found to be smooth, elegant and uniform in thickness and weight. Among the three polymer combinations used, 6:4 (BFN 6 ) showed increased in vitro residence time, which appeared to be mainly due to mucoadhesive nature of hydroxylpropyl methylcellulose and methylcellulose. Evaluation of the films showed uniform dispersion of the drug throughout the formulation (96.21±0.71 to 97.02±0.12%). In vitro drug release studies showed better results at the end of 8 h. The release profile of all the formulations was subjected to kinetic analyses, which suggested that the drug was released by diffusion mechanism following super case-II transport.

Khandare J.,Piramal Life science Ltd. | Patil M.,Indira Institute of Pharmacy | Khade T.,Indira Institute of Pharmacy | Gavitre B.,Indira Institute of Pharmacy | And 3 more authors.
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2011

Polymer-drug conjugates have demonstrated several advantages over the corresponding parent drugs, including fewer side effects, enhanced therapeutic efficacy, ease of drug administration, and improved patient compliance. Polymer-drug conjugates are nano-sized hybrid constructs that covalently combine a bioactive agent with a polymer to ensure not only its efficient delivery to the required intracellular compartment but also its availability within a specific period of time. Polymer-drug conjugates such as HMPA Copolymer-Doxorubicin (PK1), HMPA Copolymer-Doxorubicin-Galactosamine (PK2), HMPA Copolymer-Camptothecin, HMPA Copolymer-Platinate (AP5346), PEG-Camptothecin (Pegamotecan) and PEG-SN38 (EZN-2208) have main role in treatment of a wide variety of human pathologies, from diabetes, heart failure, and brain stroke. Future generation of polymer-drug conjugates will have to meet a number of challenges, including the development of novel polymers with modulated rates of degradation, versatile conjugation chemistry allowing site-specific attachment of targeting moieties. © 2010 RJPBCS.

Chalke T.P.,Indira Institute of Pharmacy | Dorle A.D.,Indira Institute of Pharmacy | Sharma K.R.,Indira Institute of Pharmacy | Nagare S.K.,Indira Institute of Pharmacy | Jirge S.S.,Indira Institute of Pharmacy
International Journal of Pharmaceutical Research | Year: 2017

The present study deals with formulation of bioactive extract of leaves of Anacardium occidentale (cashew) into a dental gel and its evaluation. Dried, powdered bark was extracted with ethanol for 18 hours in a soxhlet apparatus. Catechin is one of the main constituent of the polyphenol of cashew leaves and same was further extracted from ethanol extract. Five dental gels containing catechin rich extract were formulated using various gelling agents. These gels were evaluated for physicochemical parameters, viscosity, spreadibility, extract content, dissolution, mucoadhesion, toxicity, in vitro permeation studies and antimicrobial activity. The selected gel was obtained as a brownish red colored lustrous gel having pH between 7.3-7.5 with a good spreadibility of 4-5secs and mucoadhesive force of 0.1gm. The content of catechin in the gel was 101.25% w/w by HPTLC method. The gel showed significantly good antimicrobial activity to that of ethanol extract and catechin rich extract. In dissolution studies the extract is released completely within 4 hours. In in-vitro permeation studies the entire extract is released within 6 hours. A dental gel was successfully formulated containing catechin rich extract of leaves of Anacardium occidentale. © 2017, Association of Indian Pharmacist. All rights reserved.

Jadhav S.G.,Indira Institute of Pharmacy | Pattan S.R.,Indira Institute of Pharmacy
Indian Drugs | Year: 2012

A new series of substituted benzimidazole derivatives were synthesized and the structures of these compounds were established on the basis of spectral data. The title compounds were evaluated for antimicrobial activity. Some of these compounds have shown excellent antimicrobial activity.

Chalke T.,Indira Institute of Pharmacy | Sharma K.,Indira Institute of Pharmacy | Nagare S.K.,Indira Institute of Pharmacy | Jirge S.S.,Indira Institute of Pharmacy
International Journal of Drug Delivery Technology | Year: 2016

Dried, powdered peel of Punica granatum was extracted with aqueous as solvent using soxhlet. Topical formulation gels were formulated with different combination of polymers and aqueous extract of punica. These formulations were evaluated for their physicochemical parameters, viscosity, spreadability, gallic acid content (by HPLC) and antimicrobial activity. Gel was successfully formulated and evaluated for the pharmaceutical parameters of the formulation and also for the content of gallic acid (3.5%). The gel gave very well anti bacterial and anti fungal activity. The in-house punica gel showed most effective antimicrobial activity against B. subtilis, P. aeruginosa, K. Pneumonia, A. niger. © 2016, International Journal of Drug Delivery Technology. All rights reserved.

Pattan S.R.,PRCOP | Kittur B.S.,JKK Nataraja Dental College and Hospital | Sastry B.S.,Andhra University | Jadav S.G.,Indira Institute of Pharmacy | And 3 more authors.
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry | Year: 2011

A new series of 1,3,4-thiadiazole derivatives are synthesized and the structures of these compounds have been established on the basis of spectral and elemental analysis. All the compounds are evaluated for antidiabetic activity on albino rats. Most of these compounds show promising antidiabetic activity.

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