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Basu S.,Indira Gandhi Medical College and Research Institute
International Journal of Pharma and Bio Sciences | Year: 2013

The prevalence of metabolic diseases in the urban and semi-urban population in India is high. Most people are unaware of the risks associated with obesity, diabetes mellitus, hypertension and dyslipidemia. This study was undertaken to find the association between Body Mass Index (BMI) and the fasting levels of blood glucose, triacylglycerol along with hypertension in the local population who were apparently healthy.One hundred and nine healthy people were segregated into four group based on BMI- Lean, Normal, Overweight and Obese. The mean values of fasting and post- prandial blood sugar and fasting triglyceride and the range of systolic and diastolic blood pressure was found to increase with the increase in BMI in the four groups. Fifteen cases were found to have Metabolic Syndrome.A close association of the risk factors for cardiovascular diseases with increasing BMI was found to exist in the population studied during a routine health check-up. Source


Ramadass S.,Indira Gandhi Medical College and Research Institute | Srinivasan A.R.,Mahatma Gandhi Institute
Diabetes and Metabolic Syndrome: Clinical Research and Reviews | Year: 2015

Context Magnesium deficiency is commonly associated with endocrine and metabolic disorders, especially with Diabetes Mellitus type 2 though the mechanism of hypomagnesemia in Diabetes Mellitus is not completely known. There is a close association between metabolic control of Diabetes Mellitus and impaired magnesium balance. Aims To estimate the serum levels of magnesium in patients of with Diabetes Mellitus type 2 and to find a correlation if any, with the duration and control (by estimating HbA1c) of Diabetes Mellitus type 2. Materials and methods Fifty patients of Diabetes Mellitus type 2 were included in the study. Blood samples were analyzed for fasting and post prandial glucose, HbA1c and magnesium. The patients were grouped into three categories based upon their HbA1c levels into those with good control, need intervention and poor control. The three groups were compared with reference to their mean levels of blood glucose and magnesium. Association of serum magnesium levels with HbA1c, Fasting and postprandial blood glucose and duration of Diabetes Mellitus was also done. Results Serum magnesium levels were found to decline with rise in HbA1c levels and with duration of Diabetes Mellitus type 2. Conclusion Hypomagnesemia is linked to poor control of Diabetes Mellitus type 2 and depletion of serum magnesium occurs exponentially with duration of disease. © 2014 Diabetes India. Published by Elsevier Ltd. All rights reserved. Source


Niranjan V.,Indira Gandhi Medical College and Research Institute | Malini A.,Indira Gandhi Medical College and Research Institute
Indian Journal of Medical Research | Year: 2014

Background & objectives: Recent studies suggest an increasing antimicrobial resistance among Escherichia coli causing urinary tract infection (UTI). We undertook this study to know the resistance pattern of E. coli causing UTI in patients admitted to a tertiary care hospital in north India, and to know the treatment given and response of the patients. Methods: The details of E. coli grown from urine samples and their antibiotic sensitivity pattern were collected from the laboratory registers and the patient details were collected from the case records. The urine samples received were processed using standard methods and antibiotic susceptibility was done by Kirby-Bauer disk diffusion test. Results: of the total 311 E. coli isolates, 119 (38.2%) were isolated from in-patients, which were considered for the study. of these 119 E. coli isolates, 91 (76.51%) were multi drug resistant (MDR). The isolates showed high levels of resistance to ampicillin (88.4%), amoxicillin-clavulanic acid (74.4%), norfloxacin (74.2%), cefuroxime (72.2%), ceftriaxone (71.4%) and co-trimoxazole (64.2%). The isolates were sensitive to amikacin (82.6%), piperacillin-tazobactum (78.2%), nitrofurantoin (82.1%) and imipenem (98.9%). Ceftriaxone was most commonly used for empirical therapy for UTI among inpatients in our hospital. of the 93 cases of UTI due to MDR E. coli, 73 improved on treatment and 12 worsened, which were referred to higher centres. Interpretation & conclusions: our study showed that 76.5 per cent of E. coli isolates from urine samples of inpatients were MDR. Diabetes, chronic renal disease and catherization were some of the risk factors associated. The high rate of resistance could be because only inpatients were included and the increased usage of cephalosporins in our hospital for empirical therapy. Source


Nath A.K.,Indira Gandhi Medical College and Research Institute
Dermatology online journal | Year: 2012

Cylindroma is a benign skin appendageal tumor arising from pluripotent stem cells in the folliculo-sebaceous-apocrine unit. Multiple cylindromas are usually seen as a component of Brooke-Spiegler syndrome (BSS) or as the only skin lesions of familial cylindromatosis (FC). The usual site of occurrence of such tumors is the scalp. We report a case of multiple cylindromas involving the face without any other feature of BSS and no family history supporting the possibility of FC. Multiple cylindromas of 7 years duration, confirmed by histopathological examination of multiple biopsies, were seen on the face of a 70-year-old woman. There was no history of similar lesions in any of her family members. Examination of the scalp revealed no lesions. Surgical excision of the larger lesions was performed to improve the facial appearance of the patient. This case is being reported for the unusual occurrence of multiple cylindromas only on the face without any features of BSS or FC. Source


Sivagnanam G.,Indira Gandhi Medical College and Research Institute
Journal of Pharmacology and Pharmacotherapeutics | Year: 2010

Mesotherapy involves the use of multiple intradermal or subcutaneous injections of a mixture of compounds in minute doses, by means of very fine needles, directly over/near the affected sites. Originally invented in France to manage painful medical conditions, it is presently the buzz word in the field of cosmetic dermatology, chiefly to get rid of disfiguring fat. Depending upon the condition treated, the drugs injected, the techniques followed and the number of sessions involved vary. The wider reception of mesotherapy by its stakeholders are probably due to factors like inexpensive equipments, relatively minimal training for providers, much reduced dosage need of the drugs with resultant minimal untoward effects, quicker realization of benefits, minimal invasiveness/pain involved and not the least it is an outpatient procedure. Despite so many plus points, it has to be noted that currently there is a dearth of rigorous scientific studies to prove its efficacy and safety. Further, the average cost per session alone ranges from 200 USD to 600 USD. Source

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