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Negi H.,National Institute of Pharmaceutical Education and Research | Sarkar M.,Indira Gandhi Medical College and Hospital | Raval A.D.,West Virginia University | Pandey K.,Rajendra Memorial Research Institute of Medical Sciences | And 2 more authors.
Indian Journal of Medical Research | Year: 2014

Background & objectives: Although depression is a significant co-morbid condition in chronic illnesses, little is known about the prevalence or risk factors for depressive symptoms in patients with chronic obstructive pulmonary disease (COPD) in India. This study was undertaken to investigate the presence and risk factors of depression in the COPD patients attending a tertiary care health facility in north India. Methods: COPD was classified according to GOLD stages based on forced expiratory volume in one second (FEV1) in 126 stable patients. Depression was examined by administering the nine-item Hindi version of Patient Health Questionnaire-9 (PHQ-9). Linear regression model was used to examine association between predictor variables and risk of depression with adjustment of age and sex. Cronbach alpha was calculated to assess internal consistency of PHQ-9. Results: In the study population as whole, 33.3 per cent patients showed moderate to severe depressive symptoms whereas 20.6 per cent patients had major depressive disorder on PHQ-9 Scale. Educational and occupational status, body mass index, FEV1, respiratory symptoms, physical impairment and dyspnoea were found to be potential predictors of depression in COPD patients. Interpretation & conclusions: One fifth of the patients with COPD had severe symptoms of related to depression, which was especially higher with severity of COPD. Hence, the patients with COPD should focus on management of these two conditions. Further, future studies should be conducted to assess the role of depression management and timely treatment of it in patients with COPD. Source


Kavimani M.,Bharath University | Suba Anandhi K.,Indira Gandhi Medical College and Hospital | Jebakani C.F.,Madras Medical College and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2014

The median nerve is a nerve in humans and other animals in the upper limb. It is one of the five main nerves originating from the brachial plexus. The median nerve is formed from contributions from the lateral and medial cords of the brachial plexus, originating from ventral roots of C5, C6 & C7 (lateral cord) and C8 & T1 (medial cord). The present study was done by dissecting forearm and palm in the human cadaver available in the Institute of Anatomy, Madras medical college, Chennai. In the present study on 15 specimens of upper limb the accessory muscular branch to thenar muscles is seen in 20%. Of which in 10% the accessory branch to the thenar muscles is arising proximal to the flexor retinaculum from the main nerve trunk. In 5% the accessory branch to the thenar muscles is arising distal to the flexor retinaculum from the proper digital branch to the lateral sides of the thumb. Source


Kavimani M.,Bharath University | Suba Anandhi K.,Indira Gandhi Medical College and Hospital | Jebakani C.F.,Madras Medical College
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2016

Aim of this study to detail discussing the anatomy of caecum in adult cadavers. Anatomical and topographical variations of the caecum are known to occur. Anatomical variations in caecum also have been observed. The study was carried out on 50 adult cadavers over a period of 2 years. The anatomy of caecum was studied in detail. 50 embalmed cadavers (30 male and 20 female) were dissected to study position, shape, length and width of caecum. The study was done in the department of anatomy of madras medical college, Chennai. Out of 50 adult cadavers in 48 cases the caecum was found in right iliac fossa, but only in two cases it was situated in the sub-hepatic region. Out of 50 adult cadavers in 46 cases shape of caecum were normal adult type(Ampullary), 2 cases were of exaggerated variety, one case was of infantile type, and one case was of fetal type. The length of caecum in 30 adult males was 6.0 cm± 0.96 SD[range: 4.0-9.0 cm] and width was 6.1cm ± 1.0 SD[range:3.5-12.0 cm]. The length of caecum in 20 adult females was 5.9 cm± 0.37 SD [range: 5.5-6.5 cm] and width was 6.6cm ± 0.38 SD [range:5.5-6.7 cm]. The knowledge of anatomy of caecum is of significant importance during surgical and radiological procedure. Source


Negi H.,National Institute of Pharmaceutical Education and Research | Sarkar M.,Indira Gandhi Medical College and Hospital | Raval A.,West Virginia University | Pandey K.,Rajendra Memorial Research Institute of Medical Sciences | Das P.,National Institute of Pharmaceutical Education and Research
Journal of Postgraduate Medicine | Year: 2014

Background and Objectives: Chronic obstructive pulmonary disease (COPD) is a major health problem in India and constitutes an important cause of mortality and morbidity. A cross-sectional study was undertaken to assess health-related quality of life (HRQL) and its determinants in patients with COPD from India. Materials and Methods: A total of 126 patients (73.81% male) were enrolled using convenient sampling prospectively in this cross-sectional study. Eligible patients were assessed for socioeconomic status, anthropometric measures, COPD severity, dyspnea and health status using the Hindi version of St George's Respiratory Questionnaire (SGRQ). Linear regression model was used to examine the association between risk factors and HRQL score (a higher score indicating poorer HRQL), adjusting for age and sex. Results: The mean total score for SGRQ in the patients was 52.66 ± 12.89, indicating a marked impairment of HRQL. Impairment was associated with the severity of airway obstruction, but within each Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage, the variation (SD) was wide [stage I: 47.8 ± 12.3 (n = 14); stage II: 49.28 ± 11.69 (n = 47); stage III: 53.47 ± 11.69 (n = 44); stage IV: 61.75 ± 14.14 (n = 21)]. A regression analysis showed that body mass index, forced expiratory volume in 1 s (FEV 1 ), dyspnea grade, and depression were associated with poor HRQL. Conclusion: HRQL of COPD patients was significantly impaired across stages. Marked impairment of HRQL was found even in patients with mild disease. Source


Kavimani M.,Bharath University | Suba Anandhi K.,Indira Gandhi Medical College and Hospital | Jebakani C.F.,Madras Medical College and Hospital
Research Journal of Pharmaceutical, Biological and Chemical Sciences | Year: 2015

Carpal tunnel syndrome (CTS) is a median entrapment neuropathy that causes paresthesia, pain, numbness, and other symptoms in the distribution of the median nerve due to its compression at the wrist in the carpal tunnel. The mechanism is not completely understood but can be considered compression of the median nerve traveling through the carpal tunnel. It appears to be caused by a combination of genetic and environmental factors. Some of the predisposing factors include: diabetes, obesity, pregnancy, hypothyroidism, and heavy manual work or work with vibrating tools. There is, however, little clinical data to prove that lighter, repetitive tasks can cause carpal tunnel syndrome. Other disorders such as bursitis and tendinitis have been associated with repeated motions performed in the course of normal work or other activities. 30 years women came to my clinic for infertility evaluation.Her husband semen analysis is normal.After detailed investigation in chennai government hospital she diagnosed as carpal tunnel syndrome.We are discussing the details of this syndrome in this article. Source

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