Bloomington, IN, United States
Bloomington, IN, United States

Indiana University is a multi-campus public university system in the state of Indiana, United States. Indiana University has a combined student body of more than 110,000 students, including approximately 43,000 students enrolled at the Indiana University Bloomington campus and approximately 31,000 students enrolled at the Indiana University – Purdue University Indianapolis campus. Wikipedia.


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Patent
Bolder Biotechnology, Inc., Indiana University and Medical College of Wisconsin | Date: 2016-09-19

Methods and compositions comprising hematopoietic growth factor proteins and/or protein analogs thereof and/or combinations thereof and angiotensin converting enzyme inhibitors to treat the acute and long term adverse effects of radiation exposure in subjects who have been or will be exposed to radiation are disclosed.


Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.


Patent
Indiana University and Janssen Biotech Inc. | Date: 2015-05-21

This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37s antibacterial activity.


Patent
French Institute of Health, Medical Research, Assistance Publique Hopitaux De Paris and Indiana University | Date: 2016-11-17

The present invention relates to methods for preventing and treating chronic kidney disease (CKD).


Disclosed herein are materials and methods for creating and/or isolating variants of yeasts especially variants of Saccharomyces cerevisiae that can grow on sugars other than D-glucose in the presence of amounts of 2-deoxy-glucose and or D-glucose that inhibit most strains of yeast from growing on sugars other than D-glucose. Selection media that can be used to isolate such variants include pentose sugars such as D-xylose, L-glutamine and 2-deoxy-glucose. Mutations in the Grr1 and Red genes in some strains also produce variants that can grow on sugars including the pentose D-xylose in the presence of 2-deoxy-glucose.


Patent
Indiana University | Date: 2016-08-05

Methods for modulating inflammation using progesterone metabolites are disclosed. More particularly, methods of administering progesterone metabolites, 6-hydroxyprogesterone (6-OHP) and 16-hydroxyprogesterone (16-OHP) are disclosed for mitigating inflammation in various tissue types in the body.


A method and system for determining depth of an image using a single imager and a lens having a variable focal length is provided. The system comprises a microfluidic lens having a variable focal length controlled by a lens controller and an imager receiving an image of an object from the lens, wherein the imager is configured to receive a first image comprising a first plurality of pixels from the lens at a first focal length and a second image comprising a second plurality of pixels from the lens at a second focal length, the second focal length being different than the first focal length, non-volatile memory, wherein the first image and the second image are stored in the non-volatile memory, a depth module configured to determine a distance between the lens and the object based by a comparison of the first image of the object and the second image of the object.


Expression of Forkhead-box protein A1 (FOXA1), a transcription factor important for the normal development of the prostate gland is thought to be controlled by steroid hormones and GATA-3. Expression of FOXA1, GATA-3 and androgen receptor (AR) was retrospectively analyzed by immunohistochemistry (IHC) in a series of 80 primary tumors and 28 metastatic prostate cancers including 15 matched paired samples. High nuclear FOXA1 expression was seen in 19% of primary tumors and 89% of metastatic tumors (p<0.0001). FOXA1 expression correlated positively with tumor size, extra-prostatic extension, angiolymphatic invasion, AR and metastasis but did not correlate with age, tumor stage, Gleason score, presence of PIN or multifocality, seminal vesicle or perineural invasion and status of surgical excision margins. Expression of GATA-3 was not seen in either normal epithelium or tumor. High FOXA1 expression is associated with development of metastatic prostate cancer. Accordingly, FOXA1 expression can be used to classify patients at higher risk for metastases.


Patent
Indiana University and Purdue Research Foundation | Date: 2016-06-30

Apparatus and methods for a MEMS-fabricated variable capacitor. In one embodiment the capacitor is a comb drive comprising a plurality of plates interdigitated with a corresponding blades. As the plates move relative to the blades, the capacitance of the sensor changes. The capacitor is sufficiently sensitive to measure respiratory pressure in an animal.


Patent
Indiana University | Date: 2015-04-14

Virus capsids protect the viral genome and play roles in its delivery and intracellular transport, making them an attractive target for antiviral therapeutics. The difficulty in targetting capsid assembly is to identify molecules that interfere with the weak protein-protein interactions that drive the reaction. We have developed an in vitro assay for capsid assembly that works on a range of viruses at biologically relevant protein concentrations to facilitate screening large libraries of chemicals for lead compounds.


Grant
Agency: Cordis | Branch: H2020 | Program: RIA | Phase: EINFRA-1-2014 | Award Amount: 8.65M | Year: 2015

Over the last decade, the European Grid Infrastructure (EGI) has built a distributed computing and data infrastructure to support over 21,000 researchers from many disciplines with unprecedented data analysis capabilities. EGI builds on the European and national investments and relies on the expertise of EGI.eu - a not-for-profit foundation that provides coordination to the EGI Community, including user groups, EGI.eu participants in the EGI Council, and the other collaborating partners. The mission of EGI-Engage is to accelerate the implementation of the Open Science Commons vision, where researchers from all disciplines have easy and open access to the innovative digital services, data, knowledge and expertise they need for their work. The Open Science Commons is grounded on three pillars: the e-Infrastructure Commons, an ecosystem of key services; the Open Data Commons, where any researcher can access, use and reuse data; and the Knowledge Commons, in which communities have shared ownership of knowledge and participate in the co-development of software and are technically supported to exploit state-of-the-art digital services. EGI-Engage will expand the capabilities offered to scientists (e.g. improved cloud or data services) and the spectrum of its user base by engaging with large Research Infrastructures (RIs), the long-tail of science and industry/SMEs. The main engagement instrument will be a network of eight Competence Centres, where National Grid Initiatives (NGIs), user communities, technology and service providers will join forces to collect requirements, integrate community-specific applications into state-of-the-art services, foster interoperability across e-Infrastructures, and evolve services through a user-centric development model. The project will also coordinate the NGI efforts to support the long-tail of science by developing ad hoc access policies and by providing services and resources that will lower barriers and learning curves.


Grant
Agency: Cordis | Branch: FP7 | Program: CP-FP | Phase: HEALTH.2013.2.2.1-5 | Award Amount: 8.03M | Year: 2013

Amputation of a limb may result from trauma or surgical intervention. The amputation traumatically alters the body image, but often leaves sensations that refer to the missing body part. In 50-80% amputees, neuropathic pain develops, also called phantom limb pain (PLP). Both peripheral and central nervous system factors have been implicated as determinants of PLP. Also, PLP may be triggered by physical (changes in the weather) and psychological factors (emotional stress). Recent evidence suggests that PLP may be intricately related to neuroplastic changes in the cortex, and that these changes may modulated by providing sensory input to the stump or amputation zone. However, the understanding of why PLP occurs is still poor, the basic research results have not been tested on a large scale in the clinic, and there are no fully effective, long-term treatments readily available on the market. We aim to challenge the status-quo of PLP therapy by offering technological solutions that will invasively or non-invasively induce natural, meaningful sensations to the amputee to restore the neuroplastic changes in the cortex and thereby control and alleviate PLP. We will assess the effect of cortical neuroplastic, psychological and cognitive components of pain and integrate the knowledge into clinical guidelines. The proposed work directly targets the HEALTH.2013.2.2.1-5 topic. The consortium will build solutions based on existing technologies emerging from previous EU funded research which are presently only available in experimental settings. We believe that implementation of proposed work will be the cornerstone needed to exploit, validate and translate the basic research results into clinical applications and provide long-term, patient-specific solutions to a large group of patients suffering from PLP. The work will assist to improve the quality of life for amputees suffering from phantom limb pain and is of high socio-economic relevance to the EU.


Evans J.P.,University of North Carolina at Chapel Hill | Meslin E.M.,Indiana University | Marteau T.M.,King's College London | Caulfield T.,University of Alberta
Science | Year: 2011

Unrealistic expectations and uncritical translation of genetic discoveries may undermine other promising approaches to preventing disease and improving health.


Patent
University of Notre Dame and Indiana University | Date: 2015-05-13

A genetic biomarker panel is provided for prognosing late onset ER+ breast cancer relapse, in a breast cancer survivor patient. Kits are also provided for measuring levels or the presence of an identified panel of genetic biomarkers. Methods are also provided for identifying a breast cancer survivor patient at a relatively high risk of suffering a breast cancer relapse within 8 years of diagnosis, and therefore suitable for treatment with an aggressive chemotherapeutic regimen. The method may also be used for identifying a breast cancer survivor patient not at high risk of suffering a breast cancer relapse within 8 years of diagnosis, and thus not suitable for treatment with an aggressive chemotherapeutic regimen. The genetic biomarker panel includes an oligonucleotide/nucleic acid sequence specific for the following genes: MKI67, SPAG5, ESPL1, PLK1, or a genetic panel for MKI67, SPAG5, ESPL1, PLK1 and PGR.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2011.2.3-2 | Award Amount: 4.00M | Year: 2012

The European Energy Research Alliance (EERA) together with some high-impact industry partners addresses the call proposing an integrated and validated design tool combining the state-of-the-art wake, yield and electrical models available in the consortium, as a plug-in architecture with possibility for third party models. To decrease uncertainties around wind farm wake predictions, a small measurement campaign together with the new data available from the industry partners will enable better tuning, and eventually better modelling of the far-field of wind farm wakes. With the large amount of offshore wind farms to be built in the next years, clusters of wind farms will appear at favourable locations, like in the German Bight and Dogger Bank. Large arrays of floating wind farms planned near long-distance grid cables independent of water depth will also start to appear in the next years. The planning and design of these clusters pose new challenges with regards to the siting of the connected wind farms, the design of the interconnecting grid structure and the integration of the large amount of power into the electricity supply systems. The concept of the EERA-DTOC project is to combine this expertise in a common integrated software tool for the optimised design of offshore wind farms and wind farm clusters acting as wind power plants. The only point less well known, due to the lack of good data so far, is the behaviour of the wind farm wake, in particular far-field wake. Therefore, a small measurement campaign is planned and collection of lidar data and high-resolution satellite images to get better data. Key industry actors working as end users of the software will help in the design of the tool, and will afterwards verify the performance of the tool using their own data and test cases.


Walczak C.E.,Indiana University | Cai S.,Indiana University | Khodjakov A.,New York State Department of Health
Nature Reviews Molecular Cell Biology | Year: 2010

For over a century, scientists have strived to understand the mechanisms that govern the accurate segregation of chromosomes during mitosis. The most intriguing feature of this process, which is particularly prominent in higher eukaryotes, is the complex behaviour exhibited by the chromosomes. This behaviour is based on specific and highly regulated interactions between the chromosomes and spindle microtubules. Recent discoveries, enabled by high-resolution imaging combined with the various genetic, molecular, cell biological and chemical tools, support the idea that establishing and controlling the dynamic interaction between chromosomes and microtubules is a major factor in genomic fidelity. © 2010 Macmillan Publishers Limited. All rights reserved.


Jones J.A.,University of Pennsylvania | Lutz S.T.,Blanchard Valley Regional Cancer Center | Chow E.,University of Toronto | Johnstone P.A.,Indiana University
CA Cancer Journal for Clinicians | Year: 2014

When delivered with palliative intent, radiotherapy can help to alleviate a multitude of symptoms related to advanced cancer. In general, time to symptom relief is measured in weeks to months after the completion of radiotherapy. Over the past several years, an increasing number of studies have explored rates of radiotherapy use in the final months of life and have found variable rates of radiotherapy use. The optimal rate is unclear, but would incorporate anticipated efficacy in patients whose survival allows it and minimize overuse among patients with expected short survival. Clinician prediction has been shown to overestimate the length of survival in repeated studies. Prognostic indices can provide assistance with estimations of survival length and may help to guide treatment decisions regarding palliative radiotherapy in patients with potentially short survival times. This review explores the recent studies of radiotherapy near the end of life, examines general prognostic models for patients with advanced cancer, describes specific clinical circumstances when radiotherapy may and may not be beneficial, and addresses open questions for future research to help clarify when palliative radiotherapy may be effective near the end of life. © 2014 American Cancer Society.


Patent
Indiana University and Hoffmann-La Roche | Date: 2013-06-18

Provided herein are glucagon analogs which exhibit potent activity at the GIP receptor, and, as such are contemplated for use in treating diabetes and obesity. In exemplary embodiments, the glucagon analog of the present disclosures exhibit an EC50 at the GIP receptor which is within the nanomolar or picomolar range.


Animal welfare is one of the topics that has consistently ranked on the top of items brought to the attention of governmental organizations and politicians across European countries. Concerns about animal welfare among European citizens are founded in well thought expectations from governments, industry and other stakeholders. The tremendous public scrutiny on animal welfare related issues put excessive pressure on lawmakers who are expected to offer rapid and effective solutions to perceived animal welfare problems. The need for rapid responses to address animal welfare issues has, oftentimes, pressured animal welfare scientists to develop suboptimal criteria to assess animal welfare and created a gap between fundamental scientific questions in this new scientific discipline and the applied aspects needed to attend the immediate public concerns. In this proposal our goal is to rescue the balance on the need for a science based approach to investigate animal welfare questions. We will develop and test animal based welfare, including pain, indicators in sheep, goats, horses, donkeys and turkeys. In addition we will engage veterinarians to study the relationship between diseases and animal welfare. We will also address more fundamental questions measuring husbandry factors that may affect pre-natal programming of adaptive strategies that my compromise the validity and reliability of welfare indicators. Finally we will integrate research, teaching and outreach activities through the Global Research and Teaching School (Hub) in Animal Welfare Science in order to promote sustainability fostering long-term competitiveness in the European animal industry through a transparent and inclusive relationship among stakeholders.


Grant
Agency: Cordis | Branch: FP7 | Program: CP | Phase: ENERGY.2013.6.1.1 | Award Amount: 4.10M | Year: 2013

The main objective of the proposed project is to develop a generic UCG-CCS site characterisation workflow, and the accompanying technologies, which would address the dilemma faced by the proponents of reactor zone CO2 storage, and offer technological solutions to source sink mismatch issues that are likely to be faced in many coalfields. This objective will be achieved through integrated research into the field based technology knowledge gaps, such as cavity progression and geomechanics, potential groundwater contamination and subsidence impacts, together with research into process engineering solutions in order to assess the role/impact of site specific factors (coal type, depth/pressure, thickness, roof and floor rock strata, hydrology) and selected reagents on the operability of a given CO2 emission mitigation option in a coalfield. CO2 storage capacity on site for European and international UCG resources will be assessed and CO2 mitigation technologies based on end use of produced synthetic gas will be evaluated. The technology options identified will be evaluated with respect to local and full chain Life Cycle environmental impacts and costs. The project takes a radical and holistic approach to coupled UCG-CCS, and thus the site selection criteria for the coupled process, considering different end-uses of the produced synthetic gas, covering other options beyond power generation, and will evaluate novel approaches to UCG reagent use in order to optimise the whole process. This approach aims at minimising the need for on-site CO2 storage capacity as well as maximising the economic yield of UCG through value added end products, as well as power generation, depending on the local coalfield and geological conditions.


Herein is reported an Fc-region fusion polypeptide or Fc-region conjugate comprising one to four incretin receptor ligand polypeptides and a variant human Fc-region with a mutation of the amino acid residue at position 329 and at least one further mutation of at least one amino acid selected from the group comprising amino acid residues at position 228, 233, 234, 235, 236, 237, 297, 318, 320, 322 and 331 to a different residue, wherein the residues in the Fc-region are numbered according to the EU index of Kabat and its use as a medicament.


Patent
Indiana University and Hoffmann-La Roche | Date: 2014-12-19

Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region, wherein at least one of the incretin receptor ligand polypeptides comprises an amino acid that is covalently conjugated to a lipid, and wherein each of the one, two, three or four incretin receptor ligand polypeptides is covalently conjugated by a peptide bond to a terminus of the human immunoglobulin Fc-region, whereby to each terminus of the human immunoglobulin Fc-region only a single incretin receptor ligand polypeptide is conjugated.


Bruza P.D.,Queensland University of Technology | Wang Z.,Ohio State University | Busemeyer J.R.,Indiana University
Trends in Cognitive Sciences | Year: 2015

What type of probability theory best describes the way humans make judgments under uncertainty and decisions under conflict? Although rational models of cognition have become prominent and have achieved much success, they adhere to the laws of classical probability theory despite the fact that human reasoning does not always conform to these laws. For this reason we have seen the recent emergence of models based on an alternative probabilistic framework drawn from quantum theory. These quantum models show promise in addressing cognitive phenomena that have proven recalcitrant to modeling by means of classical probability theory. This review compares and contrasts probabilistic models based on Bayesian or classical versus quantum principles, and highlights the advantages and disadvantages of each approach. © 2015 Elsevier Ltd.


Day R.N.,Indiana University | Davidson M.W.,Florida State University
BioEssays | Year: 2012

The discovery and engineering of novel fluorescent proteins (FPs) from diverse organisms is yielding fluorophores with exceptional characteristics for live-cell imaging. In particular, the development of FPs for fluorescence (or Förster) resonance energy transfer (FRET) microscopy is providing important tools for monitoring dynamic protein interactions inside living cells. The increased interest in FRET microscopy has driven the development of many different methods to measure FRET. However, the interpretation of FRET measurements is complicated by several factors including the high fluorescence background, the potential for photoconversion artifacts and the relatively low dynamic range afforded by this technique. Here, we describe the advantages and disadvantages of four methods commonly used in FRET microscopy. We then discuss the selection of FPs for the different FRET methods, identifying the most useful FP candidates for FRET microscopy. The recent success in expanding the FP color palette offers the opportunity to explore new FRET pairs. © 2012 WILEY Periodicals, Inc.


Radicchi F.,Indiana University | Radicchi F.,Rovira i Virgili University | Arenas A.,Rovira i Virgili University | Arenas A.,Institute Catala Of Paleoecologia Humana I Evolucio Social
Nature Physics | Year: 2013

Our world is linked by a complex mesh of networks through which information, people and goods flow. These networks are interdependent on each other, and present structural and dynamical features different from those observed in isolated networks. Although examples of such dissimilar properties are becoming more abundant - such as in diffusion, robustness and competition - it is not yet clear where these differences are rooted. Here we show that the process of building independent networks into an interconnected network of networks undergoes a structurally sharp transition as the interconnections are formed. Depending on the relative importance of inter- and intra- layer connections, we find that the entire interdependent system can be tuned between two regimes: in one regime, the various layers are structurally decoupled and they act as independent entities; in the other regime, network layers are indistinguishable and the whole system behaves as a single-level network. We analytically show that the transition between the two regimes is discontinuous even for finite-size networks. Thus, any real-world interconnected system is potentially at risk of abrupt changes in its structure, which may manifest new dynamical properties. © 2013 Macmillan Publishers Limited.


Lysaker P.H.,Roudebush Medical Center 116A | Lysaker P.H.,Indiana University | Dimaggio G.,Centro Of Terapia Metacognitiva Interpersonale
Schizophrenia Bulletin | Year: 2014

Models of schizophrenia, which focus exclusively on discrete symptoms and neurocognitive deficits, risk missing the possibility that a core feature of the disorder involves a reduced capacity to construct complex and integrated representations of self and others. This column details a new methodology that has been used to assess deficits in the metacognitive abilities that allow persons to form complex ideas about themselves and others and to use that knowledge to respond to psychosocial challenges in schizophrenia. Evidence is summarized supporting the reliability and validity of this method, as well as links this work has revealed between metacognition and psychosocial outcomes. It is suggested that this work points to the need to develop interventions which move beyond addressing symptoms and specific skills, and assist persons to recapture lost or atrophied metacognitive capacity and so form the kind of ideas about themselves and others needed, to move meaningfully toward recovery. © The Author 2014. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved.

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