Indiana University is a multi-campus public university system in the state of Indiana, United States. Indiana University has a combined student body of more than 110,000 students, including approximately 43,000 students enrolled at the Indiana University Bloomington campus and approximately 31,000 students enrolled at the Indiana University – Purdue University Indianapolis campus. Wikipedia.
Indiana University | Date: 2017-04-19
A method and apparatus for extracting tissue samples are disclosed herein. An example apparatus disclosed herein includes a first sidewall and a second sidewall spaced apart from the first sidewall. The example apparatus also includes a track to receive a blade between the first sidewall and the second sidewall. The track is to guide the blade to penetrate skin of a patient to a predetermined depth of invasion.
Indiana University and Assembly Biosciences Inc. | Date: 2017-03-15
Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
Indiana University | Date: 2017-04-18
System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subjects skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals from the signal detector, and apply a filter to the received electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subjects skin.
Indiana University | Date: 2017-08-02
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
Indiana University | Date: 2017-08-23
Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.
Indiana University | Date: 2017-01-18
The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
Indiana University | Date: 2017-01-03
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a proein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment.
Indiana University and Assembly Biosciences Inc. | Date: 2017-01-18
ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
Sporns O.,Indiana University
Current Opinion in Neurobiology | Year: 2013
Network studies of large-scale brain connectivity have begun to reveal attributes that promote the segregation and integration of neural information: communities and hubs. Network communities are sets of regions that are strongly interconnected among each other while connections between members of different communities are less dense. The clustered connectivity of network communities supports functional segregation and specialization. Network hubs link communities to one another and ensure efficient communication and information integration. This review surveys a number of recent reports on network communities and hubs, and their role in integrative processes. An emerging focus is the shifting balance between segregation and integration over time, which manifest in continuously changing patterns of functional interactions between regions, circuits and systems. © 2013 Elsevier Ltd.
Kaplan M.H.,Indiana University
Immunological Reviews | Year: 2013
CD4+ T-helper cells regulate immunity and inflammation through the acquisition of potential to secrete specific cytokines. The acquisition of cytokine-secreting potential, in a process termed T-helper cell differentiation, is a response to multiple environmental signals including the cytokine milieu. The most recently defined subset of T-helper cells are termed Th9 and are identified by the potent production of interleukin-9 (IL-9). Given the pleiotropic functions of IL-9, Th9 cells might be involved in pathogen immunity and immune-mediated disease. In this review, I focus on recent developments in understanding the signals that promote Th9 differentiation, the transcription factors that regulate IL-9 expression, and finally the potential roles for Th9 cells in immunity in vivo. © 2013 John Wiley & Sons A/S.