Indiana University is a multi-campus public university system in the state of Indiana, United States. Indiana University has a combined student body of more than 110,000 students, including approximately 43,000 students enrolled at the Indiana University Bloomington campus and approximately 31,000 students enrolled at the Indiana University – Purdue University Indianapolis campus. Wikipedia.
Indiana University and Assembly Biosciences Inc. | Date: 2017-03-15
Described herein are methods for identifying compounds useful for the treatment of infection by hepatitis B virus (HBV) and for identifying compounds useful for the same.
Indiana University | Date: 2017-04-19
A method and apparatus for extracting tissue samples are disclosed herein. An example apparatus disclosed herein includes a first sidewall and a second sidewall spaced apart from the first sidewall. The example apparatus also includes a track to receive a blade between the first sidewall and the second sidewall. The track is to guide the blade to penetrate skin of a patient to a predetermined depth of invasion.
Indiana University | Date: 2016-12-13
Functionalized graphene comprising graphene, a metal dispersed throughout the graphene, wherein the metal comprises Pt, Rh, Pd, Ag, Au, Ni, Os, Ir, alloys thereof, oxides thereof, or mixtures thereof, and a first functional group covalently bonded to the graphene, wherein the first functional group comprises sulfonate, SO_(3)^(), Carboxylate, COO^(), a tertiary amine, NR_(3)^(+), where R is H, alkyl, aryl, or combinations thereof, polybenzimidazole (PBI), poly(ethylene oxide) (PEO), polyphenylene oxide (PPO), polyaniline, or mixtures thereof are disclosed. Methods of manufacture are also disclosed.
Indiana University | Date: 2017-01-03
Targeting uncontrolled cell proliferation and resistance to DNA damaging chemotherapeutics with at least one reagent has significant potential in cancer treatment. Replication Protein A, the eukaryotic single-strand (ss) DNA binding protein, is essential for genomic maintenance and stability via roles in both DNA replication and repair. Reported herein are small molecules that inhibits the in vitro, in vivo, and cellular ssDNA binding activity of RPA, thereby disrupting the eukaryotic cell cycle, inducing cytotoxicity and increasing the efficacy of chemotherapeutic agents damage DNA, and/or disrupt its replication and/or function. These results provide new insights into the mechanism of RPA-ssDNA interactions in chromosome maintenance and stability. This represents a molecularly targeted eukaryotic DNA binding inhibitor and demonstrates the utility of targeting a proein-DNA interaction as a means of studying the cell cycle and providing a therapeutic strategy for cancer treatment.
Indiana University | Date: 2016-08-19
Methods of manufacturing comprising placing a mixture comprising sulfur powder, a carbon nanotube, an alcohol soluble binder, and a solvent into a cast and removing a solvent from the mixture to form an electrode are disclosed. Electrodes and batteries comprising sulfur, a carbon nanotube, and an alcohol soluble binder are also disclosed.
Indiana University | Date: 2017-01-18
The present disclosure relates generally to methods and compositions useful in cell and tissue biology and therapeutics. In particular, an in vitro method for differentiating pluripotent cells into endothelial colony forming cell-like cells (ECFC-like cells) is provided. A purified human cell population of NRP-1+CD31+ ECFC-like cells is provided, wherein at least some of the cells in the population have a high proliferation potential. Therapeutic and test agent screening methods for using the cell populations of the present disclosure are provided.
Indiana University and Assembly Biosciences Inc. | Date: 2017-01-18
ABSTRACT The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.
Indiana University and Scripps Research Institute | Date: 2016-10-06
In addition to containing and protecting the viral genome, the capsid (protein shell) of hepatitis B virus (HBV) plays critical roles in the viral life cycle including regulation of intracellular trafficking and nucleic acid metabolism. Substituted pyrimidine modulators of the assembly of the HBV capsid structure and methods for their use are described.
Indiana University | Date: 2017-04-18
System and methods for monitoring and/or controlling nerve activity in a subject are provided. In one embodiment, a system includes electrodes configured to be placed proximate to a subjects skin, and a signal detector configured to detect electrical signals using the electrodes. The system also includes a signal processor configured to receive the electrical signals from the signal detector, and apply a filter to the received electrical signals to generate filtered signals, the filter configured to attenuate at least signals having frequencies corresponding to heart muscle activity during a heartbeat. The signal processor is also configured to identify a skin nerve activity using the filtered signals, estimate a sympathetic nerve activity using the identified skin nerve activity, and further to generate a report indicative of the estimated sympathetic nerve activity. In some aspects, the system further includes a signal generator to deliver the electrical stimulation to the subjects skin.
Indiana University | Date: 2017-08-02
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half-lives and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.