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Ghāziābād, India

Bisht A.,Indian Pharmacopoeia Commission | Singh S.,National Institute of Biologicals | Marwaha N.,Jawaharlal Institute of Postgraduate Medical Education & Research
Asian Journal of Transfusion Science

A centralized hemovigilance program to assure patient safety and to promote public health has been launched for the first time in India on Dec 10, 2012 in 60 medical colleges in the first phase along with a well-structured program for monitoring adverse reactions associated with blood transfusion and blood product administration. National Institute of Biologicals (NIB) will be the National Coordinating Centre for Hemovigilance. This program will be implemented under overall ambit of Pharmacovigilance Program of India (PvPI), which is being coordinated by Indian Pharmacopoeia Commission (IPC). All medical colleges of the country will be enrolled in this program by the year 2016 in order to have a National Centre of Excellence for Hemovigilance at NIB, which will act as a global knowledge platform. Source

Kalaivani M.,Indian Pharmacopoeia Commission
Journal of Food Science and Technology

In the present study, anti-diabetic activity and nephroprotective effect of MMFR was evaluated by using STZ-induced diabetic rats. Administration of MMFR at 100 and 200 mg/kg bw showed significant (P < 0.01) anti-hyperglycemic activity by lowering blood glucose level, HbA1C and increasing body weight. Altered lipid profiles in diabetic rats were restored to normal level on treatment with MMFR and showed significant (P < 0.01) decrease in the elevated levels of biochemical parameters. MMFR produced significant (P < 0.01) improvement in antioxidant levels in kidney. Food safety of MFR produced by using mutant Monascus purpureus 254 (MMFR) was evaluated for genotoxicity and oral acute toxicity. In Ames mutagenicity assay MMFR doesn’t showed any toxicity to the test strain S. typhimurium till 5 mg/plate. Acute toxicity study also recorded no toxicity till the dose of 5,000 mg/kg bw. The study concluded that MMFR, not only possess anti-diabetic activity but also prevents nephropathy and hypercholesterolemia due to diabetes. © 2013, Association of Food Scientists & Technologists (India). Source

Kalaivani M.,Indian Pharmacopoeia Commission
Journal of Food Science and Technology

Designer foods are normal foods fortified with health promoting ingredients. These foods are similar in appearance to normal foods and are consumed regularly as a part of diet. In this article we have reviewed the global regulatory status and benefits of available designer foods such as designer egg, designer milk, designer grains, probiotics, designer foods enriched with micro and macronutrients and designer proteins. Designer foods are produced by the process of fortification or nutrification. With the advances in the biotechnology, biofortification of foods using technologies such as recombinant DNA technology and fermentation procedures are gaining advantage in the industry. The ultimate acceptability and extensive use of designer foods depend on proper regulation in the market by the regulatory authorities of the country and by creating consumer awareness about their health benefits through various nationwide programs. © 2012 Association of Food Scientists & Technologists (India). Source

Dye degradation is presently an important area of scientific activity. Today, most wastewater treatment makes use of the conventional processes in the presence and action of a native microbial population. However, the potential natural microbial population and genetically engineered microorganisms (GEMs) could successfully bioaugment dye biotreatment systems to enhance efficiency. Consequently, treatment facilities are designed to maintain a high density of the desired microbial population to satisfy the bioremediation demand. Nevertheless, malefactions resulting in a decrease of activity are frequent. To better understand the function of the bacterial community, a full description of the microbial population is required. The prominent task of the microbiologist is to compare the structure, dynamics, and function of the existing microbial populations. Even though the last decade has seen a revolution in microbiology, microbial population monitoring still relies on the tools that were available at the beginning of this century. It is the goal of this review to explain the potential and importance of the newly available molecular tools for analyzing microbial populations. Molecular techniques over the last few decades have revealed an enormous reservoir of unexplained microbes. This large genetic diversity has an immense potential to be used as a resource for the development of novel biotransformations, bioremediation processes, and bioenergy generation. This paper will review bioremediation and the exploration of genetic information from microbial populations for efficiency enhancement. © 2011 Published by NRC Research Press. Source

Pandey M.K.,Indian Pharmacopoeia Commission | Singh G.N.,Indian Pharmacopoeia Commission | Sharma R.K.,Pharmacopoeia Laboratory of Indian Medicine | Lata S.,Mmh College
Journal of Applied Pharmaceutical Science

Eclipta alba (L.) Hassk is small branched annual herbaceous plant with a long history of traditional medicines uses in many countries especially in tropical and subtropical regions. The herb has been known for its curative properties and has been utilized as antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic, antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. A wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids, polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts and metabolites from this plant have been known to possess pharmacological properties. The present study confirmed the antibacterial potential of aerial parts extracts of Eclipta alba in solvents like acetone, ethanol, methanol, aqueous and hexane against selected gram positive and gram negative bacterial species. The antibacterial studies were done by agar well diffusion methods. The MIC and MBC methods were also used. Hexane extract of showed Eclipta alba high antibacterial activity against S.aureus, B.cereus, E.coli, S.typhi, K.pneumoniae,S.pyogenes and P.aeruginosa. whereas acetone, ethanol, methanol and aqueous extracts showed intermediate activity against S.aureus, B.cereus, E.coli, S.typhi, K.pneumoniae, P.aeruginosa, P.mirabilis and S.pyogenes. The inhibitory activities of all the extracts reported were compared with standard antibiotics (Ciprofloxacin 25 μg/ml). An MIC of 90.0μg/ml shown by E.coli and S.aureus was considered to be the best (below 100μg/ml), an MIC of 125.0μg/ml shown by E.coli, K.pneumoni, P.mirabilis and S.typhi was considered to be better (100-500μg/ml) as such by the action of acetone, ethanol, methanol and hexane extracts on test bacterial spp respectively MIC between (500-1000μg/ml) was considered to be good. The aqueous extracts of Eclipta alba showed good activity against S.pyogenes, B.cereus, E.coli and P.aeruginosa. If the dilution was above 1000μg/ml the extract were considered inactive against S.aureus, K.pneumoniae, P.mirabilis and S.typhi. MBC results were similar to MIC results but in the case of MBC the confirmation was made by absence of growth in culture plates after 24 hrs of incubation at 37°C. A potent antibacterial and hepatoprotective drug could probably be formulated from the plant extract of Eclipta alba to combat the effects of bacterial and hepatotoxic infections. Source

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