Indian Institute of Technology Bombay
Mumbai, India

The Indian Institutes of Technology is a prestigious group of autonomous public engineering and management institutes of India. The IITs are governed by the Institutes of Technology Act, 1961 which has declared them as "institutions of national importance", and lays down their powers, duties, framework for governance etc. The Institutes of Technology Act, 1961 lists sixteen institutes located at Bhubaneswar, Chennai, Delhi, Gandhinagar, Guwahati, Hyderabad, Indore, Jodhpur, Kanpur, Kharagpur, Mandi, Mumbai, Patna, Ropar, Roorkee and Varanasi. Each IIT is an autonomous institution, linked to the others through a common IIT Council, which oversees their administration. The IITs award degrees ranging from B.Tech to PhD.The IITs have a common admission process for undergraduate admissions. It was called IIT-JEE, which was replaced by Joint Entrance Examination in 2013. The post-graduate level program that awards M.Tech degree in engineering is administered by the older IITs . M.Tech admission is done on the basis of Graduate Aptitude Test in Engineering . In addition to B.Tech and M.Tech programs IITs also award other graduate degrees such as M.Sc in Engineering, Maths, Physics and Chemistry, MBA, PhD etc. Admission to these programs of IITs is done through Common Admission Test, Joint Admission Test for Masters and Common Entrance Examination for Design . Wikipedia.

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News Article | May 4, 2017

Two improved total syntheses of a hot anticancer agent, thapsigargin, could help lead to a commercially viable way to produce the compound. Thapsigargin kills cells by inhibiting an enzyme that controls essential calcium gradients inside cells. Right now, the compound is isolated from a poisonous Mediterranean plant called “deadly carrot.” Søren Brøgger Christensen of the University of Copenhagen, John Isaacs and Samuel R. Denmeade of Johns Hopkins Medicine, and coworkers developed a prodrug version of the molecule called mipsagargin. An enzyme expressed selectively in some cancer cells converts mipsagargin to thapsigargin by cleaving off a peptide side chain. Inspyr Therapeutics is believed to be close to starting Phase III human trials of mipsagargin. For future trials, companies may need a metric ton per year of thapsigargin, Christensen says. Isolating that amount of product from plants is not currently feasible, engineering organisms to make thapsigargin isn’t possible because the biosynthetic pathway is not fully known, and the semisynthesis of the compound in large amounts from a readily available natural product is possible but unproven. That leaves total synthesis. Steven Ley of the University of Cambridge and coworkers developed the first approach in 2007. With 42 steps and less than 1% yield, that synthesis isn’t practical for making large amounts. Groups led by Phil S. Baran of Scripps Research Institute California and P. Andrew Evans of Queen’s University have now independently developed more-efficient syntheses with far fewer steps (ACS Cent. Sci. 2016, DOI: 10.1021/acscentsci.6b00313; J. Am. Chem. Soc. 2017, DOI: 10.1021/jacs.7b01734). The improved practicality of Baran and coworkers’ approach is based in part on using strategic oxidations and introducing stereocenters in a way that avoids the use of expensive chiral ligands or auxiliaries, comments Krishna P. Kaliappan of the Indian Institute of Technology Bombay. And Evans’s group achieved its improved efficiency in part by establishing thapsigargin’s polyoxygenated core with correct stereochemistry relatively early in the synthesis—an approach that could make it easier to prepare analogs for structure-activity relationship studies, Christensen says. There has been debate over the relative yields and number of steps of the two new syntheses, so it is hard to compare the efficiencies of the approaches. But both new syntheses “allow scaling to produce thapsigargin and represent advances in the ability to supply practical quantities for drug discovery,” says Javier Moreno-Dorado of the University of Cádiz.

Indian Institute of Technology Bombay | Date: 2016-01-20

A system and method for decomposing municipal solid waste (MSW) under anaerobic conditions. The system includes a bioreactor landfill with the MSW, a leachate recirculation unit in connection with the bioreactor landfill, a multilevel thermocouple unit, placed inside the bioreactor landfill for monitoring temperature in the bioreactor landfill. Further, the system includes a sensor for monitoring moisture level within the bioreactor landfill. Furthermore, the system includes the leachate recirculation unit configured to initiate recirculation of a leachate, collected from the bioreactor landfill, when temperature in the bioreactor reaches a determined temperature and a determined moisture level.

Indian Institute of Technology Bombay | Date: 2016-11-07

A network capable of being used in a datacenter is described. The network can comprise a set of optical fiber rings, wherein each optical fiber ring carries data traffic on multiple wavelengths, and wherein each optical fiber ring is partitioned into multiple sectors. In some embodiments, each sector in the multiple sectors can comprise: (1) only one add-wavelength-selective-switch (add-WSS) communicatively coupled to only one optical fiber ring in the set of optical fiber rings, wherein the only one add-WSS is used for sending all data traffic that originates from the sector and is destined to other sectors; (2) an add-electro-optical-switch (add-EOS) communicatively coupled to the add-WSS; (3) a set of drop-wavelength-selective-switches (drop-WSSs) communicatively coupled to the set of optical fiber rings, wherein the set of drop-WSSs are used for receiving data traffic from other sectors; and (4) a drop-electro-optical-switch (drop-EOS) communicatively coupled to a drop-WSS in the set of drop-WSSs.

A method for speech enhancement in speech communication devices and more specifically in hearing aids for suppressing stationary and non-stationary background noise in the input speech signal signals is disclosed. The method uses spectral subtraction wherein the noise spectrum is updated using quantile-based estimation without voice activity detection and the quantile values are approximated by dynamic quantile tracking without involving large storage and sorting of past spectral samples. The technique permits use of a different quantile at each frequency bin for noise estimation without introducing processing overheads. The preferred embodiment uses analysis-modification-synthesis based on Fast Fourier transform (FFT) and it can be integrated with other FFT-based signal processing techniques used in the hearing aids and speech communication devices. A noise suppression system based on this method and using hardware with an audio codec and a digital signal processor chip with on-chip FFT hardware is also disclosed.

Indian Institute of Technology Bombay | Date: 2016-08-12

Embodiments herein provide an implantable Flow Streamliner for passively regulating blood streams in a TCPC subject. The implantable Flow Streamliner is configured to split a blood stream from an Inferior Vena Cava (IVC) and a blood stream from a Superior Vena Cava (SVC), without a direct collision between the blood streams. Further, the implantable Flow Streamliner is configured to distribute the blood stream from the IVC containing hepatic nutrients in proportion to a Left Pulmonary Artery (LPA) and a Right Pulmonary Artery (RPA). Further, the implantable Flow Streamliner is configured to distribute the blood stream from the SVC in equal proportion to the LPA and the RPA.

EID PARRY INDIA Ltd and Indian Institute of Technology Bombay | Date: 2016-02-25

The present disclosure includes a spray bottle assembly (100) which provides separate compartments for containing two or more constituents of a formulation, thereby, preventing premixing of the constituents before the first use, hence, increasing shelf life in a hassle-free way. The spray bottle assembly (100) comprises a spray head (200) for discharging the constituents of a formulation stored in the spray bottle assembly (100), a container bottle (300) for storing a passive constituent of the formulation; a storage receptacle (400) coupled with the container bottle (300), wherein said storage receptacle (400) facilitates the storage of an active constituent of the formulation isolated from the passive constituent; and a dispensing means (500) integrated with the storage receptacle (400).

Indian Institute of Technology Bombay | Date: 2016-09-27

The present invention provides targeted polymeric nano-complexes for delivery of drugs such as anti-mitotic agents or anti-cancer agents. The present invention also provides a process for the preparation of such targeted nano-complexes.

Ariel University, Yeda Research, Development Co. and Indian Institute of Technology Bombay | Date: 2015-11-01

A method of precipitating cell membrane fragments from a cell lysate is disclosed. The method comprises contacting the cell lysate with a hydrophobic chelator and a metal ion under conditions that allow precipitation of the cell membrane fragments. Kits for precipitating cell membrane fragments are also disclosed.

Infineon Technologies and Indian Institute of Technology Bombay | Date: 2017-01-11

Tunnel field effect devices and methods of fabricating tunnel field effect devices are described. In one embodiment, the semiconductor device includes a first drain region of a first conductivity type disposed in a first region of a substrate, a first source region of a second conductivity type disposed in the substrate, the second conductivity type being opposite the first conductivity type, a first channel region electrically coupled between the first source region and the first drain region, the first source region underlying a least a portion of the first channel region, and a first gate stack overlying the first channel region.

Joseph R.,Indian Institute of Technology Bombay | Rao C.P.,Indian Institute of Technology Bombay
Chemical Reviews | Year: 2011

The ion and molecular recognition properties of 1, 3-diconjugates of calix[4]arene were studied. These recognitions were carried out in different solvent systems by using various spectroscopy techniques, and in some cases the species of recognition have been demonstrated by single crystal X-ray structure determination and/or by computational modeling studies. An aspect that requires further attention is the aqueous solubility of calix[4]arene conjugates. It is possible to build more binding sites on the calix[4]arene platform by introducing various donor groups in the vicinity of the lower rim phenolic group of calix[4]arene to provide higher coordination for lanthanides and other demanding ions. All of these receptors primarily possesses O- and N-binding centers, but are mostly deprived of carboxylato- and/or thiolato-moieties that may be required to mimic the selective recognition of metal ions by the corresponding apo-proteins.

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