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Kaul M.K.,Indian Institute of Integrative Medicine
Indian Journal of Traditional Knowledge | Year: 2010

Emerging trends of underutilization of high altitude medicinal plants by Indian phytopharmaceutical industry suggest that therapeutic potential of these species has been exploited to a very less extent despite availability of rich traditional knowledge and also greater possibilities of offering novel bioactive compounds. According to a recent estimate only 20% high altitude medicinal plants available in Indian subcontinent (predominantly herbs) are used in drug trade. In India, we often wake to our own therapeutic wisdom only after recognition comes from the west. High altitude herbal medicines offer therapeutics for many disorders like memory loss, osteoporosis, immune and age-related problems, etc. particularly the ones for which no modern medicines are available. Of late, these plants are also reported to offer satisfactory therapies for deadly diseases like AIDS and cancer. As high altitude plants are growing under stressful situations and exposed to high UV radiations, they are reported to have immense potential in biological radioprotection. An attempt has been made to highlight the promise that these stress-tolerant plants hold in alleviating human and veterinary ailments with less side effects. Studies on the characteristics of ethnopharmacological resources in high altitude Northwest Himalayan region revealing use of 154 botanicals in home remedy patterns of 55 common ailments as well as integration of food and medicine in several traditional herbal therapies are discussed and included in the text. Source

Johri R.K.,Indian Institute of Integrative Medicine
Pharmacognosy Reviews | Year: 2011

Cuminum cyminum and Carum carvi are the sources of cumin and caraway seeds respectively, which have been used since antiquity for the treatment of various indications in traditional healing systems in wide geographical areas. Cumin and caraway seeds are rich sources of essential oils and have been actively researched for their chemical composition and biological activities. In recent times (especially during the last 3 years) considerable progress has been made regarding validation of their acclaimed medicinal attributes by extensive experimental studies. In this attempt many novel bioactivities have been revealed. This review highlights the significance of cumin and caraway as potential source of diverse natural products and their medicinal applications. Source

Bharate S.S.,P.A. College | Bharate S.B.,Indian Institute of Integrative Medicine
ACS Chemical Neuroscience | Year: 2012

(Figure Presented) ThermoTRPs, a subset of the Transient Receptor Potential (TRP) family of cation channels, have been implicated in sensing temperature. TRPM8 and TRPA1 are both activated by cooling. TRPM8 is activated by innocuous cooling (<30 °C) and contributes to sensing unpleasant cold stimuli or mediating the effects of cold analgesia and is a receptor for menthol and icilin (mint-derived and synthetic cooling compounds, respectively). TRPA1 (Ankyrin family) is activated by noxious cold (<17 °C), icilin, and a variety of pungent compounds. Extensive amount of medicinal chemistry efforts have been published mainly in the form of patent literature on various classes of cooling compounds by various pharmaceutical companies; however, no prior comprehensive review has been published. When expressed in heterologous expression systems, such as Xenopus oocytes or mammalian cell lines, TRPM8 mediated currents are activated by a number of cooling compounds in addition to menthol and icilin. These include synthetic p-menthane carboxamides along with other class of compounds such as aliphatic/alicyclic alcohols/esters/amides, sulphones/sulphoxides/sulphonamides, heterocyclics, keto-enamines/lactams, and phosphine oxides. In the present review, the medicinal chemistry of various cooling compounds as activators of thermoTRPM8 channel will be discussed according to their chemical classes. The potential of these compounds to emerge as therapeutic agents is also discussed. © 2012 American Chemical Society. Source

Kumar A.,Indian Institute of Integrative Medicine | Shah B.A.,Indian Institute of Integrative Medicine
Organic Letters | Year: 2015

A metal-free oxidative coupling of styrenes and benzyl alcohols with arenes has been developed for the synthesis of biaryls. The reaction features a conspicuous benzylic C-C bond cleavage of styrenes and benzyl alcohols. The reaction with both substrates proceeds through a common aldehydic intermediate formed through oxidative C-C bond cleavage of alkene and oxidation of benzyl alcohols. The reaction proceeds efficiently over a broad range of substrates with excellent functional group tolerance. © 2015 American Chemical Society. Source

Kumar M.,Guru Nanak Dev University | Kumar N.,Guru Nanak Dev University | Bhalla V.,Guru Nanak Dev University | Sharma P.R.,Indian Institute of Integrative Medicine | Kaur T.,Indian Institute of Integrative Medicine
Organic Letters | Year: 2012

A highly selective fluorescent chemodosimeter based on rhodamine is synthesized which undergoes Cu 2+ driven hydrolysis in aqueous media to produce fluorescence turn-on changes with a detection limit up to the nanomolar range. © 2011 American Chemical Society. Source

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