The Indian Institute of Chemical Technology is a national-level research center located in Hyderabad, Telangana, India under the Council of Scientific and Industrial Research . IICT conducts research in basic and applied chemistry, biochemistry, bioinformatics, chemical engineering and provides science and technology inputs to the industrial and economic development of the country. IICT has filed one of the maximum CSIR patents. Wikipedia.
Patil N.T.,Indian Institute of Chemical Technology
Angewandte Chemie - International Edition | Year: 2011
A co-op: Recent examples on cooperative catalysis, involving metals (M) and N-heterocyclic carbenes (NHCs), delivered products with high enantioselectivity (see scheme). Such products are not possible to obtain by using either of the catalysts individually. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Rao R.N.,Indian Institute of Chemical Technology
Expert Review of Proteomics | Year: 2014
Dried blood spots (DBS), a micro blood sampling technique, has recently gained interest in drug discovery and development due to its inherent advantages over the conventional whole blood, plasma or serum sample collection. Since the regulatory authorities have agreed to the use of blood as an acceptable biological matrix for drug exposure measurements, its applications have been extended not only to therapeutic drug monitoring but also to toxicokinetic and pharmacokinetic studies. The pharmaceutical industry is keen to promote DBS as a prominent tool in bioanalytical applications due to the financial, ethical and organizational issues involved in clinical trials. This could be accomplished due to the latest advances in modern analytical technology, particularly liquid chromatography-mass spectrometry. The present review discusses some of the emerging liquid chromatography-mass spectrometry technologies in improving DBS analysis for its innovative applications in the development of new drugs. © 2014 Informa UK, Ltd.
Haldar A.K.,Indian Institute of Chemical Technology
PLoS pathogens | Year: 2010
The inability of sodium antimony gluconate (SAG)-unresponsive kala-azar patients to clear Leishmania donovani (LD) infection despite SAG therapy is partly due to an ill-defined immune-dysfunction. Since dendritic cells (DCs) typically initiate anti-leishmanial immunity, a role for DCs in aberrant LD clearance was investigated. Accordingly, regulation of SAG-induced activation of murine DCs following infection with LD isolates exhibiting two distinct phenotypes such as antimony-resistant (Sb(R)LD) and antimony-sensitive (Sb(S)LD) was compared in vitro. Unlike Sb(S)LD, infection of DCs with Sb(R)LD induced more IL-10 production and inhibited SAG-induced secretion of proinflammatory cytokines, up-regulation of co-stimulatory molecules and leishmanicidal effects. Sb(R)LD inhibited these effects of SAG by blocking activation of PI3K/AKT and NF-kappaB pathways. In contrast, Sb(S)LD failed to block activation of SAG (20 microg/ml)-induced PI3K/AKT pathway; which continued to stimulate NF-kappaB signaling, induce leishmanicidal effects and promote DC activation. Notably, prolonged incubation of DCs with Sb(S)LD also inhibited SAG (20 microg/ml)-induced activation of PI3K/AKT and NF-kappaB pathways and leishmanicidal effects, which was restored by increasing the dose of SAG to 40 microg/ml. In contrast, Sb(R)LD inhibited these SAG-induced events regardless of duration of DC exposure to Sb(R)LD or dose of SAG. Interestingly, the inhibitory effects of isogenic Sb(S)LD expressing ATP-binding cassette (ABC) transporter MRPA on SAG-induced leishmanicidal effects mimicked that of Sb(R)LD to some extent, although antimony resistance in clinical LD isolates is known to be multifactorial. Furthermore, NF-kappaB was found to transcriptionally regulate expression of murine gammaglutamylcysteine synthetase heavy-chain (mgammaGCS(hc)) gene, presumably an important regulator of antimony resistance. Importantly, Sb(R)LD but not Sb(S)LD blocked SAG-induced mgammaGCS expression in DCs by preventing NF-kappaB binding to the mgammaGCS(hc) promoter. Our findings demonstrate that Sb(R)LD but not Sb(S)LD prevents SAG-induced DC activation by suppressing a PI3K-dependent NF-kappaB pathway and provide the evidence for differential host-pathogen interaction mediated by Sb(R)LD and Sb(S)LD.
Suresh K.I.,Indian Institute of Chemical Technology
ACS Sustainable Chemistry and Engineering | Year: 2013
Global efforts to find renewable feedstocks for the chemical industry are aimed at replacing fossil reserves and a reduction in global warming by employing environmently friendly technologies (green chemistry approaches) for specialty chemical manufacturing. Cardanol, obtained as a byproduct of the cashew processing industry, is an important renewable resource and a unique phenolic compound carrying a 15-carbon side chain in meta position with varying degrees of unsaturation. In this work, the synthesis of new biobased polyols for rigid polyurethane (PU) foams through oxidation of side chain unsaturation is reported using the environmentally benign reagent hydrogen peroxide. Polyols with hydroxyl values in the range of 350-400 mg KOH/g were prepared through epoxidation followed by hydrolysis and characterized for structure using IR,1H-NMR, 13C NMR, and mass spectroscopic techniques. The foaming characteristics were studied, and the polyols were successfully used in making rigid polyurethane foams with good physical and mechanical properties. The foams were characterized for density, compressive strength, morphology, and viscoelastic properties. The properties are compared with that of foams prepared using standard petroleum-based polyols. © 2012 American Chemical Society.
Rani K.Y.,Indian Institute of Chemical Technology
Journal of Process Control | Year: 2012
A novel sensitivity compensating nonlinear control (SCNC) approach is proposed within generic model control (GMC) framework for processes exhibiting input sensitivity. The proposed approach consists of defining a new process, control law and set point such that the determined control action drives the original process to its desired set point. External reset feedback (ERF), used to compensate for input saturation, is extended to higher relative degree systems as extended ERF (EERF), and is incorporated in the context of SCNC approach. The proposed control algorithms are evaluated by application to an open-loop unstable CSTR control problem and a multi-product semi-batch polymerization reactor temperature control problem. The present study illustrates the versatility of the proposed SCGMC schemes compared to the basic GMC schemes in terms of output tracking and smoother input profiles. SCNC can be extended to other nonlinear model based controllers where the control law can be expressed analytically. © 2012 Elsevier Ltd. All rights reserved.