Index Medical College

Indore, India

Index Medical College

Indore, India
SEARCH FILTERS
Time filter
Source Type

Mishra P.K.,PGi | Sane M.R.,Government Medical College and Hospital | Saxena D.,Sukhsagar Medical College | Tomar J.S.,Index Medical College | Yadav A.,Index Medical College
Journal of Indian Academy of Forensic Medicine | Year: 2017

A 16 year old healthy young student suddenly fell down while playing football on school ground at about 4 pm and was suddenly rushed to hospital where he was declared 'brought in dead' by doctors. The case was brought to mortuary of Gandhi Medical College, Bhopal, and next day for medicolegal autopsy where diagnosis of Hypertrophic cardiomyopathy (HCM) was made. HCM is an inheritable autosomal dominant disease of heart muscle, characterized by a small left ventricular cavity and marked hypertrophy of myocardium with myofibril disarray. It has traditionally been considered a major cause of sudden death in physically active young person. The various aspects of the case are discussed in detail in this paper.


Kelotra S.,Mb Khalsa College | Jain M.,Devi Ahilya University | Kelotra A.,Devi Ahilya University | Jain I.,In silico Research Laboratory | And 3 more authors.
Asian Pacific Journal of Cancer Prevention | Year: 2014

Apoptosis is a general phenomenon of all multicellular organisms and caspases form a group of important proteins central to suicide of cells. Pathologies like cancer, Myocardial infarction, Stroke, Sepsis, Alzheimer's, Psoriasis, Parkinson and Huntington diseases are often associated with change in caspase 3 mediated apoptosis and therefore, caspases may serve as potential inhibitory targets for drug development. In the present study, two series of synthetic acetylated tetrapeptides containing aldehyde and fluromethyl keto groups respectively at the C terminus were proposed. All these compounds were evaluated for binding affinity against caspase 3 structure. In series 1 compound Ac-DEHD-CHO demonstrated appreciable and high binding affinity (Rerank Score: -138.899) against caspase 3. While in series 2 it was Ac-WEVD-FMK which showed higher binding affinity (Rerank Score: -139.317). Further these two compounds met ADMET properties and demonstrated to be non-toxic.


Aiman U.,Aligarh Muslim University | Najmi A.,Index Medical College | Khan R.A.,Aligarh Muslim University
Journal of Pharmacology and Pharmacotherapeutics | Year: 2014

Statins are one of the most commonly used drugs in the world based on their potential to prevent adverse cardiovascular events. These cholesterol-lowering drugs received a US Food and Drug Administration warning, in February 2012, regarding increased risk of incident diabetes and impaired glycemic control in patients who already have diabetes. The possible association of diabetes with statin therapy has started a wave of discussion in the medical community. A number of meta-analyses conducted in recent years have demonstrated that the association is real although causality has not been proved yet. Individual statins differ with respect to their diabetogenic property; women and elderly persons appear to be at increased risk. Various aspects of statin's adverse effect on glycemic control remain to be explored. As further research in this area continues, physicians might still take some precautions to make risk benefit ratio more favorable for the patients. © 2014 Journal of Pharmacology and Pharmacotherapeutics. All Rights Reserved.


Najmi A.,Index Medical College | Nasiruddin M.,JN Medical College | Khan R.A.,JN Medical College | Haque S.F.,JN Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2013

This study evaluated the effects of Nigella sativa (NS) on the systolic and diastolic blood pressure in patients of metabolic syndrome. We conducted an open lebeled study to test the efficacy of Nigella sativa as an antihypertensive in patients of metabolic syndrome. Patients were randomly divided into two groups (n=45 each). In group I (Std), patients were advised amlodipine 5 mg once a day, atenolol 50 mg once a day and atorvastatin 10 mg once a day for a period of eight weeks. In group II (NS group) patients were advised recommended doses of Nigella sativa (NS) in addition to abovementioned drugs for a period of eight weeks. Aspirin 150 mg was given in both groups. Each subject's BP was measured at the beginning of the study, then once every two weeks during the study. Measurements were always made at the same place and time after 15 min of rest. Venous blood was also collected from each subject before and after the study.NS significantly lowered SBP, DBP and LDL-c after 8 weeks. The NS group showed significant improvement with reference to SBP, DBP & LDL-cholesterol (P value < 0.05). Nigella sativa oil was found to be effective antihypertensive agent in patients of metabolic syndrome. The various mechanisms that may be responsible for antihypertensive effect of Nigella sativa are centrally acting antihypertensive activity, calcium channel blocking activity and its diuretic activity.


Najmi A.,Index Medical College | Nasiruddin M.,JN Medical College | Khan R.A.,JN Medical College | Haque S.F.,JN Medical College
Asian Journal of Pharmaceutical and Clinical Research | Year: 2012

Objective: This study evaluated the effects of Nigella sativa on the glycemic control in patients of metabolic syndrome with poor glycemic control (HbA1C > 7 %). Various parameters used to study about glycemic control were glycated hemoglobin (HbA1c), fasting blood glucose (FBG), postprandial blood glucose (PPBG) Material & Methods: Eighty Patients (80) were randomly divided into two groups (n=40 each) through random stratification by weight. In group I (Std), patients were advised metformin 500 mg twice a day & atorvastatin 10 mg once a day for a period of eight weeks. In group II (NS) patients were advised recommended doses of Nigella sativa (NS) in addition to abovementioned drugs. Aspirin 150 mg was given in both groups. Each subject's FBG, PPBG & HbA1c was measured at the beginning of the study, then once every two weeks during the study. Venous blood was also collected from each subject before and after the intervention for lipid profile. Results: Nigella sativa significantly lowered FBG, PPBG & HbA1c after 8 weeks. The NS group showed significant improvement with reference to FBG, PPBG, HbA1c, and LDL-cholesterol. Conclusions: Nigella sativa can be used as add on drug therapy in metabolic syndrome patients with poor glycemic control. Nigella sativa is safe and an effective remedy in patients of metabolic syndrome.


Patel T.,Government Medical College | Sharma H.S.,Index Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

otitis media are challenging disease in developing countries like India. Rural population is more commonly affected. The microbiology of otitis media is different in various regions that affect the use of proper antibiotics. This study was conducted on 128 patients of otitis media irrespective of age and sex. A complete physical and otological examination was performed. A questionnaire was prepared. A swab was prepared from ear discharge, if any, and sends for microbiological examination. Male female ratio was found to be 1.33: 1. Maximum numbers of cases were reported between 1-10 yrs. Commonest symptom was otalgia and otorrhea together. 5.88% cases showed both bacteria and fungi, 15.29 were negative for both bacteria and fungi. Pseudomonas aeruginosa was the commonly found bacteria and Candida albicans was the commonly occurring fungus.


Rathore S.,Index Medical College | Gupta A.,Chhatrapati Shahuji Maharaj Medical University | Batra H.S.,Armed Forces Medical College | Rathore R.,Index Medical College
Biomedical Research | Year: 2011

The aim of the present study is to assess the comparison of trace elements and serum ceru-loplasmin level in normal and pre-eclamptic pregnancies with their cord blood. Pregnancy is associated with increased demand of all the micronutrients like Iron, Copper, Zinc, Vit B12, Folic acid and Ascorbic acid. The pregnant women were admitted in maternity ward, Department of Obstetric and Gynecology, Command Hospital, Pune. The study group comprised of 61 pregnant women and their newborns. Venous blood (5 ml.) was collected from mother at the time of delivery and cord blood (10 ml.) was taken from maternal end of umbilical cord. Of 61 pregnant women, 14 were pre-eclamptic and 47 were normal pregnant women. In normal pregnancy, the copper & ceruloplasmin concentration were statistically significantly increased (p<0.01) in maternal blood as compared to cord blood. Serum iron and zinc concentration were observed significantly raised (p<0.01) in cord blood compared to maternal blood. Similar results were found in pre-eclamptic pregnancies. The significant difference (p<0.001) was observed in all biochemical parameters between maternal and cord blood pre-eclamptic pregnancies. On comparison of the normal and pre-eclamptic pregnancy, the serum iron significantly increased (p<0.01) in normal pregnancy than pre-eclamptic, but no statistically significant variations were observed in serum zinc, copper and ceruloplasmin concentration. Our study infers that iron is the most important micronutrient and it should be supplemented as a daily requirement in pregnant women. Ceruloplasmin can be used as a diagnostic measurement in pregnancy period.


Singh P.,Index Medical College | Harish D.,Government Medical College Hospital
Indian Journal of Forensic Medicine and Toxicology | Year: 2012

Despite the great advances in the treatment of Burns Cases, they remain one of the most distressing injuries for any patient and amongst the most challenging ones for the medical care giver. A prospective study was conducted to assess the causes, magnitude and profile of burns cases coming to Government Medical College & Hospital, Chandigarh. During the one year study period a total of 116 cases of burns were admitted, with the overall male to female ratio of 1: 1.42. Forty-six percent cases were seen in the 21-30 years age group, 48% were from the rural and urban background, each; 90% females were married. Maximum number of cases in females, 14 (21%), occurred in February, and of males 9 (19%) in November. Maximum cases in males (11; 23%) were in 31-40% TBSA, and in females (27; 23%) in >80% TBSA. Ninety-two percent cases suffered accidental burns, and the peak time of incidence was 6.00-9.00 pm, Kitchen (71%) was the most common place where these burn injuries were suffered especially among the female patients (81%).


Sutay S.S.,Index Medical College | Sheikh N.A.,Kamineni Institute of Medical science | Garg K.,Index Medical College | Gupta R.,Index Medical College
Medico-Legal Update | Year: 2016

Background: Stature of a person is one of the vital parts of identification. Assessment of height from different parts of the body by anthropometric study of skeleton is an area of interest to anatomist, anthropologist and forensic experts. Objective: An attempt was made to formulate a linear regression equation for the estimation of the stature of Medical Students of Madhya Pradesh and others from the lengths of their ulna. Study Design: Cross sectional study. Place of Study: Department of Forensic Medicine at R. D. Gardi Medical College, Ujjain, M.P. Methods: The present study was carried out to establish the regression equation and correlation co efficient between individual’s height and per-cutaneous ulnar length. It was conducted on the Medical students of second year, 147 subjects were selected irrespective of their caste, religion, dietary habits & socio-economic status. Observations: Regression equation for estimation of stature from Per-cutaneous ulnar length for both sex Y= 64.36+ 3.82 x PC ulnar Length, for individual male sex Y= 130.10 + 1.57 x PC ulnar Length and for Female sex Y= 75.94 + 3.21 x PC ulnar Length. The correlation coefficient between height & Percutaneous ulnar Length is highly significant. Conclusions: The present study revealed that Per-cutaneous ulnar length dimensions are strongly correlated with stature & can be used for predicting the stature in the Forensic Examination. © 2016, World Informations Syndicate. All rights reserved.


Sharma H.S.,Index Medical College | Mutalik M.M.,MIMER Medical College
International Journal of Pharma and Bio Sciences | Year: 2014

Student evaluation is done by various methods like a multiple choice question (MCQ), Essay questions, Structured essay question (SEQ), Modified essay question (MEQ), Objective structured clinical assessment (OSCE) in assessment of MBBS students in various universities worldwide. The present retrospective study compared the student performance in single-response MCQs and SEQs in the subject of otorhinolaryngology at the III MBBS examination at SSR Medical College, Mauritius. Performance of 639 students was analyzed over a period of 6 years, using SPSS-16 software. Scores in SEQs averaged at 47.63% (SD 11.90), while those in MCQs averaged at 55.24% (SD 17.90). MCQ scores were significantly higher than the SEQ scores when analyzed by two-way ANOVA. Pearson correlation between SEQ and MCQ scores was strongly significant indicating the performance to be independent of the type of questioning. Analysis of the scores of top-20% scorers (n=128) and bottom-20% scorers (n=128) did not show significant correlation.

Loading Index Medical College collaborators
Loading Index Medical College collaborators