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Vajzovic A.,University of Washington | Bura R.,University of Washington | Kohlmeier K.,Indevr, Inc. | Doty S.L.,University of Washington
Journal of Industrial Microbiology and Biotechnology | Year: 2012

A systematic study was conducted characterizing the effect of furfural, 5-hydroxymethylfurfural (5-HMF), and acetic acid concentration on the production of xylitol and ethanol by a novel endophytic yeast, Rhodotorula mucilaginosa strain PTD3. The influence of different inhibitor concentrations on the growth and fermentation abilities of PTD3 cultivated in synthetic nutrient media containing 30 g/l xylose or glucose were measured during liquid batch cultures. Concentrations of up to 5 g/l of furfural stimulated production of xylitol to 77 % of theoretical yield (10 % higher compared to the control) by PTD3. Xylitol yields produced by this yeast were not affected in the presence of 5-HMF at concentrations of up to 3 g/l. At higher concentrations of furfural and 5-HMF, xylitol and ethanol yields were negatively affected. The higher the concentration of acetic acid present in a media, the higher the ethanol yield approaching 99 % of theoretical yield (15 % higher compared to the control) was produced by the yeast. At all concentrations of acetic acid tested, xylitol yield was lowered. PTD3 was capable of metabolizing concentrations of 5, 15, and 5 g/l of furfural, 5-HMF, and acetic acid, respectively. This yeast would be a potent candidate for the bioconversion of lignocellulosic sugars to biochemicals given that in the presence of low concentrations of inhibitors, its xylitol and ethanol yields are stimulated, and it is capable of metabolizing pretreatment degradation products. © Society for Industrial Microbiology and Biotechnology 2012.

Morfa A.J.,National Renewable Energy Laboratory | Barnes T.M.,National Renewable Energy Laboratory | Ferguson A.J.,National Renewable Energy Laboratory | Levi D.H.,National Renewable Energy Laboratory | And 3 more authors.
Journal of Polymer Science, Part B: Polymer Physics | Year: 2011

We describe a comprehensive model for the optical properties of pristine films of poly-(3-hexylthiophene) (P3HT). The presented model is anisotropic with the optical axis normal to the substrate plane, which is consistent with previous x-ray diffraction studies that show preferential edge-on packing of the polymer chains on the substrate. Peak locations and spacings are defined using a Huang-Rhys vibronic progression consistent with known phonon energies. We demonstrate that the model fits variable-angle spectroscopic ellipsometry and normal-incidence transmission data well, and accurately predicts angle- and polarization-dependent transmission and reflection data. The spectral features of the optical constants used in the model are in excellent agreement with published spectroscopic data on P3HT. © 2010 Wiley Periodicals, Inc.

Indevr, Inc. | Entity website

Indevr, Inc. | Entity website

InDevR Receives ISO 13485:2003 Certification for Assays, Instrumentation and IVD Products Significant Milestone for BARDA-Funded FluChip-8G Product Development Boulder, CO OCTOBER 27, 2015 InDevR, Inc., an innovative life science company dedicated to improving biopharmaceutical and vaccine manufacturing, announced today that they received ISO 13485:2003 certification, an internationally recognized quality standard for medical devices ...

Indevr, Inc. | Entity website

Genotyping using target-specific microarrays can be more efficient and cost-effective than full genome sequencing for determining differences in the genetic makeup of pathogens. A few examples of our custom target microarrays for genotyping applications include: Influenza: InDevR is developing a new, multiplexed influenza diagnostic, FluChip-8G, with the goal of bringing a high information content influenza diagnostic closer to patients ...

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