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Grummt T.,Federal Environment Agency UBA | Kuckelkorn J.,RWTH Aachen | Bahlmann A.,Helmholtz Center for Environmental Research | Baumstark-Khan C.,German Aerospace Center | And 30 more authors.
Environmental Sciences Europe | Year: 2013

This article introduces 'Tox-Box', a joint research project designed to develop a holistic approach towards a harmonized testing strategy for exposure- and hazard-based risk management of anthropogenic trace substances in drinking water to secure a long-term drinking water supply. The main task of the Tox-Box consortium is to enhance the existing health-related indicator value concept (German: GOW-Konzept - Gesundheitlicher Orientierungswert) through development and prioritization of additional end point-related testing strategies for genotoxicity, neurotoxicity, germ cell damage, and endocrine effects. In this context, substance-specific modes of action will be identified and characterized. Toxicological data collected by the 12 Tox-Box subprojects will be evaluated and weighted to structure a hierarchical testing strategy for an improved risk assessment. A technical guidance document for exposure and hazard-based risk management of anthropogenic trace substances in drinking water will eventually be prepared. © 2013 Grummt et al.; licensee Springer. Source

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