Time filter

Source Type

Mexico City, Mexico

Villalobos-Comparan M.,National Autonomous University of Mexico | Villalobos-Comparan M.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran Incmnsz | Villamil-Ramirez H.,National Autonomous University of Mexico | Villamil-Ramirez H.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran Incmnsz | And 17 more authors.
PLoS ONE | Year: 2012

Background: Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity in European populations. We aimed to evaluate the contribution of these variants to obesity and related traits in Mexican children and adults. Methodology/Principal Findings: Rs6232 and rs6235 were genotyped in 2382 individuals, 1206 children and 1176 adults. Minor allele frequencies were 0.78% for rs6232 and 19.99% for rs6235. Rs6232 was significantly associated with childhood obesity and adult class III obesity (OR = 3.01 95%CI 1.64-5.53; P = 4×10-4 in the combined analysis). In addition, this SNP was significantly associated with lower fasting glucose levels (P = 0.01) and with increased insulin levels and HOMA-B (P = 0.05 and 0.01, respectively) only in non-obese children. In contrast, rs6235 showed no significant association with obesity or with glucose homeostasis parameters in any group. Conclusion/Significance: Although rs6232 is rare in the Mexican population, it should be considered as an important risk factor for extreme forms of obesity. © 2012 Villalobos-Comparán et al.

Cantu-Brito C.,INCMNSZ | Ruiz-Sandoval J.L.,Hospital Civil de Guadalajara Fray Antonio Alcalde | Arauz-Gongora A.,Autonomous University of Guadalajara | Villarreal-Careaga J.,Hospital General de Culiacan | And 3 more authors.
Revista Mexicana de Neurociencia | Year: 2010

Background: The importance of transient ischemic attack episodes (TIA) are related with the high risk of ischemic stroke in the following days or weeks. Indeed, around 20% of cerebral infarcts are preceded by a TIA. Objective: To determine the prevalence of carotid artery stenosis in Mexican patients with TIA. Patients and methods: By merging data bases of national registers on cerebrovascular diseases, patients were included in the current study if a carotid Doppler ultrasonography has been performed during their evaluation. Doppler findings were classified as 1) Normal, 2) Mild carotid atherosclerosis, and 3) Severe carotid stenosis >50%. Results: We studied 185 patients (99 men and 88 women), median age 70 years-old (IQR 60-77 years). Sixty patients (32.4%) had a normal Doppler, without atherosclerosis; 66 (35.7%) had non-stenotic plaques; and 59 (31.9%) had evidence of severe atherosclerosis with carotid stenosis >50%: 23 (12.4%) with 50-69% carotid stenosis, 23 (12.4%) stenosis of 70-99%, and 13 (7%) had atherothombotic occlusion. Conclusion: The current study allows estimating that in Mexico around 25% of patients with TIA have severe carotid stenosis. © Copyright Indice Mexicano de Revistas Biomédicas Latinoamericanas 1998 - 2011.

Leon-Mimila P.,National Autonomous University of Mexico | Leon-Mimila P.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran Incmnsz | Villamil-Ramirez H.,National Autonomous University of Mexico | Villamil-Ramirez H.,Instituto Nacional Of Ciencias Medicas Y Nutricion Salvador Zubiran Incmnsz | And 17 more authors.
PLoS ONE | Year: 2013

Background:Several studies have identified multiple obesity-associated loci mainly in European populations. However, their contribution to obesity in other ethnicities such as Mexicans is largely unknown. The aim of this study was to examine 26 obesity-associated single-nucleotide polymorphisms (SNP) in a sample of Mexican mestizos.Methods:9 SNPs in biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), and 17 SNPs in or near genes associated with obesity in first, second and third wave GWAS (INSIG2, FTO, MC4R, TMEM18, FAIM2/BCDIN3, BDNF, SH2B1, GNPDA2, NEGR1, KCTD15, SEC16B/RASAL2, NPC1, SFRF10/ETV5, MAF, PRL, MTCH2, and PTER) were genotyped in 1,156 unrelated Mexican-Mestizos including 683 cases (441 obese class I/II and 242 obese class III) and 473 normal-weight controls. In a second stage we selected 12 of the SNPs showing nominal associations with obesity, to seek associations with quantitative obesity-related traits in 3 cohorts including 1,218 Mexican Mestizo children, 945 Mexican Mestizo adults, and 543 Indigenous Mexican adults.Results:After adjusting for age, sex and admixture, significant associations with obesity were found for 6 genes in the case-control study (ADIPOQ, FTO, TMEM18, INSIG2, FAIM2/BCDIN3 and BDNF). In addition, SH2B1 was associated only with class I/II obesity and MC4R only with class III obesity. SNPs located at or near FAIM2/BCDIN3, TMEM18, INSIG2, GNPDA2 and SEC16B/RASAL2 were significantly associated with BMI and/or WC in the combined analysis of Mexican-mestizo children and adults, and FTO locus was significantly associated with increased BMI in Indigenous Mexican populations.Conclusions:Our findings replicate the association of 8 obesity-related SNPs with obesity risk in Mexican adults, and confirm the role of some of these SNPs in BMI in Mexican adults and children. © 2013 León-Mimila et al.

Pedroza-Torres A.,Instituto Nacional Of Cancerologia | Pedroza-Torres A.,National Polytechnic Institute of Mexico | Lopez-Urrutia E.,Instituto Nacional Of Cancerologia | Lopez-Urrutia E.,National Autonomous University of Mexico | And 11 more authors.
Molecules | Year: 2014

Cervical carcinoma (CC) is one of the most common cancers and a leading cause of mortality in women worldwide. Epidemiologic and experimental data have clearly demonstrated a causal role of high-risk Human Papillomavirus (HR-HPV) types in CC initiation and progression, affecting the cellular processes by targeting and inactivating p53 and pRB host proteins. HR-HPV E5, E6 and E7 oncoproteins have the ability to deregulate several cellular processes, mostly apoptosis, cell cycle control, migration, immune evasion, and induction of genetic instability, which promote the accumulation of mutations and aneuploidy. In this scenario, genomic profiles have shown that aberrant expression of cellular oncogenic and tumor suppressive miRNAs have an important role in CC carcinogenesis. It has been stated that HPV infection and E6/E7 expression are essential but not sufficient to lead to CC development; hence other genetic and epigenetic factors have to be involved in this complex disease. Recent evidence suggests an important level of interaction among E6/E7 viral proteins and cellular miRNA, and other noncoding RNAs. The aim of the current review is to analyze recent data that mainly describe the interaction between HR-HPV established infections and specific cellular miRNAs; moreover, to understand how those interactions could affect radio-Therapeutic response in tumor cells. © 2014 by the authors.

Espino-Urbina L.A.,Subespecialidad Cirugia de Colon y Recto INCMNSZ | Espinosa-De-Los-Monteros A.,Direccion de Cirugia INCMNSZ | Dominguez-Cherit J.,INCMNSZ | Chable-Montero F.,Fundacion Clinica Medica Sur | Vergara-Fernandez O.,Direccion de Cirugia INCMNSZ
Revista de Gastroenterologia de Mexico | Year: 2013

The literature reports an annual incidence of 5,900 cases of anal cancer in the developed countries. These involve three different anatomic zones: carcinoma of the anal canal, perianal carcinoma (formerly known as carcinoma of the anal margin, located at a distance of less than 5 cm from the anal margin), and carcinoma of the perianal skin (at a distance greater than 5 cm from the anal margin). Basal cell carcinoma of the perianal region is an uncommon tumor (0.27% of all diagnosed basal cell carcinomas) that in the majority of cases is treated by resection with disease-free margins. It must be differentiated from the basaloid and epidermoid variants of carcinoma, given that it has good outcome and its spread potential is practically null. © 2012 Asociación Mexicana de Gastroenterología.

Discover hidden collaborations