Århus, Denmark
Århus, Denmark

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Chen M.,iNANO | Wogensen L.,Faculty Secretariat | Forman A.,Aarhus University Hospital | Axelsen S.M.,Aarhus University Hospital
Journal of Biomedical Materials Research - Part B Applied Biomaterials | Year: 2017

Half of the female population over age 50 years will experience pelvic organ prolapse. We suggest a new approach based on tissue engineering principles to functionally reconstruct the anatomical structures of the pelvic floor. The aim of this study is to investigate the mechanical performance and effect on collagen and elastin production of a degradable mesh releasing basic fibroblast growth factor (bFGF). Implantation of biodegradable mesh with or without bFGF in their core has been conducted in 40 rats in an abdominal wall defect model. Samples were explanted after 4, 8, and 24 weeks, and tested for mechanical properties and the composition of connective tissue. The study showed an increase in mRNA expression for collagen-I (p=0.0060) and collagen-III (p=0.0086) in the 4 weeks group with bFGF. The difference was equalized at 8 and 24 weeks. No difference was found at any time for protein amount for collagen-I, collagen-III, and fibronectin. The amount of collagen decreased from 4 to 24 weeks but the fraction of collagen increased. The maximal load of the newly formed tissue showed no effect of bFGF at any time. Exclusively, histology showed a limited ingrowth of collagen fibers after 4 weeks with bFGF but signs of elastin fibers were seen at 24 weeks. The investigation showed that a biodegradable mesh promotes tissue formation with a promising strength. The mesh with bFGF did not represent any advantage on either long or short term in comparison to the mesh without bFGF. © 2017 Wiley Periodicals, Inc.


Larsen E.K.U.,University of Aarhus | Nielsen T.,INANO | Wittenborn T.,INANO | Rydtoft L.M.,Aarhus University Hospital | And 8 more authors.
Nanoscale | Year: 2012

Iron oxide nanoparticles have found widespread applications in different areas including cell separation, drug delivery and as contrast agents. Due to water insolubility and stability issues, nanoparticles utilized for biological applications require coatings such as the commonly employed polyethylene glycol (PEG). Despite its frequent use, the influence of PEG coatings on the physicochemical and biological properties of iron nanoparticles has hitherto not been studied in detail. To address this, we studied the effect of 333-20000 Da PEG coatings that resulted in larger hydrodynamic size, lower surface charge, longer circulation half-life, and lower uptake in macrophage cells when the particles were coated with high molecular weight (M w) PEG molecules. By use of magnetic resonance imaging, we show coating-dependent in vivo uptake in murine tumors with an optimal coating M w of 10000 Da. © 2012 The Royal Society of Chemistry.


Krogsgaard M.,INANO | Nue V.,INANO | Birkedal H.,INANO
Chemistry - A European Journal | Year: 2016

Improved understanding of the underwater attachment strategy of the blue mussels and other marine organisms has inspired researchers to find new routes to advanced materials. Mussels use polyphenols, such as the catechol-containing amino acid 3,4-dihydroxyphenylalanine (DOPA), to attach to surfaces. Catechols and their analogues can undergo both oxidative covalent cross-linking under alkaline conditions and take part in coordination chemistry. The former has resulted in the widespread use of polydopamine and related materials. The latter is emerging as a tool to make self-healing materials due to the reversible nature of coordination bonds. We review how mussel-inspired materials have been made with a focus on the less developed use of metal coordination and illustrate how this chemistry can be widely to make self-healing materials. Inspired by nature: The ability of blue mussels and other marine creatures to attach to surfaces underwater and to make advanced materials has gained increasing awareness and interest amongst chemists. The combination of catechols and coordination chemistry to yield self-healing materials is the most recent sprout on this growing tree and is the focus of this Minireview. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


Krogsgaard M.,INANO | Andersen A.,INANO | Birkedal H.,INANO
Chemical Communications | Year: 2014

An inexpensive one-pot route to self-healing hydrogels with pH-tunable modulus is presented. Hydrogels were formed by reacting tannic acid, trivalent metal ions and polyallylamine. Below pH 8 the hydrogels were supramolecular while above, covalent cross-linking strengthened the hydrogels. From concentrated mixtures, threads were spun, acting as water sensitive mechanical locks. This journal is © the Partner Organisations 2014.


PubMed | iNANO
Type: Journal Article | Journal: Chemistry (Weinheim an der Bergstrasse, Germany) | Year: 2016

Improved understanding of the underwater attachment strategy of the blue mussels and other marine organisms has inspired researchers to find new routes to advanced materials. Mussels use polyphenols, such as the catechol-containing amino acid 3,4-dihydroxyphenylalanine (DOPA), to attach to surfaces. Catechols and their analogues can undergo both oxidative covalent cross-linking under alkaline conditions and take part in coordination chemistry. The former has resulted in the widespread use of polydopamine and related materials. The latter is emerging as a tool to make self-healing materials due to the reversible nature of coordination bonds. We review how mussel-inspired materials have been made with a focus on the less developed use of metal coordination and illustrate how this chemistry can be widely to make self-healing materials.

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