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Dain L.,Carmel Medical Center | Ojha K.,St. Georges Hospital | Ojha K.,London Bridge Gynecology Fertility and Genetic Center | Bider D.,Sheba Medical Center | And 4 more authors.
Fertility and Sterility | Year: 2014

Design: Retrospective cohort analysis of ovum donation cycles conducted from 2005 to 2012.Objective: To evaluate the effect of local endometrial injury (LEI) on clinical outcomes in ovum donation recipients.Setting: Two private IVF centers.Patient(s): Total 737 ovum donation cycles.Intervention(s): LEI by endometrial "scratch" with the use of a Pipelle catheter.Main Outcome Measure(s): Clinical pregnancy and live birth rates.Result(s): No statistically significant differences were found in clinical pregnancy rates and live birth rates in cycles subjected to LEI compared with those without. Combination of LEI with fibroid uterus resulted with significantly higher clinical pregnancy rates compared with LEI in normal uterine anatomy.Conclusion(s): This is the first study done in ovum recipients who underwent LEI by a "scratch" procedure after failed implantation. Unlike most previous reports, which found improved pregnancy rates with the use of "scratch effect" or "minor endometrial injury" after repeated implantation failures in standard IVF with own eggs, we did not find any changes in implantation rates in a population of egg recipients following this procedure. In view of a possible positive effect of LEI in cycles with a previous four or more failures, prospective randomized controlled studies are warranted to better define the target population who may benefit from this intervention. © 2014 American Society for Reproductive Medicine. Source


Dain L.,Carmel Medical Center | Bider D.,Sheba Medical Center | Levron J.,Sheba Medical Center | Zinchenko V.,In Vitro Fertilization Center | And 2 more authors.
Fertility and Sterility | Year: 2013

Objective To evaluate the combined effect of endometrial thickness and anatomic uterine factors on clinical outcome in oocyte donation recipients. Design Retrospective analysis of oocyte donation cycles conducted between 2005 and 2010. Setting Two private IVF centers. Patient(s) A total of 737 donor oocyte cycles. Intervention(s) None. Main Outcome Measure(s) Clinical pregnancy and live birth rates. Result(s) No statistically significant difference was found in clinical pregnancy rates and live birth rates in cycles with endometrial thickness <6 mm compared with those with endometrial thickness >10 mm. However, a relatively high rate of live births was found within a medium range of endometrial thickness (8.2-10 mm). All intrauterine adhesion cases occurred in cycles with thinner endometrium. Conclusion(s) No statistically significant difference was found in clinical pregnancy rates and live birth rates in cycles with endometrial thickness <6 mm compared with those with thickness >6 mm. A relatively high rate of live births was found within a medium range of endometrial thickness (9.1-10 mm). © 2013 by American Society for Reproductive Medicine. Source


Yapan C.C.,Reproductive Genetics Laboratory | Beyazyurek C.,Reproductive Genetics Laboratory | Ekmekci C.G.,Reproductive Genetics Laboratory | Kahraman S.,In Vitro Fertilization Center
Balkan Journal of Medical Genetics | Year: 2014

Carriers of inversions involving euchromatic regions are at risk of having unbalanced offspring due to meiotic crossover. In carriers, recombination can occur during gametogenesis and cause genetically unbalanced sperm and subsequently unbalanced embryos. Here we present segregation analysis results of an infertile male with 46,XY,inv(2) (q21.2q37.3) using fluorescent in situ hybridization (FISH) on sperm cells. This is the largest paracentric inversion (PAI) reported so far in a meiotic segregation analysis study. Sperm FISH revealed 28.0% recombinant spermatozoa rate for chromosome 2, which was the highest rate in PAI carriers in the literature. Our results indicate a clear correlation between the size of the inverted segment and the frequency of the recombinant spermatozoa. The results of the FISH analysis with the information of unbalanced spermatozoa rate can provide accurate counseling on the genetic risk of infertility. Source


Hussein A.,In Vitro Fertilization Center | AlGadaa A.,Qassim University | ElFaras M.,In Vitro Fertilization Center | ElFiky M.,In Vitro Fertilization Center
UroToday International Journal | Year: 2011

INTRODUCTION: Smoking is considered a risk factor for male infertility, but studies have not shown a conclusive reduction in fertility associated with paternal smoking. The aim of the present study was to investigate the effects of smoking cigarette or shisha tobacco on semen parameters in men with subfertility. METHODS: This was a prospective study of 100 patients with subfertility. There were 50 smokers with mean (SD) age of 37.1 (8.3) years and 50 nonsmokers with a mean age of 39.5 (9.0) years. The outcome measures were sperm abnormal forms (%), sperm count (M/mL), semen volume (mL), sperm motility (%), duration of infertility, and type, amount, and duration of smoking. Group differences (smoker vs nonsmoker and cigarette vs shisha) in semen volume and sperm parameters were analyzed with t tests. Pearson correlations were calculated to determine the association between smoking index and smoking duration and the semen parameters. RESULTS: When compared with nonsmokers, the smokers had a significantly higher mean percentage of abnormal sperm forms (92.3% vs 89.4%) (P <.01), a significantly lower mean sperm count (20.6 M/mL vs 44.9 M/mL), a significantly lower mean semen volume (2.01 mL vs 2.52 mL), and a significantly lower mean percentage of sperm motility (25.7 vs 37.9) (all with P <.01). There were no statistically significant differences in semen parameters between men smoking cigarettes or shisha. There were statistically significant negative correlations between smoking index and the percentage of sperm motility (r = -0.38; P =.006) and between smoking duration and the percentage of sperm motility (r = -0.32; P =.026). There was also a marginally significant positive correlation between smoking index and the percentage of abnormal sperm forms (r =0.28; P =.046). Correlations with other semen parameters were not significant. CONCLUSION: Results showed significant deleterious effects of tobacco smoking on semen parameters. The correlation analysis placed special emphasis on the negative impact of smoking on sperm motility. Evidence from this and other studies seems sufficient to recommend that male smokers with subfertility should stop smoking to prevent detrimental effects on semen quality. © 2011 UroToday International Journal/Vol 4/Iss 1/February. Source


Kalem M.N.,Ankara University | Kalem Z.,In Vitro Fertilization Center | Yuce E.,Ankara University | Eser A.,Ankara University | Duvan Z.C.I.,Ankara University
Turk Jinekoloji ve Obstetrik Dernegi Dergisi | Year: 2015

In the last 20 to 30 years, early diagnosis of pregnancy has markedly decreased ectopic pregnancy-related maternal mortality, and the necessity for surgical treatment. With modern approaches in the treatment of ectopic pregnancy, surgical therapy has been replaced by medical therapy and medical treatment by spontaneous follow-up in appropriate cases. However, this current trend has led to some problems, including the maximization of ultrasonographic interpretations, misunderstandings in serial human koryonik gonadotropin hormon measurements, and complications due to inappropriate methotrexate use. The aim of the present study was to review the literature relating to the diagnosis and follow-up of early pregnancies, to underline some of the important considerations, and to help avoid possible iatrogenic errors. © 2015, Turkish Society of Obstetrics and Gynecology. All rights reserved. Source

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