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Jin C.H.,Korea Atomic Energy Research Institute | Yang H.S.,Imsil Research Institute of Cheese Science | Choi D.S.,Korea Atomic Energy Research Institute | Byun M.W.,Woosong University | And 2 more authors.
Food Science and Biotechnology | Year: 2013

Rosmarinic acid (RA), a food-derived polyphenolic compound, has been reported to possess anti-oxidant, antiallergic, and anti-inflammatory activities. In this study, we investigated whether RA has cytoprotective activity in SIN-1 induced HepG2 cells and how to achieve it. The results show that RA attenuates SIN-1 induced cytotoxicity in HepG2 cells. RA significantly reduces the intracellular reactive oxygen species (ROS) generated from SIN-1 and induced heme oxygenase-1 (HO-1) expression. RA-induced HO-1 expression was attenuated by a pretreatment with specific inhibitors for JNK, ERK, and phosphoinositide 3-kinase (PI3K). The addition of N-acetyl-cysteine (NAC) also reduced HO-1 induction in RA-induced cells. Furthermore, RA induced the translocation of NF-E2-related factor 2 (Nrf2). Taken together, we conclude that RA attenuates cytotoxicity in SIN-1-induced HepG2 cells by direct radical scavenging activity and HO-1 induction through a ROS/PI3K/MAPKs/Nrf2 pathway. © 2013 The Korean Society of Food Science and Technology and Springer Science+Business Media Dordrecht. Source


Huh C.K.,Imsil Research Institute of Cheese Science | Hwang T.Y.,Sunchon National University
Preventive Nutrition and Food Science | Year: 2016

This study was performed to investigate the antifungal substances and the antifungal activity against fungi of lactic acid bacteria (LAB) isolated from kimchi. LAB from kimchi in Imsil showed antifungal activity against Penicillium brevicompactum strain FI02. LAB LI031 was identified as Lactobacillus sakei subsp. Antifungal substances contained in L. sakei subsp. ALI033 culture media were unstable at high pH levels. Both, the control and proteinase K and protease treated samples showed clear zones, suggesting that the antifungal substances produced by ALI033 were non-protein substances unaffected by protesases. Both, the control and catalase showed clear zones, suggesting that the antifungal metabolite was not H2O2. The molecular weights of the antifungal substances were ≤3,000 Da. The organic acid content of crude antifungal substances produced by L. sakei subsp. ALI033 showed high concentrations of lactic acid (502.47 mg/100 g). Therefore, these results suggest that antifungal substance produced by L. sakei subsp. ALI033 is most likely due to its ability in producing organic acid. © Copyright 2016 by The Korean Society of Food Science and Nutrition. All rights Reserved. Source


Huh C.K.,Imsil Research Institute of Cheese Science | Shim K.H.,Sunchon National University | Kim Y.D.,Sunchon National University
Korean Journal of Food Science and Technology | Year: 2016

This study invesigated the physicochemical properties of rice flours from conventional and high-yielding rice varieties in order to enhance usability processing of high-yielding rice varieties. Moisture content was not remarkably different among rice flours by cultivar. The highest content of total free sugars was detected in Hopum rice. Apparent amylose content of Anda was higher than that of other rice varieties. The total amount of amino acids was highest in Anda rice among the rice cultivars. Contents of vitamin B1 in Hanarum were highest among the rice cultivars. Initial pasting temperature was lowest in Anda rice (60.10°C). Hanarum rice showed the lowest setback values among the rice flours. Therefore, Anda and Hanarum rice cultivars were suggesting the possibility of a processed rice food source. © The Korean Society of Food Science and Technology. Source


Lee S.J.,Raspberry | Lee M.J.,Raspberry | Ko Y.J.,Raspberry | Choi H.R.,Raspberry | And 7 more authors.
Korean Journal of Food Science and Technology | Year: 2013

We investigated the effects of water extracts of unripe black raspberry (UBR) and red ginseng (RG) on cholesterol synthesis, 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase activity, and expression of low-density lipoprotein (LDL) or high-density lipoprotein (HDL)-related genes in HepG2 and Caco-2 (human hepatoma and intestinal cell lines, respectively). Our results showed that cholesterol synthesis and HMG-CoA reductase activity in HepG2 cells were inhibited by UBR and RG. Further, co-treatment with UBR and RG had a greater effect than did treatment with either UBR or RG. In Caco-2 cells, treatment with UBR and RG increased the expression of LDL-regulated genes, such as LDL receptor and SREBP-2, and also upregulated the level of HDL-associated ABCA1. Moreover, co-treatment with UBR and RG appeared to be more effective than treatment with either UBR or RG. Taken together, our results indicate that UBR and RG regulate the level of HDL-associated ABCA1 via signaling pathway, thereby preventing cholesterol synthesis. © The Korean Society of Food Science and Technology. Source


Lee M.J.,Raspberry | Lee S.J.,Raspberry | Choi H.R.,Raspberry | Lee J.-H.,Raspberry | And 7 more authors.
Journal of the Korean Society of Food Science and Nutrition | Year: 2014

We examined the effects of unripe black raspberry (UBR) and red ginseng (RG) extracts on cholesterol improvement in C57BL/6J mice fed a HCD (high cholesterol diet) for 12 weeks. Hepatic total lipid and total cholesterol contents were significantly induced in hyperlipidemic mice. However, supplementation with UBR, RG and simvastatin effectively reduced these lipid profiles. Further, UBR and co-treatment with UBR and RG increased expression of LDL receptor, SREBP2, and SR-B1 mRNA compared with HCD. The ApoB/ApoA1 ratio was reduced by co-treatment with UBR and RG compared to treatment with UBR. In addition, histopathologic evaluation showed that co-treatment with UBR and RG suppressed lipid accumulation as well as FAS and leptin expression in plasma. These results indicate that co-treatment with UBR and RG may be useful for the prevention of hypercholesterolemia. © 2014, Korean Society of Food Science and Nutrition. All rights reserved. Source

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