IMS BHU

India
India
SEARCH FILTERS
Time filter
Source Type

Gaur P.K.,Jodhpur National University | Purohit S.,IMS BHU | Kumar Y.,Its Paramedical Pharmacy College | Mishra S.,Jamia Hamdard University | Bhandari A.,Jodhpur National University
Pharmaceutical Development and Technology | Year: 2014

Context: Transdermal formulations contain permeation enhancer which causes skin damage. Ceramide 2 is natural lipid found in stratum corneum (SC). Objective: Drug-loaded nanovesicles of ceramide-2, cholesterol, palmitic acid, cholesteryl sulfate were formulated and analyzed for physical and biological properties. Diclofenac was used as a model drug. Materials and method: The vesicles were prepared using the film hydration method and characterized for physical parameters, in vitro drug release, accelerated stability studies and formulated into gel. Respective gels were compared with a commercial formulation (CEG) and plain carbopol gel (CG) containing drug for ex vivo, in vivo drug permeation and antiinflammatory activity. Results: The vesicles were stable with optimum physical parameters. DCG-1 showed 92.89% in vitro drug release. Ceramide vesicles showed drug release between 18 and 25 mg/cm2 whereas CG and CEG released 0.33 and 1.35 mg/cm2 drug, respectively. DCG-1 and CEG showed corresponding Cmax at 6 and 4 h, respectively. DCG-1 showed six times AUC than CEG. DCG-1 inhibited edema by 86.37% by 4th hour of application. Discussion: The presence of ceramide 2 specifically promotes the drug permeation through SC and dermis and also contribute towards stability and non-irritancy. Conclusion: The composition of the nanovesicle played an important role in physical properties and drug permeation. © 2014 Informa Healthcare USA, Inc.


Tripathi J.N.,P.A. College | Dwivedi K.N.,I.M.S. B.H.U
Biomedical and Pharmacology Journal | Year: 2011

Diabetes now a days is a global problem. Diabetes mellitus is one of the most prevalant diseases of adults. It will affect a person regardless of weight, age, or race, ,especially if diabetes runs in the family. Medicinal plants used to treat hypoglycemic and hyperglycemic conditions are of considerable interest to ethno-botanical community as they are recognized to contain valuable medicinal properties in different parts of the plant. The active principles of many plant species with desired properties are isolated to cure ailments such as diabetes type-1 and type-2, respectively.


Kumar B.,SGPGIMS | Bhatnagar A.,SGPGIMS | Upadhyaya V.D.,SGPGIMS | Gangopadhyay A.N.,IMS BHU
Journal of Clinical and Diagnostic Research | Year: 2017

Cystic lymphangioma of small bowel mesentery is rare with clinical features ranging from an asymptomatic abdominal lump to acute intestinal obstruction. We discuss two cases of lymphangioma of small bowel mesentery who presented to us as acute intestinal obstruction. In the first case exploratory laparotomy revealed a large multicystic lesion arising from small bowel mesentery just distal to the duodenojejunal junction having multiple small cysts filled with milky white fluid. The involved region of the bowel was excised. The second case had a large multicystic lesion involving the mesentery of proximal jejunum, dudenojejunal junction, encasing the entire superior mesenteric vessels. For this patient, debulking was done. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.


Tripathi G.,Arise 43 | Yadav M.K.,IMS BHU | Padhyay P.,IMS BHU | Mishra S.,IMS BHU
International Journal of PharmTech Research | Year: 2015

Dyeing is a complex, specialized science. Nearly all dye stuffs are now producing from synthetic compounds. This means that costs have been greatly reduced and certain application and wear characteristics have been greatly enhanced. But many practitioners of the craft of natural dyeing (i.e. using naturally occurring sources of dye) maintain that natural dyes have a far superior aesthetic quality which is much more pleasing to the eye. On the other hand, many commercial practitioners feel the natural dyes are non-viable on grounds of both quality and economics. In the west, natural dyeing is now practiced only as a handcraft, synthetic dye being used in all commercial applications. Some craft, weavers and knitters use natural dye as a particular feature of their work. © 2015, Sphinx Knowledge House. All rights reserved.


Jain D.,Banaras Hindu University | Kumar V.,IMS BHU | Kar D.P.,IMS BHU | Prasad S.R.,IMS BHU
Indian Heart Journal | Year: 2013

A 35-year-old man presented with dilated cardiomyopathy, an unusual association with tuberous sclerosis. Clinical history and examination were consistent with tuberous sclerosis including major features of tuberous sclerosis complex (TSC) like facial angiofibroma, shagreen patch, subependymal nodules, and angiomyolipoma of kidney. The clinical manifestations, pathogenesis and evaluation of tuberous sclerosis are discussed. © 2012, Cardiological Society of India. All rights reserved.


Gaur P.K.,Its Paramedical Pharmacy College | Gaur P.K.,Jodhpur National University | Purohit S.,IMS BHU | Kumar Y.,Its Paramedical Pharmacy College | Bhandari A.,Jodhpur National University
Artificial Cells, Nanomedicine and Biotechnology | Year: 2014

Lipid vesicles are an important drug carrier which can serve for controlled delivery of drugs; however, these vesicles are quite unstable at ambient temperature and require stringent storage condition. Present work was done to develop a stable vesicular system for drug delivery. Vesicles of ceramide-2, cholesterol, cholesterol sulfate, and palmitic acid were prepared and compared with phosphatidylcholine vesicles for physicochemical parameters and accelerated stability. Diclofenac sodium was used as a model drug. Based on physicochemical parameter and in vitro release PCV-3 and CV-3 were selected for further studies in three different accelerated stability conditions. PCV-3 showed moderate changes at 4°C but was severely affected at 25°C and 40°C. CV-3 showed stable characteristics at 4°C and 25°C whereas at 40°C, CV-3 showed signs of slight modification owing to moisture absorption. Based on the study, CV-3 containing highest content of palmitic acid was found to be most stable. © 2014 Informa Healthcare USA, Inc.


Gaur P.K.,Its Paramedical Pharmacy College | Gaur P.K.,Jodhpur National University | Purohit S.,IMS BHU | Mishra S.,Jamia Hamdard University
Journal of Biomaterials Science, Polymer Edition | Year: 2013

Context: Aceclofenac is an important NSAID; however, it causes GI disturbances whereas employing transdermal route would require permeation enhancer for systemic application, thereby causing skin damage. Ceramide 2 is a natural lipid having an important role in the maintenance of skin. Objective: Aceclofenac-loaded nanovesicles of ceramide-2, cholesterol, palmitic acid, and cholesteryl sulfate were formulated and analyzed for physical and biological properties. Materials and method: Film hydration method was used to prepare the vesicles and physical parameters, in vitro drug release and stability were evaluated. Then, they were formulated into gel and evaluated against a commercial formulation (CF) and gel-containing plain drug (CPG) for ex vivo, in vivo drug permeation, and anti-inflammatory activity. Results: The developed formulations showed best physical profile and ACV-1 gave 92.89% drug release in in vitro studies. Ex vivo studies showed drug permeation between 15.32-31.12 μg/cm2, whereas CPG and CF released 0.47 and 2.81 μg/cm 2, respectively. ACVG-1 and CF showed Cmax of 8.1 and 1.2 μg/ml at 8 and 4 h, respectively. ACVG-1 showed 11.6 times AUC than CF. ACVG-1 inhibited edema by 44% in first hour itself. Discussion: Ceramide 2 and palmitic acid played an important role in the formulation and promotes the drug permeation through stratum corneum and dermis. Ceramide content of the formulation also contributes towards stability and skin protection. Conclusion: The composition of the vesicle formulation performs an important role in physical properties and drug permeation, thereby producing an optimum formulation. © 2013 © 2013 Taylor & Francis.


Kansal S.,IMS BHU | Kumar A.,IMS BHU
Indian Journal of Public Health Research and Development | Year: 2014

Research question: What is the extent of knowledge about tuberculosis and different components of RNTCP among people residing in an urban area of Varanasi? Objectives: 1. To assess the knowledge of residents of study area regarding tuberculosis and different component of RNTCP. 2. To identify socio-demographic correlates influencing the knowledge of population about tuberculosis and RNTCP. Study Design: Community based cross sectional study. Setting: The Study was carried out in an urban area of Varanasi district. Results: A total of 667 subjects were interviewed. It was found that about one third of the study subjects were not aware about the correct cause of tuberculosis as germs. The study reveals that 85.8% study subjects had knowledge of DOTS centre and 52.6% knew about DOTS provider. Duration of treatment of tuberculosis ranged from 6 to 9 months was known to 47.0% subjects while 32.0% had no idea about it. Majority (64%) mentioned/ reported that stigma is the main reason for delay in seeking treatment. Still stigma associated with TB is widely prevalent. Approximately 88.0% of them knew that tuberculosis is curable. Conclusion: Overall knowledge of population of urban area was found to be fairly good. Community based efforts are also required to identify the DOTS provider as major change agent in the demand generation as well as service provision. As the programme is based on passive surveillance, IEC strategies should be tailor made & suited to all the needs of a sub population.


Gaur P.K.,Jodhpur National University | Gaur P.K.,Its Paramedical Pharmacy College | Purohit S.,IMS BHU | Kumar Y.,Its Paramedical Pharmacy College | And 2 more authors.
Drug Development and Industrial Pharmacy | Year: 2014

Context: The vesicles based on skin lipid have a drug localization effect and its main lipid, ceramide provides protective and regenerative effects while oleic acid (OA) is a penetration enhancer, however, it causes slight irritation, so we have formulated formulation incorporating both of these to develop a transdermal formulation for better permeation. Objective: Present study investigated the preparation and characterization of physicochemical properties and permeation of nanovesicles of ceramide-2 containing OA and palmitic acid (PA) respectively and a commercial gel. Materials and methods: The vesicles were made using ceramide 2, cholesterol (Chol), cholesteryl sulfate (CS) and OA or PA, respectively, using film hydration method. The vesicles were characterized for physicochemical properties, ex vivo permeation using human skin and pharmacokinetic parameters and anti-inflammatory activity in rats. Results: The vesicles showed size at 102-125nm while PDI was 0.11-0.13 and negative zeta potential. OV-3 showed highest entrapment efficiency. The drug fluxes were 92.02 and 8.920μg/cm2/h, respectively, for OV-3 and PV-1. The Cmax were 7.91 and 4.01μg/ml at 4 and 6h for OV-3 (2.5mg) and PV-1 (10mg), respectively. OV-3 and PV-1 showed 98.8% and 77.36% edema inhibition, respectively, at 3h. Discussion: Both formulations showed similar physical parameters and different permeation since OA get incorporated in vesicles and increases its permeability and ceramide makes sure that vesicles can rapidly traverse the stratum corneum. Conclusion: OV-3 containing 3% OA showed optimum physical parameters and good permeation with maximum anti-inflammatory activity. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.


Kansal S.,IMS BHU | Kumar A.,IMS BHU
Indian Journal of Public Health Research and Development | Year: 2011

Research Question: What is the extent of knowledge about tuberculosis and different components of RNTCP among people residing in an urban area of Varanasi? Objectives: 1. To assess the knowledge of residents of study area regarding tuberculosis and different component of RNTCP. 2. To identify socio-demographic correlates influencing the knowledge of population about tuberculosis and RNTCP. Study Design: Community based cross sectional study. Setting The Study was carried out in an urban area of Varanasi district. Results: A total of 667 subjects were interviewed. It was found that about one third of the study subjects were not aware about the correct cause of tuberculosis as germs. The study reveals that 85.8% study subjects had knowledge of DOTS centre and 52.6% knew about DOTS provider. Duration of treatment of tuberculosis ranged from 6 to 9 months was known to 47.0% subjects while 32.0% had no idea about it. Majority (64%) mentioned/ reported that stigma is the main reason for delay in seeking treatment. Still stigma associated with TB is widely prevalent. Approximately 88.0% of them knew that tuberculosis is curable. Conclusion: Overall knowledge of population of urban area was found to be fairly good. Community based efforts are also required to identify the DOTS provider as major change agent in the demand generation as well as service provision. As the programme is based on passive surveillance, IEC strategies should be tailor made & suited to all the needs of a sub population.

Loading IMS BHU collaborators
Loading IMS BHU collaborators