News Article | May 5, 2017
EDINBURGH, Scotland & SAN DIEGO--(BUSINESS WIRE)--DYSIS Medical, Ltd. announced today that the prospective IMPROVE-COLPO clinical study, the first large scale study of community colposcopy practices, has enrolled more than 7,000 patients in 44 community clinics in the United States and reached statistical significance in its primary endpoint. Interim data from the study will be presented at the 2017 ACOG (American College of Obstetricians and Gynecologists) Annual Clinical and Scientific Meeting being held May 6-9 in San Diego, CA. The study’s endpoint - to detect increased high grade cervical dysplasia with the use of the DYSIS colposcope compared to matched provider data using a standard colposcope - demonstrated clinically and statistically significant increases in detection rates for high-grade lesions overall and CIN3+ (the immediate pre-cursor to invasive cancer) over standard colposcopy. This was done with fewer biopsies that yielded negative results. DYSIS Medical’s CEO Alastair Atkinson commented, "The IMPROVE-COLPO study demonstrates the outstanding clinical outcomes generated by the DYSIS cervical map and will no doubt help clinicians better stratify risk and follow patients appropriately.” The unique study design was employed to establish the baseline of how standard colposcopy was practiced by 160 physicians in 44 clinics using current binocular colposcopes. This retrospective chart review demonstrated the variability in compliance to colposcopy treatment guidelines and very low disease detection. The prospective arm of the study used the DYSIS colposcope – which standardizes the examination and measures the degree of acetowhitening in cervical tissue – creating a color-coded map to highlight the most acetowhite areas. The patient exams were matched by provider – one retrospective exam with their standard colposcope to one prospective exam with DYSIS. In a sub-group population of 3,000 women with borderline Pap smears/high-risk HPV (the most difficult cases to assess visually because lesions are typically small), the DYSIS colposcope demonstrated a 51% increased detection rate for high-grade lesions overall. Moreover, detection of CIN3+ increased 73% over standard colposcopy. Both are statistically and clinically significant. This was done with fewer biopsies that yielded negative results. The DYSISmap-directed biopsies were 55.8% more likely to yield high grade disease than biopsies identified with a standard colposcope. DYSIS based in Edinburgh, Scotland and Tampa, Florida, is committed to saving lives through the early detection and diagnosis of disease using biophotonic innovations. The Company aims to be the global leader in automated optical molecular imaging technologies for medical diagnostic and screening applications. For more information, please visit: www.dysismedical.com or call 844-DYSISMED.
Kernisan L.P.,University of California at San Francisco |
Sudore R.L.,University of California at San Francisco |
Sudore R.L.,Improve-in |
Journal of Medical Internet Research | Year: 2010
Background: The Internet is widely used for health information, yet little is known about the online activity of family caregivers of elders, a rapidly growing group. In order to better understand the online information-seeking activity of "e-caregivers" and other visitors at a caregiving website, we undertook a qualitative analysis of survey data from a website marketed as a comprehensive resource for adults caring for aging parents. Objective: The objectives were to better understand what types of information ar sought by those visiting a website focused on elder-care issues and to identify overarching themes that might inform future development of Internet resources related to caregiving and aging. Methods: From March 2008 to March 2009, a 5-question pop-up survey was offered 9662 times and completed 2161 times. For 1838 respondents, included was a free text answer to the question "What were you looking for?" and 1467 offered relevant and detailed responses. The survey also asked about satisfaction with the site, gender of the respondent, and relationship to the individual being cared for. Content analysis was used todevelop a coding dictionary, to code responses into information-seeking categories, andto identify overarching themes. Results: Of the respondents (76% of whom were female), 50% indicated they were caring for parents, 17% for themselves only, and 31% for others. Overhalf (57%) reported finding what they were looking for, and 46% stated they were extremely likely to recommend the website. Frequently mentioned information-seeking categoriesincluded "health information," "practical caregiving," and "support." Respondents also requested information related to housing, legal, insurance,and financial issues. Many responses referred to multiple comorbid conditions and complex caregiving situations. Overarching themes included (1) a desire for assistance with a widerange of practical skills and information and (2) help interpreting symptoms and behavior, such as knowing what life impacts to expect over the course of a health condition or treatment.Conclusion: Visitors to a website targeting adults caring for aging parents reportedseeking both general information on caregiving and specific assistance with the complex custodial, medical, emotional, and financial aspects of caregiving. Visitors requested both information to build caregiving skills as well as assistance in interpreting and knowing what to expect from symptoms,health conditions, and changes in behavior and relationships. Many desired communication with and support from other caregivers. Health care providers and eHealth developers should expect that many caregivers of eldersare using the Internet as a resource. Further research and development is needed to fully realize the Internet's potential for education and support of caregivers.
Theodoroff S.M.,3710 Southwest Us Veterans Hospital Road |
Theodoroff S.M.,Oregon Health And Science University |
Lewis M.S.,3710 Southwest Us Veterans Hospital Road |
Lewis M.S.,Oregon Health And Science University |
And 6 more authors.
Epidemiologic Reviews | Year: 2015
Hearing loss and tinnitus are the 2 most prevalent service-connected disabilities among veterans in the United States. Veterans of Operations Enduring Freedom, Iraqi Freedom, and New Dawn have been exposed to multiple hazards associated with these conditions, such as blasts/explosions, ototoxic chemicals, and most notably high levels of noise. We conducted a systematic literature review of evidence on 1) prevalence of, 2) risk and protective factors for, and 3) functional and quality-of-life outcomes of hearing impairment and tinnitus in US Operations Enduring Freedom, Iraqi Freedom, and New Dawn veterans and military personnel. We identified studies published from 2001 through 2013 using PubMed, PsycINFO, REHABDATA, Cochrane Library, pearling, and expert recommendation. Peer-reviewed English language articles describing studies of 30 or more adults were included if they informed one or more key questions. A total of 839 titles/abstracts were reviewed for relevance by investigators trained in critical analysis of literature; 14 studies met inclusion criteria. Of these, 13 studies presented data on prevalence and 4 on risk/protective factors, respectively. There were no included studies reporting on outcomes. Findings fromthis systematic review will help inform clinicians, researchers, and policy makers on future resource and research needs pertaining to hearing impairment and tinnitus in this newest generation of veterans.
Radcliff T.A.,Texas A&M University |
Regan E.,National Jewish Health |
Cowper Ripley D.C.,Research Service 151B |
Journal of Bone and Joint Surgery - Series A | Year: 2012
Background: Intramedullary nails for stabilizing intertrochanteric proximal femoral fractures have been available since the early 1990s. The nails are inserted percutaneously and have theoretical mechanical advantages over plates and screws, but they have not been demonstrated to improve patient outcomes. Still, use of intramedullary nails is becoming more common. The goal of this study was to examine trends in the use and associated outcomes of intramedullary nailing compared with sliding hip screws in Veterans Affairs (VA) hospitals. Methods: Review of the VA Surgical Quality Improvement Program (VASQIP) data identified 5244 male patients in whom an intertrochanteric proximal femoral fracture had been treated in a VA hospital between 1998 and 2005. The overall sample was used to assess trends in device use, thirty-day mortality, thirty-day surgical complications, and one-year mortality. Next, propensity score matching methods were used to compare 1013 patients identified as having been treated with an intramedullary nail with 1013 patients who had a sliding-screw procedure. Multiple logistic regression models for the matched sample were used to calculate odds ratios for mortality and complications according to the choice of internal fracture fixation. Results: Use of intramedullary nails in VA facilities increased from 1998 through 2005 and varied by geographic region. Unadjusted mortality and complication percentages were similar for the two procedures, with approximately 8% of patients dying within thirty days after surgery, 28% dying within one year, and 19% having at least one perioperative complication. While the choice of an intramedullary nail or sliding-screw procedure was related to the geographic region, year of surgery, surgeon characteristics, and several patient characteristics, it was not associated with thirty-day outcomes in either the descriptive or the multiple regression analysis. Conclusions: Intramedullary nail use increased from 1998 through 2005 but did not decrease perioperative mortality or comorbidity compared with standard plate-and-screw devices for patients treated for intertrochanteric proximal femoral fractures in VA facilities. Level of Evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence. Copyright © 2012 by The Journal of Bone and Joint Surgery, Incorporated.